Jonathan Rosenberg's webcomic Goats (recently collected into a handsome volume called Goats: Infinite Typewriters) makes me feel like I'm on acid.
That's because every goddamned thing that happens it is incredibly weird -- two wise-asses meet God, trick him into turning into a porkchop, eat him, then their various pets get in the act, cybernetically enhancing themselves, communing with pansexual alien Greys with 13 bladders, animating decapitated bikers by riding their neck-stumps and tugging on their spinal cords, defeating the demons of the Mayan underworld, seeing action movies about Good Space Hitler versus Evil Earth Hitler and so on -- it is never just silly. It's always infrasilly, plumbing depths of silliness that skate on the edge of incomprehensible obscenity and weird-for-the-sake-over without ever slipping over.
That's a good trick. Author Jonathan Rosenberg never seems to be trying to hard to be the class clown. This all has the refreshing spontaneous unforced high weirdness of the weirder Monty Python sketches, and it will reset your freakiness thermometer to a higher threshold than you thought possible.