In 1961, Mel Blanc, the voice of Bugs Bunny, Porky Pig, Barney Rubble, and literally a thousand other cartoon characters (see vide above), was in a terrible car crash that put him in a coma. Nothing could rouse him until his surgeon addressed him as Bugs Bunny. Of course, Blanc's response was: "What's up, Doc?" Here's a 2012 short episode of Radiolab where they interview the surgeon, a neuroscientist, and Mel Blanc's son, Noel.
"What's Up, Doc?" (Radiolab)