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	<title>Boing Boing &#187; mistakes</title>
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		<title>Spotting science mistakes in the&#160;movies</title>
		<link>http://boingboing.net/2013/01/25/spotting-science-mistakes-in-t.html</link>
		<comments>http://boingboing.net/2013/01/25/spotting-science-mistakes-in-t.html#comments</comments>
		<pubDate>Fri, 25 Jan 2013 18:59:32 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Short]]></category>
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		<guid isPermaLink="false">http://boingboing.net/?p=208356</guid>
		<description><![CDATA[In <a href="http://boingboing.net/2013/01/25/hollywood-gets-science-wrong.html" title="Hollywood gets science wrong — and that's okay">the interview I posted earlier today</a>, SETI's Seth Shostak talked about how Hollywood has to make their science more accurate today than they did 40 years ago. That's because today's movie-watching tech makes it easier to spot flaws, and the Internet makes it easier to share them.]]></description>
			<content:encoded><![CDATA[In <a href="http://boingboing.net/2013/01/25/hollywood-gets-science-wrong.html" title="Hollywood gets science wrong — and that's okay">the interview I posted earlier today</a>, SETI's Seth Shostak talked about how Hollywood has to make their science more accurate today than they did 40 years ago. That's because today's movie-watching tech makes it easier to spot flaws, and the Internet makes it easier to share them. But different people notice different kinds of flaws, in different contexts. In a post from 2010, journalist Colin Schultz writes about<a href="http://colinschultz.wordpress.com/2010/11/10/learning-science-from-the-movies-the-effects-of-gender/"> a study that examined the differences between the kinds of scientific movie mistakes that men noticed, and the kind that women found</a>. Everybody saw the errors, but the context was different. ]]></content:encoded>
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		<title>A &quot;not insignificant&quot; defense of gleeful&#160;scientists</title>
		<link>http://boingboing.net/2012/11/29/a-not-insignificant-defens.html</link>
		<comments>http://boingboing.net/2012/11/29/a-not-insignificant-defens.html#comments</comments>
		<pubDate>Thu, 29 Nov 2012 20:08:33 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
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		<guid isPermaLink="false">http://boingboing.net/?p=197291</guid>
		<description><![CDATA[<p><a href="http://boingboing.net/wp-content/uploads/2012/11/6a00d8341bf67c53ef017ee5be193a970d.jpeg"><img src="http://boingboing.net/wp-content/uploads/2012/11/6a00d8341bf67c53ef017ee5be193a970d-600x485.jpeg" alt="" title="6a00d8341bf67c53ef017ee5be193a970d" width="600" height="485" class="alignnone size-medium wp-image-197311" /></a></p>

<p>Just a few minutes ago, researchers with NASA's MESSENGER mission announced the publication of data that strongly suggests the poles of Mercury contain significant quantities of frozen water.</p>

<p>On the one hand, this is not exactly <em>new</em> news. The possibility of water on Mercury has been a topic of research for something like 20 years.</p>]]></description>
			<content:encoded><![CDATA[<p><a href="http://boingboing.net/wp-content/uploads/2012/11/6a00d8341bf67c53ef017ee5be193a970d.jpeg"><img src="http://boingboing.net/wp-content/uploads/2012/11/6a00d8341bf67c53ef017ee5be193a970d-600x485.jpeg" alt="" title="6a00d8341bf67c53ef017ee5be193a970d" width="600" height="485" class="alignnone size-medium wp-image-197311" /></a></p>

<p>Just a few minutes ago, researchers with NASA's MESSENGER mission announced the publication of data that strongly suggests the poles of Mercury contain significant quantities of frozen water.</p>

