Boldly going where nobody's gone before. In a lot of ways, that idea kind of defines our whole species. We travel. We're curious. We poke our noses around the planet to find new places to live. We're compelled to explore places few people would ever actually want to live. We push ourselves into space.
This behavior isn't totally unique. But it is remarkable. So we have to ask, is there a genetic, evolution-driven, cause behind the restlessness of humanity?
At National Geographic, David Dobbs has an amazing long read digging into that idea. The story is fascinating, stretching from Polynesian sailors to Quebecois settlers. And it's very, very good science writing. Dobbs resists the urge to go for easy "here is the gene that does this" answers. Instead, he helps us see the complex web of genetics and culture that influences and encourages certain behaviors at certain times. It's a great read.
Not all of us ache to ride a rocket or sail the infinite sea. Yet as a species we’re curious enough, and intrigued enough by the prospect, to help pay for the trip and cheer at the voyagers’ return. Yes, we explore to find a better place to live or acquire a larger territory or make a fortune. But we also explore simply to discover what’s there.
“No other mammal moves around like we do,” says Svante Pääbo, a director of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, where he uses genetics to study human origins. “We jump borders. We push into new territory even when we have resources where we are. Other animals don’t do this. Other humans either. Neanderthals were around hundreds of thousands of years, but they never spread around the world. In just 50,000 years we covered everything. There’s a kind of madness to it. Sailing out into the ocean, you have no idea what’s on the other side. And now we go to Mars. We never stop. Why?”
Why indeed? Pääbo and other scientists pondering this question are themselves explorers, walking new ground. They know that they might have to backtrack and regroup at any time. They know that any notion about why we explore might soon face revision as their young disciplines—anthropology, genetics, developmental neuropsychology—turn up new fundamentals. Yet for those trying to figure out what makes humans tick, our urge to explore is irresistible terrain. What gives rise to this “madness” to explore? What drove us out from Africa and on to the moon and beyond?
When scientists from the Leibniz Institute of Plant Genetics and Crop Plant Research in Germany sequenced the genome of barley, they were thinking primarily about the impact on food. Understanding the genetics behind certain traits could help us breed barley varieties that have built-in resistance against disease, or that contain more fiber. (Contrary to popular understanding, there's actually a lot of overlap between what we might think of as genetic engineering and what we might think of as breeding. Crop researchers can use genome maps to select specific plants to cross pollinate, enabling them to reliably breed a trait into a new variety much faster than was previously possible.)
But, this is barley. And we don't just eat barley. With this plant, sequencing the genome also has implications for the way we brew beer. At Popular Science, Martha Harbison explains what we're learning about barley's genetic code and why it matters in beer making. In particular, she says it's significant that the researchers sequenced the genomes of more than one variety of barley.
Why should aspiring homebrewers care? Because two-row and six-row barley behave slightly differently in the mash, which can have profound effects on brewing efficiency and characteristics of the finished beer (a complex phenomenon I'll get into in a future column). I figured anyone nerdulent enough to want to know about genetic differences of cultivars would be curious as to which kind of barley was used in the single-nucleotide-variation study.
The cost of genome sequencing is starting to sink into the affordable range. (In comparison to its previous cost. We're talking "within reach" the same way Design Within Reach uses the phrase.)
Companies are starting to claim that a $1000 personal genome sequence is on the horizon. But what does that mean for you? Should you save up and get one? Can it really tell you anything meaningful at all? Who is going to sift through all the information your genome represents — and how will they do it?
Tonight, starting at 7:00 Eastern, Science Online New York City is hosting a round-table to discuss these issues, especially the problems associated with collecting, making sense of, and protecting a massive new stream of personal data. The live event is sold out, but you can watch whole thing streaming online.
Panelists: Ronald Crystal, the Chairman of the Department of Genetic Medicine at Weill-Cornell Medical College, who has had his genome sequenced and analyzed it himself. Virginia Hughes, a freelance author who has written about her experience with the 23andMe genotyping service. Manish Ponda of Rockefeller University, who has experimented with other -omic type analyses.
Via Lou Woodley
The Ninth Circuit is hearing arguments today about the privacy implications of gathering and retaining "junk" DNA, which has been treated as merely identifying, like a fingerprint, and not unduly invasive. Modern genetics shows that it's possible to extract information about health, ancestry, and other potentially compromising traits. From the Electronic Frontier Foundation's blog:
In this case, Haskell v. Harris, the ACLU of Northern California is challenging the California law, arguing that it violates constitutional guarantees of privacy and freedom from unreasonable search and seizure. This is the first court hearing to address DNA privacy since the research on “junk” DNA has become widely known, and in its role as amicus, EFF asked the court to consider the ground-breaking new research. The oral argument is open to the public at the federal courthouse at 95 7th Street in San Francisco. The hearing starts at 10am, in courtroom 1 on the third floor.