The biology of itching and the biology of pain are intertwined in interesting ways, writes graduate student and science blogger Aatish Bhatia. Understanding itching can help us better understand how to treat pain. I'd not seen Bhatia's blog before, but I'm really liking his style. He does a great job of breaking down the science in a clear way.
... In the last decade, researchers have learned about receptors in the nerves under our skin that react specifically to itchy substances. When these receptors fire, they send a signal racing up our spinal cord, headed to our brain where it creates an urge to scratch. Scientists now have a basic map of the roads that an itch takes on its way to our brain. And they have even been able to block some of these roads in mice, essentially preventing them from feeling an itch.
...The picture that is emerging is a complex one, where pain and itch signals are distinct yet subtly intertwined. Of the nerve cells under our skin, some are involved only in signalling pain, and they have pain receptors. Others are responsible for signalling different types of itches, and they have both itch and pain receptors. If the same cell has both receptors, how do we distinguish itch from ouch?
... As the biology of itching becomes better understood, the benefits are making their way from the lab to the clinic. The drug morphine is a powerful painkiller, but has a common side effect of itchiness. Women taking opiates to relieve their labour pain often experience a similar side effect. Zhou-Feng Chen and Yan-Gang Sun, authors of the GRPR receptor study, teamed up with colleagues at the newly founded Center for the Study of Itch and managed to tackle this problem. Their results, published in the current issue of the journal Cell, show that the benefits of morphine can be separated from the itch.
Via Greg Laden
Image: llama itch, a Creative Commons Attribution (2.0) image from davedehetre's photostream
James Delingpole is an invective-hurling anti-climate science columnist who has candidly admitted that he doesn’t bother to read scientific papers, calling himself a “an interpreter of interpretations.”
Kratom (previously) is a widely used herb that has been very effective in treating opioid withdrawal and other chronic, hard-to-treat conditions — it also became very controversial this year because the DEA decided, without evidence, to class it as a dangerous drug, and then changed its mind (unprecedented!) after a mass-scale petition that included interventions […]
In a curious study, researchers at the University of California, Los Angeles showed that transcranial magnetic stimulation (TMS) — altering brain activity by zapping specific regions with magnetic pulses — can apparently increase people’s libido, at least briefly. Neuroscientist Nicole Prause and her colleagues targeted the left dorsolateral prefrontal cortex (at the left temple), a […]
Loot Crate is a totally different kind of subscription service that mails subscribers monthly boxes filled with curated geek, pop culture, and gamer paraphernalia. Its cult following awaits a box every month filled with everything from bobble heads to T-shirts to special edition collectibles. But nothing gets Loot Crate fans as excited as the limited […]
The ARMOR-X Mini Flexible Phone Tripod is a smartphone tripod that is designed with flexible legs to rest on virtually any type of surface. Other tripods have proved useless unless I conveniently have a flat surface in front of me, which is why this particular tripod was appealing enough to try out. The ARMOR-X is compact and easy […]
You don’t need to get an advanced degree and take out massive loans to become a coder. This bundle of 10 courses was designed to teach anyone to code at home for less than it costs to go out for dinner. I was particularly impressed with this new 2017 bundle because it includes courses on […]