<p>On the one hand, this is not exactly <em>new</em> news. The possibility of water on Mercury has been a topic of research for something like 20 years. And scientific discoveries tend to move in little mincing steps, not giant leaps, so there have been lots of previous announcements about evidence supporting the hypothesis of water of Mercury &mdash; including very similar announcements from the MESSENGER team <a href="http://news.nationalgeographic.com/news/2011/12/111214-water-ice-mercury-mars-moon-bright-poles-space-science/">in December 2011</a> and<a href="http://news.discovery.com/space/mercury-not-too-hot-for-water-ice-at-its-poles-120322.html"> March 2012</a>. Your life will not change in any significant way because there is frozen water on Mercury. You probably won't even make a note to tell your children where you were the day NASA announced that ice most likely existed there.</P>

<p>But that doesn't mean this news isn't damned exciting. And it doesn't mean that the scientists involved shouldn't be giddy about it. We are, after all, talking about a mission that sent a spacecraft into orbit around another planet and has quite likely found <em>frozen</em> water sitting on a landscape that is hot enough to melt lead. What's more, they think that ice is covered in places by a thin layer of some coal or tar-like organic material. That is huge news. It's going to change textbooks. And because the scientists think both the ice and the organic material got to Mercury via collisions with asteroids and comets, it's going to be an important part of our ongoing efforts to understand how life begins on planets like Earth.</p>

<p>All of this makes for a really nice, topical lead-in to an essay Robert Gonzalez published on iO9 today. It's totally reasonable to be frustrated by the recent whiplash of hearing that Curiosity discovered something "Earth-shattering" on Mars, only to have that announcement quickly revised to something "interesting" and/or "not insignificant". But, Gonzalez argues, it's also reasonable for scientists to look at something that is merely not insignificant from the public perspective and see it, from their own perspective, as groundbreaking. In fact, he says, we want more scientists who get excited about their work, not fewer.</p>

<span id="more-197291"></span>

<blockquote><p>Because here's the thing: I think it's a good thing when scientists are outwardly excited about their research. When someone like Grotzinger overstates the significance of a discovery, it reminds us that scientists are humans who are wholly invested in their work, and it makes their pursuits more relatable. I believe that the tendency among scientists to present themselves as dispassionate, robotlike, and wholly objective is boring and dishonest.</p>

<p>Granted, there are different ways to "expose one's humanity," and some are vastly preferable to others. Do we want researchers to engage in wholesale scientific fraud? Obviously not. But could scientists stand to be, for example, more outwardly enthusiastic about their work? Absolutely. Scientists, even the pompous ones, tend to undersell their findings, eschew "flowery" language, and feign complete objectivity — all under the banner of "good science."</p>

<p>But sometimes this approach is bullshit.</p></blockquote>

<p>Cutting through the bullshit means allowing scientists to be people. More importantly, it means allowing them to not just tolerate that process of inch-by-inch discovery ... but actively geek out about it.</p> 

<p>Gonzalez isn't trying to say that the researchers at the Jet Propulsion Laboratory couldn't have been more clear with reporters. From what we know about this misunderstanding it's pretty clear that mistakes happened on both sides. He's also not supporting intentional over-hype of results.</p>

<p>Instead, he thinks (and I agree) that scientists shouldn't pretend they're emotionless about the stuff they love. In fact, when combined with careful communication, that emotion can actually be an important part of helping the public understand science. When you're enthusiastic about your work, you spread that enthusiasm. In my experience, the scientists who the best job of making their work clear to lay people are the ones who are obviously hyped up about what they're doing &mdash; even if what they're doing isn't ever going to be front-page, above-the-fold news.</p>

<p>Besides, I don't only want to know what history books will think is important. I want to know what science thinks is important. And listening to scientists is the best way to find that out.</p>

<p><a href="http://io9.com/5964244/in-partial-defense-of-overzealous-scientists-a-reflection-on-martian-disappointments">Read Robert Gonzalez's essay on iO9</a></p>

