Why one mutation can protect people from HIV

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16 Responses to “Why one mutation can protect people from HIV”

  1. RKTR ♫soundcloud.com/rktr says:

     Pretty cool to see that years of research are finally paying off!

  2. Gilbert Wham says:

    JD Shapely…

  3. BunnyShank says:

    I wonder if the Delta-32 mutation is the same mutation that makes people immune to bubonic plague, and if the cell process is the same as with HIV.

  4. NelC says:

    Surely, springing open the HIV cell is only half the story? You also have to open the T-cell, so that the retroviral genes get into it?

  5. he’s merely pretty lucky. if the virus inside him wasn’t R5-tropic, the effect wouldn’t have made a difference.

  6. danegeld says:

    That rendering looks like a plushy-aids virus. Can we get the knitted?

  7. luisella says:

    Well the cure for cancer has been discovered in 2006. It’s a dirty chip drug used for diabetes, but no Big Pharma would support the trials because its patent expired in 2002.

    http://edition.cnn.com/2012/04/05/health/diabetes-drug-fights-cancer/index.html

  8. billstewart says:

    Bone-marrow transplants are pretty radical treatment.  Now that we know how this works, does that mean it’d be possible to make a CCR-5 blocker drug that would help people with normal T-cells?

  9. Patrick J. Szucs Jr. says:

    The two new patients did not receive the Delta-32 mutation according to an NPR article.

    “Not necessarily, the Boston researchers say. The donor cells their patients got did notlack the receptor. So what’s happening with them must be different from the Berlin patient.”  Richard knox.

  10. Now how can people get tested for the mutation if they want to become bone marrow donors?

  11. Flarn Buckholter says:

    We’ve suspected  this CCR/HIV connection for years, but blocking a chemokine receptor (CCR5 is C-C motif chemokine receptor) affects an immune cell’s ability to respond to signals.  APCs might not migrate properly or phagocytose properly in response to infection.

    You’d beat HIV and fall victim to a bacterium…Global blocking of a chemokine receptor is not good.

    • gehringer says:

       Hmm…any known way to temporarily turn the receptor off, wait for the HIV to flush out of the system, and then let the receptor turn back on?

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