Stem cell madness

Last week, Shinya Yamanaka won a Nobel Prize for figuring out how to make adult stem cells revert to an embryonic (and much more medically useful) state. Within days, another scientist unconnected to Yamanaka, claimed to have produced such cells from human heart tissue and injected them back into human patients in a clinical trial. What's more, the researcher, Hisashi Moriguchi, claimed that a measure of his patients' heart function improved by 41.5% after the transplant.

It's hard to say which is crazier: The claims themselves, or the speed with which Moriguchi's story has completely fallen apart. Evidence suggests that these kind of re-programmed adult stem cells might be more likely to turn cancerous. Because of that, one of the first questions people asked was about the ethics committee that approved the research. Moriguchi said he worked for Harvard and that Harvard had signed off on his clinical trial.

And that's where things got nuts. Because Harvard had never heard of this study. And Moriguchi does not work there, anyway. In fact, this might not even be his field — the only professional affiliation that New Scientist could track down for him was as a visiting researcher in cosmetic surgery at The University of Tokyo. Also: The transplants may or may not have actually happened and Moriguchi might be plagiarizing images from other scientists. The worst part about this (from my perspective as a journalist) is that it was stem cell researchers who had to call out the fraud, after a major Japanese newspaper swallowed the story hook, line, and sinker.

New Scientist has a nice summary of this mess

You can follow the story much more in-depth at IPSCell.com, the blog of UC Davis stem cell researcher Paul Knoepfler.

Check out this post of Knoepfler's — written the day before the Moriguchi madness began — for more information on the risks of reprogrammed adult stem cells, the ongoing safety research, and proposed time-tables for when we will likely try these things out on humans for real.

• [Paul Renault]

  “41.5%” improvement?  No, not 41.4%, nor 41.6%… 

  It sounds like the ‘clinical studies’ for skin care products…

• [Jerril]

  It sounds like someone with a bit of a problem with compulsive lying really spiralled out of control. I “understand” the motivations for academic fraud, but it seems most of the fraud is vaguely plausible (ie: person is actually a researcher, fraud is related to their field of research). I am amazed that someone would think they’d get away with fraud of this magnitude. I actually have difficulty calling it “fraud” and not “a bald-faced lie”.

  Wackadoo tag, very appropriate.

  • [EH]

    Another example of crazies existing at all strata of society.

• [autark]

  Somebody should publish a method for returning adult journalists to their embryonic state and reprogramming them to publish whatever story line you inject them with.

• [Matthew Petty]

  Moriguchi used protomatter in the Genesis Matrix.