Microbes and obesity – Quirks and Quarks radio show

Quirks and Quarks, CBC's national science radio show, aired a great program yesterday on the multfactorial causes of obesity. Of particular interest were the segments on microbial factors. It turns out that obesity can be triggered in mice by changing which microbes live in their gut. The theory is that microbes harvest nutrients from food, and an excess of some microbes leads to superior caloric extraction. That means that depending on your gut's "microbial nation," you might get two or three times as many calories out of your food as your best friend.


I listen to Quirks every weekend and have done since I was a little kid. It's hands-down my favorite science radio show.

Dr. Jeffrey Gordon, from the Washington University School of Medicine in St. Louis, is also looking for factors that contribute to obesity. He's been studying microbes that live in the gut, and has found that the types of bacteria found in the stomach vary between obese and lean mice. Not only that, but by transferring these bacteria into other mice, he can influence whether they'll turn out skinny or fat.

In a similar vein, Dr. Nikhil Dhurandhar is also looking at microbes. But he's studying viruses. He's found a virus that infects chickens, and makes them gain weight. He's tested humans and found that some obese people carry the same virus, suggesting it may be infecting us, too.

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