Replacing $100K diagnostic chip fab with Shrinky-Dinks and a laser-printer

CCrawford sez, "Michelle Khine couldn't afford the $100,000 fabrication gear to make micro-fluidic chips needed for chip-based diagnostic tests. She turned to Shrinky-Dinks and found a new way to solve the problem."
To test her idea, she whipped up a channel design in AutoCAD, printed it out on Shrinky Dink material using a laser printer, and stuck the result in a toaster oven. As the plastic shrank, the ink particles on its surface clumped together, forming tiny ridges. That was exactly the effect Khine wanted. When she poured a flexible polymer known as PDMS onto the surface of the cooled Shrinky Dink, the ink ridges created tiny channels in the surface of the polymer as it hardened. She pulled the PDMS away from the Shrinky Dink mold, and voilà: a finished microfluidic device that cost less than a fast-food meal.

Khine began using the chips in her experiments, but she didn't view her toaster-oven hack as a breakthrough right away. "I thought it would be something to hold me over until we got the proper equipment in place," she says. But when she published a short paper about her technique, she was floored by the response she got from scientists all over the world. "I had no idea people were going to be so interested," Khine says.

A children's toy inspires a cheap, easy production method for high-tech diagnostic chips (Thanks, CCrawford!)

(Image: Dave Lauridsen)