The tl;dr: If a medical study seems too good to be true, it probably is. Eryn Brown in the Los Angeles Times writes about
a statistical analysis of nearly 230,000 trials compiled from a variety of disciplines, published today in the Journal of the American Medical Association. The analysis by Stanford's Dr. John Ioannidis and a team of fellow researchers looked at study results claiming a "very large effect," and found that those claims seldom ended up being true when other research teams tried to repeat the same results.
One such example: the cancer drug Avastin. Clinical trials suggested the drug might double the time breast cancer patients could live with their disease without getting worse. But follow-up studies found no improvements in progression-free survival, overall survival or patients' quality of life. As a result, the U.S. Food and Drug Administration in 2011 withdrew its approval to use the drug to treat breast cancer, though it is still approved to treat several other types of cancer.
With early glowing reports, Ioannidis said, "one should be cautious and wait for a better trial."
Read the full LAT article. Here's the JAMA paper, but you have to be a paid subscriber to read it.
After years of speculation and wrangling over his remains, Kennewick Man turns out to be closely related to contemporary, local Native Americans after all. Discovered near Kennewick, Wash., in 1996, the skeleton ended up in a tug of war between tribes in the pacific northwest who wanted to bury the remains, and scientists who wanted […]
Our solar system is awesome.
The European Organization for Nuclear Research, or CERN, has been releasing portions of its research to the public for years. This week’s massive 300 terabyte dump of Large Hadron Collider (LHC) data is the biggest yet by a long shot — and it’s all out there, open source, free for the exploration.
You never know when new projects, ideas or opportunities can drop into your lap at a moment’s notice. That may require you to learn a new programming language like Python. Or maybe you need a primer on 3D game development. Or you might realize you could use a serious brush-up on iOS mobile creation.Point is, […]
Isn’t it about time to stretch what your Mac can do? I mean, you’ve got plenty of great programs now…but don’t you think you could use some new tools to get your creative, analytical and organizational juices really flowing? It’s spring, so we cleaned up a whole bunch of super-cool apps lying around and packaged […]
In the world of app development, there’s no greater arena to find success than with Android users. About 80% of the smartphones in use today worldwide operate on the Android operating system, so if you build a great app that Android users love, you’re an international rock star. You’ll be able to make sure your […]