<p><a href="http://news.discovery.com/space/organics-found-on-mercury-121129.html">Read more about today's news from the MESSENGER mission to Mercury</a></p>
]]></content:encoded>
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		<title>Fear and Trembling: Prion diseases on&#160;Twitter</title>
		<link>http://boingboing.net/2012/09/11/fear-and-trembling-prion-dise.html</link>
		<comments>http://boingboing.net/2012/09/11/fear-and-trembling-prion-dise.html#comments</comments>
		<pubDate>Tue, 11 Sep 2012 15:37:38 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
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		<guid isPermaLink="false">http://boingboing.net/?p=180374</guid>
		<description><![CDATA[Even if you don't immediately recognize the words "prion" or "Kuru", the history of these pathologies has seeped into popular culture like a horrifying fairy tale. But it's true: a tribe in New Guinea ate the dead, not as Hollywood-style savages but to respect the dead. Upon death, you took a part of them into yourself. And that included the brain.]]></description>
			<content:encoded><![CDATA[<p><a href="http://boingboing.net/wp-content/uploads/2012/09/kuru1.jpeg"><img src="http://boingboing.net/wp-content/uploads/2012/09/kuru1-600x538.jpeg" alt="" title="kuru1" width="600" height="538" class="aligncenter size-medium wp-image-180376" /></a></p>

<p>Even if you don't immediately recognize the words "prion" or "Kuru", the history has seeped into popular culture, like a horrifying fairy tale that just happens to be true. Once, there was a tribe in New Guinea that ate the dead. It wasn't the kind of fakey cannibalism you see in the movies, with hunters rushing out to spear people for sustenance. Instead, it was about respecting your elders. When a member of your family died, you ate them&mdash;you took a part of them into yourself. And that included the brain.</p>
<p>But over time, these people found themselves plagued with a terrible illness. Children and perfectly healthy adults, usually women, would suddenly begin to lose control of their limbs. They would jerk and shudder. Within weeks, they wouldn't be able to stand up at all. And then they died. Everybody who had those symptoms died. </p>
<p>Eventually, Western scientists would learn the awful truth. When the people from New Guinea ate their ancestors they were also eating a disease. It attacked their brains&mdash;riddling the tissue with holes. The New Guineans, the Fore people, called the disease kuru. In their language it meant "trembling" or "fear". </p>

<p>Today, we know a little bit more about the disease, kuru. We know it's not caused by a virus or a bacterium or a fungus. We know it's related to other brain-damaging diseases, including Creutzfeldt-Jakob disease, which turns healthy adults senile and kills them within a year of the onset of symptoms; scrapie, which affects sheep; and the dreaded bovine spongiform encephalopathy -- mad cow disease. </p>

<p>Tying all these diseases together is a scary little something called a prion. On August 16th, I attended a lecture by Jay Ingram, a Canadian journalist who has written a book about prion diseases, called <em>Fatal Flaws</em>. The lecture taught me a lot about prions, but it also taught me about some of the flaws inherent in trying to live-tweet a lecture as I'm listening to it. When the subject is so scary&mdash;and so confusing&mdash;even well-intentioned live tweets can go awry. </p>

