Above: These comics were used in door-to-door holiday fundraising by Boston's Children's Medical Center, in 1949. Link.
Below: "Security is an Eye Patch." This "comic with a problem" was created by Charles Schultz in 1968, and features Peanuts characters Charlie Brown and Sally. A quick glance at the front cover, and you might think they're talking about crypto or keystroke logging, but no: this is a public health info-strip about an ocular affliction known as "lazy eye," produced for the US Department of Health. Link. (Thanks, Ethan!)