Laboratory mice are not the same creatures you'll find living in your wall or a farm field. Instead, they are highly specialized. Whether born of high-tech genetic manipulation or good, old-fashioned selective breeding, each type of mouse—and there are thousands in the catalogs—is designed to test specific types of questions. Use the wrong mouse, and your data will be worthless. Or, at least, your conclusions will be incorrect.
That's what happened recently, when the authors of a 2006 paper in the Journal of Immunology retracted their work after belatedly realizing that it was based on studies done with the wrong mouse. They'd meant to buy a mouse that lacked a specific gene. Instead, thanks to a simple typo, they'd ended up with mice that lacked that gene—and a key chemical receptor in its cells, which changed the outcome of the research.
I've written a little about the strange world of laboratory mice, both here, and in mental_floss. Want more? There's a Wired story by Gary Wolfe that will interest you, as well.
(Via Alexandra Witze)
Scientific American summarized five of Donald Trump’s “major moves many see as hostile toward science.” They are: • Trump’s pick for head of the U.S. Environmental Protection Agency has actively battled its mission “To lead the EPA, Trump appointed Scott Pruitt, the Oklahoma attorney general who has long opposed environmental regulations and has questioned the science […]
Why does The Caterpillar Lab only have 44 subscribers? Caterpillars set to smooth jazz, like these gorgeous stinging rose caterpillars checking each other out, make this New Hampshire nonprofit a hidden gem.
A paper from a group of Kings College London researchers documents an unexpected and welcome side effect from an experimental anti-Alzheimer’s drug called Tideglusib: test subjects experienced a regeneration of dentin, the bony part of teeth that sits between the pulp and the enamel.
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