We've talked here before about the importance of the protein CCR5 in HIV/AIDS treatment research. CCR5 is a protein on the surface of immune cells. Some people have a genetic mutation, called Delta-32, which alters how that protein works, how often it appears, or changes its structure. People with the mutation have immunity to some strains of HIV, the virus that causes AIDS.
CCR5 is the key to the Berlin Patient—Timothy Ray Brown—who, until recently, was the only person to ever be cured of AIDS. Brown received bone marrow transplants from people who had the Delta-32 mutation. His body has been HIV-free for five years. And, last week, researchers announced that two other people successfully received the same treatment.
But here's the thing, until today, I didn't totally understand how the connection between CCR5, Delta-32, and HIV worked. There's a story (and some great digital illustrations) on NPR's Shots blog that makes the situation much more clear. HIV, apparently, have little spikes all over its surface. These spikes are how the virus injects itself into cells.
When it bumps into a T cell, a finger-like projection on the cell's surface, called CCR5, pushes down on the spike. This interaction pops open the HIV and releases the infectious genes into the cell. A gene therapy could protect T cells by inactivating the CCR5 gene.
Great "A-ha!" moment for me. Read the rest of the story and look at the illustrations. It'll make some thing make a lot more sense.
Read the rest at NPR's Shots blog
If AIDS Has Been Cured, Why is the Victory Party So Small?
AIDS Research Done by 17-Year-Olds
Can you “hear” motion or light flashes? If so, according to new research from City University London, you may be experiencing a not-so-rare form of synaesthesia. Synesthesia is the fascinating neurological phenomenon whereby stimulation of one sense involuntarily triggers another sensory pathway. For example, a synesthete might taste sounds or hear colors. (In this study, […]
Scientists declared the ruby seadragon a new species in 2015, but that was based on dead specimens in a museum. Now though, Scripps Institution of Oceanography biologist Greg Rouse who led the team that originally discovered the species, managed to find two of the wonderful fish swimming around the Recherche Archipelago, off the south coast […]
Scientific American summarized five of Donald Trump’s “major moves many see as hostile toward science.” They are: • Trump’s pick for head of the U.S. Environmental Protection Agency has actively battled its mission “To lead the EPA, Trump appointed Scott Pruitt, the Oklahoma attorney general who has long opposed environmental regulations and has questioned the science […]
Using my iPhone while it’s charging is always a hassle. With tucked-away outlets and the meager length of included lightning cables, comfortable scrolling while plugged in is annoying. These 10-Ft MFi-Certified Lightning Cables are super convenient and probably the best iPhone accessory purchase I’ve made.At over three times the length of normal cables, these reach anywhere you […]
With countless applications for modern life, artificial intelligence (AI) is one of the most in-demand fields of study in tech. Beyond modelling human decision making processes and learning abilities, AI can be used to analyze massive volumes of data and create complex interactive systems.This Machine Learning & AI for Business Bundle made mastering these concepts possible for […]
Computer hacking isn’t just something happening to the DNC. Major software companies need white-hat hackers to ensure the security of their products and users, and I came across a Computer Hacker Professional Certification Package that conveniently teaches those advanced IT techniques online.This course package will prepare you for various computer security certification exams with over 60 hours […]