Scenes from an oxytocin party

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54 Responses to “Scenes from an oxytocin party”

  1. EeyoreX says:

    Well, I´d say that any placebo that can be instrumental in instigating an orgy is money well spent! Who cares if it’s the anticipation that produces the effects or vice versa?

    Isn’t this exactly how “Spanish Fly” used to work before the killyoy scientists publicly exorcised all the placeboey goodness away from that drug?

  2. Razzabeth says:

    Another coin on the ‘oxytocin can’t be taken orally’ pile. You can only snort it or inject it.

    I have snorted it, and it is pretty sweet. Makes you feel all warm and fuzzy in your head. Also, your threshold for pain is about doubled. Oxytocin + sex = fun. But, it’s almost unnoticeable if it’s not in combination. Maybe a light, dizzy, relaxed feeling. Certainly nothing to have a party over. Also, that’s the female experience. The male experience is much more mild/subtle.

  3. Anonymous says:

    This is the anonymous poster from #39.

    Re: #47, In the reference you cited about compounds diffusing across the blood brain barrier they are all relatively small molecules with cross-sectional areas under 80 angstroms. Oxytocin is a 9 amino acid peptide… It is significantly larger than this.

    It also makes me wonder why so many people are trying to make small molecule agonists of the oxytocin receptor if the regular peptide(s) have the pharmokinetics and bioavailability they want.

    Sublingual oxytocin administration has definitely not been shown to have an effect on the central nervous system, despite the mentioned ‘quick’ absorption. Your conjecture is, unfortunately, false.

    Intranasal administration of oxytocin, as you have said, does have a central nervous system effect. This is definitely not what is shown in the video of this ‘party’.

  4. J France says:

    Homeopathy = fail.

    By their own definition, homeopathists (or whatever), willingly defy the laws of physics to create their preparations. It’s faith based – do you believe in molecules, or do you believe in energy.

    These people are examining the placebo effect. Which is even effective when you call it a placebo test study.

    “Here this’ll make you feel good, take it”

    Read also: The thread on advertising and Hitler.

  5. Anonymous says:

    This is completely fake. As many people have said, oxytocin won’t cross the blood brain barrier . It is a peptide, a short chain of proteins (big), and needs active transport beyond simple diffusion.

    If anyone is interested in real (peer reviewed, in real journals) studies on the effects of oxytocin that actually makes it into the central nervous system, see below. Sorry about the length of the URLs.

    http://superkuh.ath.cx/users/superkuh/Library/Oxytocin%20Increases%20Trust%20In%20Humans%20nature03701.pdf
    http://superkuh.ath.cx/users/superkuh/Library/Oxytocin%20is%20Associated%20with%20Human%20Trustworthiness%20ZakatalH.pdf
    http://superkuh.ath.cx/users/superkuh/Library/Trust__%20A%20Temporary%20Human%20Attachment%20Facilitated%20by%20Oxytocin.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Oxytocin%20Improves%20Empathy%20in%20Humans%20BiolPsychiatry-Mind-reading06.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Peripheral%20Pulses%20of%20Oxytocin%20Increase%20Partner%20Preferences%20in%20Female,%20but%20Not%20Male,%20Prairie%20Voles.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/The%20Oxytocin%20Receptor%20System__%20Structure,%20Function,%20and%20Regulation___REVIEW2001.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Oxytocin%20Maintains%20as%20Well%20as%20Initiates%20Female%20Sexual%20Behavior__%20Effects%20of%20a%20Highly%20Selective%20Oxytocin%20Antagonist.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Oxytocin%20and%20Vasopressin%20Receptors%20and%20Species-Typical%20Social%20Behaviors.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Gene%20Targeting%20Approaches%20to%20Neuroendocrinology__%20Oxytocin,%20Maternal%20Behavior,%20and%20Affiliation.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Oxytocinergic%20and%20serotonergic%20innervation%20of%20identified%20lumbosacral%20nuclei%20controlling%20erection%20in%20the%20male.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Oxytocin,%20vasopressin,%20and%20social%20recognition%20in%20mammals.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Oxytocin%20in%20the%20human%20–%20regulation%20of%20derivations%20and%20destinations.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Central%20nervous%20system%20actions%20of%20oxytocin%20and%20modulation%20of%20behavior%20in%20humans.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/The%20oxytocin%20receptor.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-Bio%20And%20Chemistry/A%20relationship%20between%20oxytocin%20and%20anxiety%20of%20romantic%20attachment.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/OXYTOCIN%20MAY%20MEDIATE%20THE%20BENEFITS%20OF%20POSITIVE%20SOCIAL%20INTERACTION%20AND%20EMOTIONS.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/OXYTOCIN%20AND%20ADDICTION__%20A%20REVIEW.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Inhibitory%20effect%20of%20oxytocin%20on%20corticotrope%20function%20in%20humans__%20are%20vasopressin%20and%20oxytocin%20ying–yang%20neurohormones.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Neural%20Correlates%20of%20Pair%20Bonding/Evidence%20for%20an%20interaction%20between%20CB1%20cannabinoid%20and%20oxytocin%20receptors%20in%20food%20and%20water%20intake.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/Vasopressin%20and%20oxytocin%20secretion%20in%20response%20to%20the%20consumption%20of%20ecstasy%20in%20a%20clubbing%20env%202006_Wolff_22746_1.pdf
    http://superkuh.ath.cx/users/superkuh/Library/000-BrainDynamics/relationship%20between%20oxytocin%20and%20anxiety%20of%20romantic%20attachment.pdf
    http://superkuh.ath.cx/users/superkuh/Library/Social%20interaction%20deficits%20caused%20by%20chronic%20phencyclidine%20administration%20are%20reversed%20by%20oxytocin.pdf

