The biology of itching and the biology of pain are intertwined in interesting ways, writes graduate student and science blogger Aatish Bhatia. Understanding itching can help us better understand how to treat pain. I'd not seen Bhatia's blog before, but I'm really liking his style. He does a great job of breaking down the science in a clear way.
... In the last decade, researchers have learned about receptors in the nerves under our skin that react specifically to itchy substances. When these receptors fire, they send a signal racing up our spinal cord, headed to our brain where it creates an urge to scratch. Scientists now have a basic map of the roads that an itch takes on its way to our brain. And they have even been able to block some of these roads in mice, essentially preventing them from feeling an itch.
...The picture that is emerging is a complex one, where pain and itch signals are distinct yet subtly intertwined. Of the nerve cells under our skin, some are involved only in signalling pain, and they have pain receptors. Others are responsible for signalling different types of itches, and they have both itch and pain receptors. If the same cell has both receptors, how do we distinguish itch from ouch?
... As the biology of itching becomes better understood, the benefits are making their way from the lab to the clinic. The drug morphine is a powerful painkiller, but has a common side effect of itchiness. Women taking opiates to relieve their labour pain often experience a similar side effect. Zhou-Feng Chen and Yan-Gang Sun, authors of the GRPR receptor study, teamed up with colleagues at the newly founded Center for the Study of Itch and managed to tackle this problem. Their results, published in the current issue of the journal Cell, show that the benefits of morphine can be separated from the itch.
Via Greg Laden
Image: llama itch, a Creative Commons Attribution (2.0) image from davedehetre's photostream
To demonstrate the Magnus effect, YouTuber PeterSripol grabbed a couple of KFC buckets and tricked out an RC plane. The resulting trial and error is mostly the latter.
One of the weirdest places in Antarctica is Blood Falls, a five-story cascade of blood-red liquid pouring from Taylor Glacier. Researchers finally traced its source: a saltwater lake millions of years old trapped under the glacier.
Fetal lambs survived for weeks in an experimental artificial womb, and scientists hope that the breakthrough could lead to new treatments for premature babies and perhaps the dreamed-of machine utopia where humans are kept mindlessly writhing in translucent plastic sheaths filled with psuedoamniotic liquid. Physicians at the Children’s Hospital of Philadelphia placed fetal lambs into […]
Bamboo has lots of uses beyond just being panda food. Things like bikes, roads, scaffolding, and musical instruments are made from the fast-growing grass. But unless you are participating in a tropical-themed LARP, you probably wouldn’t want a shirt made from bamboo stalks. So why do bamboo bed sheets make any sense? Because yarn extracted from […]
If you want to work in tech, but don’t have any desire to code web apps to help businesses sell things to other business, you might want to consider a career in cybersecurity. Judging from the apparent complete infiltration of Russian hackers in American cyberspace, it seems fair to speculate that there’s a major shortage of […]
All moms are different. But all moms like getting flowers on Mother’s Day, and that’s a fact (not, however a fact we can document in any fashion.) Instead of getting chewed out for forgetting to call her on the second Sunday of May, you can take care of it ahead of time with Teleflora’s flower […]