A large-scale, rigorous study published in the Lancet found that the go-to, front-line treatment for back pain was no better than a placebo.
We did a multicentre, double-dummy, randomised, placebo controlled trial across 235 primary care centres in Sydney, Australia, from Nov 11, 2009, to March 5, 2013. We randomly allocated patients with acute low-back pain in a 1:1:1 ratio to receive up to 4 weeks of regular doses of paracetamol (three times per day; equivalent to 3990 mg paracetamol per day), as-needed doses of paracetamol (taken when needed for pain relief; maximum 4000 mg paracetamol per day), or placebo. Randomisation was done according to a centralised randomisation schedule prepared by a researcher who was not involved in patient recruitment or data collection. Patients and staff at all sites were masked to treatment allocation. All participants received best-evidence advice and were followed up for 3 months. The primary outcome was time until recovery from low-back pain, with recovery defined as a pain score of 0 or 1 (on a 0—10 pain scale) sustained for 7 consecutive days. All data were analysed by intention to treat. This study is registered with the Australian and New Zealand Clinical Trial Registry, number ACTN 12609000966291.
Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial [Dr Christopher M Williams PhD, Prof Christopher G Maher PhD, Prof Jane Latimer, Prof Andrew J McLachlan PhD, Mark J Hancock PhD c, Prof Richard O Day MD, Chung-Wei Christine Lin PhD/The Lancet]
(Image: Hydrocodone, Guian Bolisay, CC-BY-SA)
Princeton University psych prof Susan Fiske published an open letter denouncing the practice of using social media to call out statistical errors in psychology research, describing the people who do this as “terrorists” and arguing that this was toxic because of the structure of social science scholarship, having an outsized effect on careers.
Blue writes, “Peter Watts has be stricken with debilitating pain, loss of range of motion and motor control. Watts’ doctors remain baffled despite a battery of tests, and Watts has reached out to his fans to ask for their theories and ideas as to what might be causing his illness.”
Today, I’ve launched a very special Kickstarter with two friends, Timothy Daly and Lawrence Azerrad. A year in the making (and many more years on our minds), the Voyager Golden Record: 40th Anniversary Edition is the first vinyl release of the stunning golden phonograph record launched by NASA in 1977 aboard the Voyager spacecraft, one […]
If you own a dog, you’ve most likely heard of BarkBox – the monthly subscription box for dogs. What started as a simple idea to try out the subscription model on pet owners has since developed a cult following of dog lovers. If you haven’t given it a try yet, this one month free deal is the […]
With the iPhone headphone jack having gone by the wayside, we’re excited about the addition of the FRANKLIN Bluetooth Headphones in our store. These headphones are foldable so they’re easy to carry around, but most importantly, they pack impressive sound. Our biggest struggle with Bluetooth headphones is the worry of them dying at the worst moment. This pair lasts an impressive 8-10 […]
Evan Kimbrell, founder of the digital agency Sprintkick, recently released a series of online courses that feature some of the best advice we’ve come across. These courses are well worth your time, and will save you from making many typical mistakes down the line if you ever want to start your own business.With this Business […]