  6. Darren Garrison says:

    Homeopathy is too real medicine!:

    http://www.youtube.com/watch?v=HMGIbOGu8q0

  7. fnc says:

    “The meaning of these parties seems to be to loosen women up sexually, of course.”

    Heck, that’s the meaning of most things males do.

  8. pointymartin says:

    Yep. Load of tripe. Intranasal oxytocin works….. Pills do not I’m afraid.

    I have been squirting liberal doses of oxytocin up my nose for a couple of years now. Not on a regular basis, but when I feel I could do with social lubricant, I reach for the atomizer. My dad belives it helped him recover from a recent divorce.

    Personally, I feel too much feels similar to busting your beans…

  9. jksk says:

    I got as far into the video as ‘homepathic doctor’. :P

  10. Anonymous says:

    I’m the author of The Chemistry of Connection, a book about oxytocin and bonding based on scientific studies published in real journals.

    First, the idea of an impermeable blood-brain barrier has proven to be false. Many things can, in fact, cross it. See: http://www.springerlink.com/content/9u2n95w30v8mg48n/

    Inhaled oxytocin absolutely affects the brain; many fMRI studies have shown this.

    These people are not swallowing the lozenges, they’re holding them under the tongue. This area provides quick absorption into the blood stream. Because it’s so close to the nose and has similar tissue, I think it is possible that there might be an effect on the brain, but this is conjecture.

    In any case, oxytocin has strong effects as a hormone traveling through the bloodstream, where it certainly goes via sublingual administration: relaxation, calming, reduction of pain — all of which would make someone more open to others, I’d think.

  11. Anonymous says:

    I’m pretty sure the “Liquid Trust” stuff is a scam. I contacted them to determine the potency of the stuff, in their reply they refused to state how much, if any, oxytocin was in their product:

    “Thank you for your interest in Liquid Trust. It is a trade secret what the formula and the specific dose of Oxytocin is in our product similar to coca cola and it’s soda formula.”

    I replied with the not-stunning information that
    Coca-Cola has a very specific and well known amount of caffiene, a regulated drug, in its product and that it is trivial to find this information on the Internet. Surely oxytocin, a prescription-only drug, must also be required to state the quantity of the active ingredient?

    I received no reply. My conclusion: liquid trust contains effectively no oxytocin, and is merely a homeopathic scam.

  12. Anonymous says:

    Not familiar with oxytocin, but the party and the “marketing” make me think MDMA all over again. Legal, love drug, opens up communication in couples, blah blah blah.

  13. vespabelle says:

    I went to an oxytocin party. It was awesome, I got totally high pushing an 8 lb. human out of my vagina!

  14. Takuan says:

    I hear the CIA uses it after bouts of “articulated interrogation” to create a bond with the interrogator that follows the torturers. Better living through chemistry and Cheney.

  15. Anonymous says:

    Haven’t read all the comments..
    but just a quick add
    I have the “Troches” 5IU Oxytocin lozenges
    Doesn’t cross the blood brain barrier
    Totally ineffective

  16. insomma says:

    Why are you specifying ‘sperm’ ejaculation.. as opposed to what?

