In Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis [PDF], a paper in Nature's Journal of Investigative Dermatology, Yale researchers Brittany G Craiglow and Brett A. King document an extremely successful trial in treating total baldness due to alopecia with the rheumatoid arthritis drug tofacitinib citrate. The 25 year old patient, who had both plaque psoriasis and alopecia, grew a full head of hair, as well as eyelashes, eyebrows and armpit hair, and reported no undesirable side effects.
Tofacitinib appears to spur hair regrowth in a patient with alopecia universalis by turning off the immune system attack on hair follicles that is prompted by the disease, King said.
The drug helps in some, but not all, cases of psoriasis, and was mildly effective in this patient’s case, the authors said.
King has submitted a proposal for a clinical trial involving a cream form of tofacitinib as a treatment for alopecia areata.
He cited work by Columbia University scientist Angela Christiano as the reason he decided to try tofacitinib as a therapy in this patient with both alopecia universalis and psoriasis. She has shown thattofacitinib and a related medicine reverse alopecia areata in mice. King called her work exemplary and a clear example of how society’s investment in science research leads to improvement in human life.
“This case highlights the interplay between advances in science and the treatment of disease,” he said, “and it provides a compelling example of the ways in which an increasingly complex understanding of medicine, combined with ingenuity in treatment, benefits patients.”
In hairless man, arthritis drug spurs hair growth — lots of it
[Eric Gershon/Yale News]
Scientists discovered this new species of “glass frog” in Ecuador’s Amazon lowlands. Hyalinobatrachium yaku’s belly is so transparent that you can clearly see its kidneys, bladder, and beating heart. From Science News: Yaku means “water” in Kichwa, a language spoken in Ecuador and parts of Peru where H. yaku may also live. Glass frogs, like […]
Jennifer Raff — a bioanthropologist and geneticist who researches and teaches at U Kansas and U Texas — provides some excellent advice and context on how to read a scientific paper, from figuring out which papers and journals are worthy of your attention to understanding the paper in its wider context in the relevant field.
Apple released this lovely new commercial featuring Carl Sagan reading from his magnificent 1994 book Pale Blue Dot: A Vision of the Human Future in Space, now available as an audiobook. This surprising partnership spurred Adweek to interview my friend Ann Druyan, Sagan’s wife, collaborator, and creative director of the Voyager Golden Record, about being […]
Despite the upfront cost, electric toothbrushes are much better at removing plaque than those freebies from the dentist’s office. For those who struggle to fill the American Dental Association’s recommended two minutes of brushing time, or anyone with limited dexterity, a sonic toothbrush can give your oral care routine a boost.To keep your chops healthy […]
Learning a new language will give your resume an upgrade, sure, but it will also provide a huge cognitive boost for mental tasks outside of translation and conversation. Bilingual brains have been shown to be better at handling multiple concurrent tasks, and gaining fluency in a new tongue is an amazing way to improve memory, […]
If you struggle to get a good night’s rest, consider replacing your pillows before dropping hundreds on a new mattress. You can give your tired neck a break with a 2-pack of memory foam pillows, available now in the Boing Boing Store.Each of these pillows is stuffed with cooling polyurethane foam that molds to your […]