The biology of itching and the biology of pain are intertwined in interesting ways, writes graduate student and science blogger Aatish Bhatia. Understanding itching can help us better understand how to treat pain. I'd not seen Bhatia's blog before, but I'm really liking his style. He does a great job of breaking down the science in a clear way.
... In the last decade, researchers have learned about receptors in the nerves under our skin that react specifically to itchy substances. When these receptors fire, they send a signal racing up our spinal cord, headed to our brain where it creates an urge to scratch. Scientists now have a basic map of the roads that an itch takes on its way to our brain. And they have even been able to block some of these roads in mice, essentially preventing them from feeling an itch.
...The picture that is emerging is a complex one, where pain and itch signals are distinct yet subtly intertwined. Of the nerve cells under our skin, some are involved only in signalling pain, and they have pain receptors. Others are responsible for signalling different types of itches, and they have both itch and pain receptors. If the same cell has both receptors, how do we distinguish itch from ouch?
... As the biology of itching becomes better understood, the benefits are making their way from the lab to the clinic. The drug morphine is a powerful painkiller, but has a common side effect of itchiness. Women taking opiates to relieve their labour pain often experience a similar side effect. Zhou-Feng Chen and Yan-Gang Sun, authors of the GRPR receptor study, teamed up with colleagues at the newly founded Center for the Study of Itch and managed to tackle this problem. Their results, published in the current issue of the journal Cell, show that the benefits of morphine can be separated from the itch.
Via Greg Laden
Image: llama itch, a Creative Commons Attribution (2.0) image from davedehetre's photostream
Apple released this lovely new commercial featuring Carl Sagan reading from his magnificent 1994 book Pale Blue Dot: A Vision of the Human Future in Space, now available as an audiobook. This surprising partnership spurred Adweek to interview my friend Ann Druyan, Sagan’s wife, collaborator, and creative director of the Voyager Golden Record, about being […]
The Action Lab took a maglev gyroscope and placed it inside a sealed chamber to see what happens to a levitating gyroscope in a vacuum. A lot of people took issue with the experiment’s setup and explanation, but it’s interesting nonetheless. He responded to those concerns: Hi everyone! I see a lot of comments that […]
Shocking footage, taken from a nearby aircraft, shows a jetliner spraying its appalling chemical payload into our skies. Traffic 12 o'clock pic.twitter.com/g5QjlQ5v8z— Airplane Pictures ✈ (@iLove_Aviation) June 19, 2017
Although flagship smartphones are unlikely to adopt heavy-duty outer casing anytime soon, you can always prepare your device for the outdoors with a beefy case and and an external battery like this Nomad Tile Trackable PowerPack, available in the Boing Boing Store for $119.95.The Nomad Tile can fully recharge an iPhone 7 over three times […]
Even though credit cards now feature an EMV chip for securing transactions, they still have to include the magnetic strip for compatibility with older point of sale systems. Because of this, there’s no way for the chip’s new security capabilities to protect against card skimmers in the wild.How do you protect yourself from legacy-technology-induced fraud? […]
As the old saying goes, “You should sit in meditation for 30 minutes every day. Unless you are too busy, in which case you should meditate for an hour.” Since most of us have an endless list of things to do and people to see, carving out quiet time can feel impossible, especially when most […]