  17. Boba Fett Diop says:

    I totally read that as “Oxycontin party” and thought those people looked really healthy and well dressed for that sort of thing.

  18. knodi says:

    When I see a phrase like “examined by a licensed homeopathic doctor”, I immediately assume that everything related to this is a giant placebo.

    HOMEOPATHY IS VOODOO.

  19. moniker42 says:

    It is a brave, brave new world.

  20. Teresa Nielsen Hayden says:

    Of course homeopathy is voodoo.

    EeyoreX @24:

    Isn’t this exactly how “Spanish Fly” used to work before the killjoy scientists publicly exorcised all the placeboey goodness away from that drug?

    EeyoreX, the reason scientists put the kibosh on Spanish Fly was because it’s toxic and can be quite dangerous. It’s also useless, but almost all supposed aphrodisiacs are.

  21. buddy66 says:

    Wow. Sounds like WIN all around for a loving couple.

  22. Stu Mark says:

    All day long I’ll be saying “lozenger.” That saddens me, as it reflects poorly on my character. Lozenger.

  23. Anonymous says:

    Problem: oxytocin does not penetrate the blood brain barrier. As such, it will only have effects in the periphery when taken as a drug.

    Sorry kids, no love-drug for you. You’ll either have to stick to ecstasy or wait until a BBB-permeable agonist makes it through the pipeline.

  24. Anonymous says:

    Er, how come the guy she’s talking to is wearing a rubber glove near the end of the video??? :-/

  25. MadMolecule says:

    Oxytocin tablets? The old fashioned distribution method still seems best to me.

  26. Orky says:

    You know what’s funny about this? That the people who want a stronger effect take two of the supposedly homeopathic lozengers…

  27. Anonymous says:

    I call BS on the oxytocin party. Oxytocin is rapdily destroyed in the stomach – it has to be injected, or else sprayed on mucous membranes.

    I won’t even begin to address the issue of the homeopath.

  28. Jerril says:

    #1) Sperm is a pretty trivial (by volume) portion of ejaculate.

  29. Anonymous says:

    #3

    Exactly. Homeopathy = absolute placebo effect.

  30. Anonymous says:

    I’m very interested but are there any lower quality versions of this? I just spent 20 minutes letting it load less than a minute of video.

  31. pinehead says:

    It sounds like a fun drug. Too bad those pills in the video are BS.

    I did find a dealer of “Liquid Trust” online. They offered a regular and a pheromone-enhanced product. An ounce of it would set you back about $80, plus shipping.

    At that price, you could buy enough oxycodone to make an elephant all giggly. And you don’t need a needle & tourniquet to take oxycodone.

  32. wolfiesma says:

    I couldn’t watch past the repeated lozenger references… but, this looks like a very promising hormone replacement therapy. When you wean a child, especially after two years + of solid feed on demand, your oxytocin levels are, naturally, going to plunge. This explains so much.

  33. Anonymous says:

    Bollocks. It’ll get destroyed in the stomach, and even if it didn’t it wouldn’t make this great a difference. What you’re seeing here is a perfect example of placebo effect.

  34. Anonymous says:

    This is bunk. Firstly, the guy giving it out is a “licensed homeopathic doctor”? Homeopathy is complete bunk. Firstly it relies on “like cures like” and secondly the idea that the more dilute the active ingredient is, the more effective it is.

    Secondly, you can’t take Oxytocin orally. From Wikipedia – http://en.wikipedia.org/wiki/Oxytocin

    Oxytocin is destroyed in the gastrointestinal tract, and therefore must be administered by injection or as nasal spray.

    There’s more there about even the IVs of Oxytocin not working all that great because it’s rejected by the blood-brain barrier.

    All you’re seeing in this video is a placebo effect. People think they’re taking a “love drug” and so act appropriately.

  35. eviladrian says:

    #14 Cortana: I’m paying you ten grand, but it’s been potentiated down to a nickel…

  36. cortana says:

    I also am a licensed homeopathic doctor. I went to 2 hours of medical school, making me 4000x as potent as a normal doctor. You must understand, however, this special potency will require assessment of an additional fee. Thank you for your time.

  37. Mazoola says:

    I’ve used injectable oxytocin to induce laying in an egg-bound Fischer’s chameleon. It worked fine, but she didn’t seem to enjoy it as much as the folks in the video.

  38. Sam Freedom says:

    They just discovered that oxytocin is also responsible for intensifying envy and jealousy… didn’t read it all but I’d say it has to do with not only emotional bonding, but characteristics that would protect that bond… hence, envy and jealousy.

