The tl;dr: If a medical study seems too good to be true, it probably is. Eryn Brown in the Los Angeles Times writes about
a statistical analysis of nearly 230,000 trials compiled from a variety of disciplines, published today in the Journal of the American Medical Association. The analysis by Stanford's Dr. John Ioannidis and a team of fellow researchers looked at study results claiming a "very large effect," and found that those claims seldom ended up being true when other research teams tried to repeat the same results.
One such example: the cancer drug Avastin. Clinical trials suggested the drug might double the time breast cancer patients could live with their disease without getting worse. But follow-up studies found no improvements in progression-free survival, overall survival or patients' quality of life. As a result, the U.S. Food and Drug Administration in 2011 withdrew its approval to use the drug to treat breast cancer, though it is still approved to treat several other types of cancer.
With early glowing reports, Ioannidis said, "one should be cautious and wait for a better trial."
Read the full LAT article. Here's the JAMA paper, but you have to be a paid subscriber to read it.
To demonstrate the Magnus effect, YouTuber PeterSripol grabbed a couple of KFC buckets and tricked out an RC plane. The resulting trial and error is mostly the latter.
One of the weirdest places in Antarctica is Blood Falls, a five-story cascade of blood-red liquid pouring from Taylor Glacier. Researchers finally traced its source: a saltwater lake millions of years old trapped under the glacier.
Fetal lambs survived for weeks in an experimental artificial womb, and scientists hope that the breakthrough could lead to new treatments for premature babies and perhaps the dreamed-of machine utopia where humans are kept mindlessly writhing in translucent plastic sheaths filled with psuedoamniotic liquid. Physicians at the Children’s Hospital of Philadelphia placed fetal lambs into […]
All moms are different. But all moms like getting flowers on Mother’s Day, and that’s a fact (not, however a fact we can document in any fashion.) Instead of getting chewed out for forgetting to call her on the second Sunday of May, you can take care of it ahead of time with Teleflora’s flower […]
Yeah, Bluetooth audio is pretty common these days, so why should you care about these earbuds? Look how happy that woman up above looks. She’s got FRESHeBUDS in. Boom. There’s your reason. She’s also at the beach and it appears to be a very nice day.But for the sake of promotion, wireless earbuds are fast becoming the […]
“Gets stuff done,” is a good way to be described by anybody. Especially by coworkers or bosses. Because whether you’re in finance or a children’s librarian, stuff needs to get done. But how do you make sure stuff gets done? You definitely can’t do all the stuff yourself, unless your company/organization/government office consists entirely of you. And […]