Could this simple sea creature hold the key to treating Parkinson's?

A comb jelly, via Whitney laboratory for Marine Biosciences, University of Florida.  REUTERS/Whitney laboratory for Marine Biosciences, University of Florida.

A comb jelly (University of Florida).

A scientist in Florida who studies simple sea animals known as comb jellies says he has discovered a path to a new form of brain development that may one day lead to treatments for Parkinson's, Alzheimer's and other neurodegenerative diseases.

Comb jellies, or ctenophores, look like tiny disco balls and propel themselves around oceans using specialized hairs, lapping up small prey with their sticky tentacles. “They are aliens who’ve come to Earth,” says Leonid Moroz, a neuroscientist at the University of Florida in St Augustine.

The genome of the Pacific sea gooseberry (Pleurobrachia bachei)...adds to the mystery of ctenophores. The sequence omits whole classes of genes found in all other animals, including genes normally involved in immunity, develop­ment and neural function. For that reason, the researchers contend that ctenophores evolved a nervous system independently.

Leonid L. Moroz/Mathew Citarella

Leonid L. Moroz/Mathew Citarella

His findings are published in this week's edition of the journal Nature.

More at Reuters:

Traditional scientific reasoning has held that simple nerve nets evolved all the way up to a human level of complexity along a single path. But it now appears that comb jellies took a different route, using neurochemical language that does not exist in other animals.

"All other animals have the same chemical language and these guys have completely different language. It's not only different grammar. It's a different alphabet," Moroz said.

You can listen to a Nature podcast on the findings here.

Notable Replies

  1. JonS says:

    Betteridge's law?

  2. Ok, the Parkinson's thing is kind of made up still; I imagine it's mostly because of how little concern there often is over pure research. The actual topic is an interesting one, though, at least if you care about comb jellies or animal origins.

    The articles don't really mention it, but even though their lineage split from the other animals some time around the origin of complex tissues, the modern comb jellies are all from one relatively recent group. So they're where to look for insights into the origin of cell types, but beside being hard to place, it's particularly hard to tell which features might be ancient and which are new.

    In light of this, finding that something as fundamental-seeming as nerves might work very differently or even be the result of convergence could say a lot about not just animal relationships, but how they developed. That's the real story for me.

  3. ...scientists also report finally deciphering the comb jellys' frantic gesticulations as signifying: "Me no got key! Me no got key! Harvest sea cucumber over there, very tasty!"

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