A large-scale, rigorous study published in the Lancet found that the go-to, front-line treatment for back pain was no better than a placebo.
We did a multicentre, double-dummy, randomised, placebo controlled trial across 235 primary care centres in Sydney, Australia, from Nov 11, 2009, to March 5, 2013. We randomly allocated patients with acute low-back pain in a 1:1:1 ratio to receive up to 4 weeks of regular doses of paracetamol (three times per day; equivalent to 3990 mg paracetamol per day), as-needed doses of paracetamol (taken when needed for pain relief; maximum 4000 mg paracetamol per day), or placebo. Randomisation was done according to a centralised randomisation schedule prepared by a researcher who was not involved in patient recruitment or data collection. Patients and staff at all sites were masked to treatment allocation. All participants received best-evidence advice and were followed up for 3 months. The primary outcome was time until recovery from low-back pain, with recovery defined as a pain score of 0 or 1 (on a 0—10 pain scale) sustained for 7 consecutive days. All data were analysed by intention to treat. This study is registered with the Australian and New Zealand Clinical Trial Registry, number ACTN 12609000966291.
Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial [Dr Christopher M Williams PhD, Prof Christopher G Maher PhD, Prof Jane Latimer, Prof Andrew J McLachlan PhD, Mark J Hancock PhD c, Prof Richard O Day MD, Chung-Wei Christine Lin PhD/The Lancet]
(Image: Hydrocodone, Guian Bolisay, CC-BY-SA)
Frog tongue mechanism has been well-documented, but only recently have scientists started looking at the remarkable combo of tongue softness and frog spit’s chemical makeup.
Elenco’s Night ‘n Day Mechanical Globe uses a system of translucent, exposed gears to rotate an internally illuminated globe that displays the seasonally adjusted, real-time night/day terminator as it spins.
KSU plant biochemical geneticist Raj Nagarajan describes the properties of Thaumatin, Monellin and Brazzein, all found in west African plants that are generally considered safe for consumption; each is a protein, and they are, respectively, 1,000x, 2000x, and 3000x sweeter than sugar.
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Although there will never be a consensus about the best way to make coffee, any coffee connoisseur will agree that controlling the grind of your beans and balancing water temperature are the keys to a tasty cup. Since your plastic coffee pot doesn’t really allow for that kind of customization, going back to the French […]
Not all hackers are malicious information thieves—white-hat ethical hackers work with technology companies to ensure the security of their computer systems and user data. With all of today’s high-profile data breaches, ethical hackers are in considerable demand. To learn these critical skills and break into the high-paying cyber security field, try taking the courses in this […]