I finally got around to reading Carl Zimmer's highly-recommended National Geographic
article about antibiotics and their effect on our microbiome, the "100 trillion microbes that live in our healthy bodies."
Scientists are only now beginning to get answers to those questions. In a paper just published online in the journal Gut, Andres Moya of the University of Valencia and his colleagues took an unprecedented look at a microbiome weathering a storm of antibiotics. The microbiome belonged to a 68-year-old man who had developed an infection in his pacemaker. A two-week course of antbiotics cleared it up nicely. Over the course of his treatment, Moya and his colleagues collected stool samples from the man every few days, and then six weeks afterwards. They identified the species in the stool, as well as the genes that the bacteria switched on and off.
What’s most striking about Moya’s study is how the entire microbiome responded to the antibiotics as if it was under a biochemical mortar attack. The bacteria started producing defenses to keep the deadly molecules from getting inside them. To get rid of the drugs that did get inside them, they produced pumps to blast them back out. Meanwhile, the entire microbiome powered down its metabolism. This is probably a good strategy for enduring antibiotics, which typically attack the molecules that bacteria use to grow. As the bacteria shut down, they had a direct effect on their host: they stopped making vitamins and carrying out other metabolic tasks.
When You Swallow A Grenade
25 NHS trusts and multiple doctors’ practices in England and Scotland (but so far, not Northern Ireland or Wales) report that they have had to effectively shut down due to a massive Wcry ransomware infection that has stolen whole swathes of the English healthcare system in one go. The infection appears to exploit a bug […]
Trumpcare was dead on arrival (again) until Rep Tom MacArthur [R-NJ; Twitter: @RepTomMacArthur; DC: (202) 225-4765; Burlington County: (856) 267-5182; Ocean County: (732) 569-6495] introduced an amendment that allowed insurers to refuse to cover people with “pre-existing conditions” including surviving domestic violence and/or rape, living with PTSD, being born with a congenital defect, and so […]
The War on Drugs hasn’t just destroyed cities and families by imprisoning millions while enriching organized crime syndicates: it’s also denied millions more access to promising therapies for crippling psychological and physiological ailments.
If you are camping during rainy season, or just want a TSA-approved lighter, these plasma torches make perfect travel companions. These gas-free lighters create a small plasma beam that’s safer than butane to use and more environmentally friendly. It creates a super-hot, splashproof flame so you can get a campfire going, or have a smoke […]
If you don’t want to get stuck footing the bill for a hit and run, this dashboard-mounted camera offers up to 2K resolution to make sure you always have a reliable witness, and it’s available in the Boing Boing Store for 30% off it’s usual price.The PapaGo mounts unobtrusively to your windshield to see everything […]
While some people still maintain that everything in Apple’s walled garden “just works” and is immune to the rampant malware of the Windows world, the reality is different. The Mac’s growing market share has made it a much more viable target for malicious actors, and its built-in tools aren’t always enough to fix things. Drive […]