Having just finished a year of math and science heavy coursework, I am confident in stating that the Cambridge Quad Wirebound Notebook is one of the best tools I've used all year. Notebooks may seem like a silly thing to get worked up about, but having used this day-in and day-out for a year I can attest that it makes a difference.
When I first started looking for a notebook I was astonished by how much variety existed (especially in the world of graph paper), and consequently how much vitriol crappy notebooks generate. Everything from paper thickness to perforation was a potential sore spot. After field testing several varieties it was immediately clear that the Cambridge Quad was the winner.