The biology of itching and the biology of pain are intertwined in interesting ways, writes graduate student and science blogger Aatish Bhatia. Understanding itching can help us better understand how to treat pain. I'd not seen Bhatia's blog before, but I'm really liking his style. He does a great job of breaking down the science in a clear way.
... In the last decade, researchers have learned about receptors in the nerves under our skin that react specifically to itchy substances. When these receptors fire, they send a signal racing up our spinal cord, headed to our brain where it creates an urge to scratch. Scientists now have a basic map of the roads that an itch takes on its way to our brain. And they have even been able to block some of these roads in mice, essentially preventing them from feeling an itch.
...The picture that is emerging is a complex one, where pain and itch signals are distinct yet subtly intertwined. Of the nerve cells under our skin, some are involved only in signalling pain, and they have pain receptors. Others are responsible for signalling different types of itches, and they have both itch and pain receptors. If the same cell has both receptors, how do we distinguish itch from ouch?
... As the biology of itching becomes better understood, the benefits are making their way from the lab to the clinic. The drug morphine is a powerful painkiller, but has a common side effect of itchiness. Women taking opiates to relieve their labour pain often experience a similar side effect. Zhou-Feng Chen and Yan-Gang Sun, authors of the GRPR receptor study, teamed up with colleagues at the newly founded Center for the Study of Itch and managed to tackle this problem. Their results, published in the current issue of the journal Cell, show that the benefits of morphine can be separated from the itch.
Via Greg Laden
Image: llama itch, a Creative Commons Attribution (2.0) image from davedehetre's photostream
Urine is golden so it must have some link to gold, thought medieval alchemists seeking to devise methods to transmute base metal into gold. Not quite, but they did discover that pee is rich with the miraculous bearer of light, aka phosphorus. (American Chemical Society)
I’ve heard — and repeated — the theory that addiction rates among indigenous people in the Americas was caused by genetics — specifically, that “new world” populations hadn’t gone through the European plague years’ genetic bottleneck that killed everyone who couldn’t survive on alcoholic beverages (these having been boiled during their production and thus less […]
The PocketLab is billed as a “Swiss Army Knife of science.” Launched via Kickstarter, the small device contains numerous sensors to measure acceleration, force, angular velocity, magnetic field, pressure, altitude, and temperature and send that data to smartphones or laptops. According to inventor Clifton Roozeboom, it’s a tool for students and citizen scientists who can’t […]
The Lytro Illum dares to be different, boasting even more robust features than its first generation predecessor and a sleek design reminiscent of professional DSLRs. What’s so cool about it? Most cameras capture the position of light rays, producing a statoc 2D image.
SitePoint Premium is the ultimate e-learning library for web developers, designers, and digital professionals. Famous for their web development books written by industry leaders, they’ve expanded their content library to include in-depth video courses and short, handy screencasts partnering with A Book Apart and UX Mastery. Whatever you want to achieve in your web career, […]
Skip the technical jargon and get right to taking amazing, professional-quality photos with this complete training. The Hollywood Art Institute Photography Course includes 22 modules filled with tutorials on how to profit off of your photography, or simply capture your memories in the manner they deserve.Accredited by the Photography Education Accreditation CouncilDive into this 22 […]