We've talked here before about the importance of the protein CCR5 in HIV/AIDS treatment research. CCR5 is a protein on the surface of immune cells. Some people have a genetic mutation, called Delta-32, which alters how that protein works, how often it appears, or changes its structure. People with the mutation have immunity to some strains of HIV, the virus that causes AIDS.
CCR5 is the key to the Berlin Patient—Timothy Ray Brown—who, until recently, was the only person to ever be cured of AIDS. Brown received bone marrow transplants from people who had the Delta-32 mutation. His body has been HIV-free for five years. And, last week, researchers announced that two other people successfully received the same treatment.
But here's the thing, until today, I didn't totally understand how the connection between CCR5, Delta-32, and HIV worked. There's a story (and some great digital illustrations) on NPR's Shots blog that makes the situation much more clear. HIV, apparently, have little spikes all over its surface. These spikes are how the virus injects itself into cells.
When it bumps into a T cell, a finger-like projection on the cell's surface, called CCR5, pushes down on the spike. This interaction pops open the HIV and releases the infectious genes into the cell. A gene therapy could protect T cells by inactivating the CCR5 gene.
Great "A-ha!" moment for me. Read the rest of the story and look at the illustrations. It'll make some thing make a lot more sense.
Read the rest at NPR's Shots blog
If AIDS Has Been Cured, Why is the Victory Party So Small?
AIDS Research Done by 17-Year-Olds
Frog tongue mechanism has been well-documented, but only recently have scientists started looking at the remarkable combo of tongue softness and frog spit’s chemical makeup.
Elenco’s Night ‘n Day Mechanical Globe uses a system of translucent, exposed gears to rotate an internally illuminated globe that displays the seasonally adjusted, real-time night/day terminator as it spins.
KSU plant biochemical geneticist Raj Nagarajan describes the properties of Thaumatin, Monellin and Brazzein, all found in west African plants that are generally considered safe for consumption; each is a protein, and they are, respectively, 1,000x, 2000x, and 3000x sweeter than sugar.
Not all hackers are malicious information thieves—white-hat ethical hackers work with technology companies to ensure the security of their computer systems and user data. With all of today’s high-profile data breaches, ethical hackers are in considerable demand. To learn these critical skills and break into the high-paying cyber security field, try taking the courses in this […]
Making people aware of goods and services in the digital age requires an array of new strategies from social media and email to number-crunching tools like Google Analytics. To get a handle on the techniques used to capture attention and convert traffic into dollars in a crowded online environment, the Full-Stack Marketer Bundle offers 22 hours of training to get […]
Having a luxurious bed isn’t just a fairy tale from a catalog; it is a real, affordable possibility with offerings like this Olive+Owen bedroom set. If you’re thinking of doing some “spring cleaning”, this bed set is an easy way to completely upgrade your room in one purchase.This 20-piece collection has all of the expected slumberland elements, […]