  39. Anonymous says:

    “Certified Homeopathic Doctor” is a lovely double oxymoron :-)

    If I may suggest, a homeopathic pill would be a placebo, that’s true. But also – if the pill DOES do something because of a present active ingredient, then it’s not homeopathic, is it?

  40. MarkM says:

    @3/Knodi:
    Exactly my sentiments. Homeopaths are worse than quacks. Quacks resent the fact they’re lumped in with homeopaths.

    Also, uh, she pronounced lozenge as “lozenger”?

  41. Steiny says:

    #17: “lozengers. Lozengers. LOZENGERS.”

    I see a new Steve Ballmer video…

  42. oxymoron69 says:

    I hope these jokers don’t figure out that eating it does nothing and move up to injecting the shit.

    It has some nasty side effects including:

    an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting);

    difficulty urinating
    chest pain or irregular heart beat
    difficulty breathing
    confusion
    sudden weight gain or excessive swelling
    severe headache
    excessive vaginal bleeding
    seizures

    There is also a potentially fatal risk of ODing on this shit once you start injecting.

    I don’t know about you, but dying from massive vaginal hemorrhaging doesn’t sound like a fun party.

    These fucks should invest in some good e or just start smoking weed.

    Goddamn fake hippies.

  43. Anonymous says:

    A few years ago there was a “dumb criminal” story about a pharmacy that had all its oxytocin stolen; presumably the thief thought it was oxycontin. Or maybe he was just ahead of the curve.

  44. Anonymous says:

    this is silly. oxytocin doesn’t cross the blood-brain barrier. it can be taken nasally (as reported in “Oxytocin increases trust in humans”, three spray pumps into each nostril, Kosfeld et. al. 2005 in “Nature”) but it’s nothing but a placebo if you try to eat it.

  45. Anonymous says:

    You know I thought I’d have something interesting to say after watching the videos, but all I got is…

    lozengers. Lozengers. LOZENGERS.

  46. WalterBillington says:

    Homeopathy – oh come on! Don’t be unfair! There’s lots of science backing it up! Look – here –

    http:// … er …
    https:// …. ummm ….
    http://www.wikipedia.org/... ahhh …

    Say! Let’s look at some marketing numbers instead! First, just look into my eyes. Not around my eyes – IN my eyes. That’s right.

  47. ablestmage says:

    I came to the comments specifically to poke fun about the “lozenger” pronunciation but it seems about a dozen people beat me to it. I thought at first she just goofed, but then it happened again. And again.

    From the comments, however, the only mention of homeopathic anything has to do with the consultation, not with the lozenGE necessarily. I’d like to try one of these purported over-the-counter varieties and see what happens, because I do not at all find myself suggestible.

  48. Anonymous says:

    What /is/ interesting, though, is how taste-makers (either manufactured, or spontaneously because of shared interests and locales) actively search out these sorts of things to experiment with them. This was the roots of the LSD and “designer-drug” parties in the past.

    Typically middle class folks getting together and getting sideways looking for those peak experiences.

    An extreme example might be represented in “Phenethylamines I Have Known And Loved: A Chemical Love Story” but there is also a very good history of LSD that finishes up with a chapter on the (then) new designer drugs like Adam and Ecstasy. I’ve obviously eaten way too many mushrooms, because I can’t remember the title of the last one.

  49. dculberson says:

    Cortana, that was awesome.

  50. Anonymous says:

    There is no magic method for having a good time, even if you use science and biology. They mention nipple play in the first sentence. My husband does this for me sometimes. If it weren’t for the effect it has on him, it would do nothing for me. Everyone is different.

    (Hehe. My captcha is “quaalude Inc”. Speaking of placebos…)

  51. kleer001 says:

    Next you’ll be telling me child immunizations give them autism.

  52. Anonymous says:

    “And you don’t need a needle & tourniquet to take oxycodone.”

    Doesn’t hurt, though.

  53. jetfx says:

    @#19

    The book you’re thinking of is “Storming Heaven: LSD and the American Dream” by Jay Stevens. Awesome book.

  54. Anonymous says:

    Related dispute about pitocin use:

    Many suggest giving it to women in labour is a form of scheduling for the convenience of the obstetrician, and can occasionally lead to delivery complications and (perhaps unnecessary) Caesarean.

    The meaning of these parties seems to be to loosen women up sexually, of course.

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