I spent the weekend watching every youtube clip tagged "Dr. Steve Brule," alone and with friends, on laptops and iphones. This was Dr. Steve Brule Weekend. The character is played by John C. Reilly, and is part of Tim and Eric Awesome Show Great Job on Adult Swim. LMFAO. This one's my favorite. no, this one. (thanks Coop)
Update: Our old pal Jesse Thorn has this.