We have sequenced the genomes of 17 supercentenarians (over 110 years of age) to see if we could uncover the genetic basis for their extreme longevity. We analyzed rare protein-altering variants, but found no strong evidence for enrichment of either a single variant or a single gene harboring different variants in female Caucasian supercentenarians compared to controls.
The full genomic sequences have been published, allowing other researchers to build on the data set.
I really enjoyed reading a recent story in The New York Times Magazine about attempts to understand extreme longevity — the weird tendency for certain populations to have larger-than-average numbers of people who live well into their 90s, if not 100s.
Written by Dan Buettner, the piece focuses on the Greek island of Ikaria, and, in many ways, it's a lot like a lot of the other stories I've read on this subject. From a scientific perspective, we don't really understand why some people live longer than others. And we definitely don't understand why some populations have more people who live longer. There are lots of theories. Conveniently, they tend to coincide with our own biases about what we currently think is most wrong with our own society. So articles about extremely long-lived populations tend to offer a lot of inspiring stories, some funny quotes from really old people, and not a lot in the way of answers.
Buettner's story has all those elements, but it also proposes some ideas that were, for me, really thought provoking. After spending much of the article discussing the Ikarian's diet (it's low in meat and sugar, high in antioxidants, and includes lots of locally produced food and wine) and their laid-back, low-stress way of life, Buettner doesn't suggest that we'll all live to be 100 if we just, individually, try to live exactly like the Ikarians do. In fact, he points out that other communities of long-lived individuals actually live differently — Californian Seventh-Day Adventists, for instance, eat no meat at all and don't drink, and they live with the normal stresses of everyday American life. Read the rest