<span id="more-180374"></span>

<p><script src="http://storify.com/maggiekb1/prion-thingie.js"></script><noscript>[<a href="http://storify.com/maggiekb1/prion-thingie" target="_blank">View the story "Fear and Trembling: Prion diseases on Twitter" on Storify</a>]<h1>Fear and Trembling: Prion diseases on Twitter</h1><h2>A public lecture introduced me to the terrifying world of mad cow disease and kuru. But to really understand what there was to fear, I had to dig deeper. </h2><p>Storified by Maggie Koerth-Baker &middot; Tue, Sep 11 2012 08:22:17</p><div>Drugline</div><div>You have probably heard this story before. Even if you don't immediately recognize the words "prion" or "Kuru", the history has seeped into popular culture, like a horrifying fairy tale, or an urban legend that just happens to be true. Once, there was a tribe in New Guinea that ate the dead. It wasn't the kind of fakey cannibalism you see in the movies, with hunters rushing out to spear people for sustenance. Instead, it was about respecting your elders. When a member of your family died, you ate them -- you took a part of them into yourself. And that included the brain.&nbsp;</div><div>But over time, these people found themselves plagued with a terrible illness. Children and perfectly healthy adults, usually women, would suddenly begin to lose control of their limbs. They would jerk and shudder. Within weeks, they wouldn't be able to stand up at all. And then they died.&nbsp;</div><div>Everybody who had those symptoms died.&nbsp;<br /></div><div>Eventually, Western scientists would learn the awful truth. When the people from New Guinea ate their ancestors they were also eating a disease. It attacked their brains --riddling the tissue with holes.&nbsp;The New Guineans, the Fore people, called the disease Kuru. In their language it meant "trembling" or "fear".&nbsp;</div><div>Prions show up as little brown specks on desktop microscope images of infected brain tissue. #banffscienceMaggie Koerth-Baker</div><div>Frontalcortex</div><div>That story is true. Mostly. It happened in the 1950s and 1960s. Today, we know a little bit more about the disease, kuru. We know it's not caused by a virus or a bacterium or a fungus. We know it's related to other brain-damaging diseases, including Creutzfeldt-Jakob disease, which turns healthy adults senile and kills them within a year of the onset of symptoms; scrapie, which affects sheep; and the dreaded bovine spongiform encephalopathy -- mad cow disease.&nbsp;</div><div>I'm at a @jayingram talk about his new book on prion diseases. #banffscienceMaggie Koerth-Baker</div><div>Tying all these diseases together is a scary little something called a prion. On August 16th, I attended a lecture by Jay Ingram, a Canadian journalist who has written a book about prion diseases, called <i>Fatal Flaws</i>. The lecture taught me a lot about prions, but it also taught me about some of the flaws inherent in trying to live-tweet a lecture as I'm listening to it.&nbsp;</div><div>Public lectures are fascinating introductions to a subject. Twitter is a great way to share information with people who can't be in the live audience. But they are both, by necessity, short summaries of much deeper stories. When you combine the two, it's easy to end up with a collection of snappy ideas, rather than a deep, context-laden narrative. And that can be the difference between education and sensationalism.<br />The tweets I wrote during Jay Ingram's lecture got a lot of attention. But as I looked at the questions and criticisms some of my readers had -- and as I started to read Ingram's actual book -- I realized that the missing context of Twitter might be leading people to conclusions that weren't correct. That's why I'm writing this up as a Storify. I want to take the disconnected ideas and fit them into a bigger whole. I also want to give you some things to think about the next time that I (or anybody else) live tweet a lecture.</div><div>Prions represent a revolution in the study of biology - starts in 1950s with kuru. - @jayingram #banffscienceMaggie Koerth-Baker</div><div>I tried to make it clear that I was quoting Ingram here. And, in general, most tweets from a lecture are quotes. But this is one of the places where it becomes difficult to understand the context. Am I, as the tweeter, telling you what I think? Am I simply relaying what was said by someone else? I can tell you what a speaker says, or I can tell you whether what that speaker is saying matches up with the bigger picture of evidence and opinion. The problem is that a live tweet of a public lecture can be a mixture of both. And knowing which perspective you're reading matters. Sometimes, it helps to ask before you re-tweet.&nbsp;</div><div>That's not to say that Ingram is incorrect in this quote. Prions do represent a revolution in how we think about biology. That's because prions are simply misfolded proteins.&nbsp;</div><div>Proteins are everywhere. Your body is built out of them. There are proteins in your cells that make the cells function. There are proteins in your hair, your skin, your muscles. Proteins control your metabolism, allowing you to turn a sandwich into energy. There are proteins in your brain.&nbsp;<br /></div><div>Every protein is made up of amino acids, the little molecular building blocks of biochemistry. In his talk, Jay Ingram had a really nice model that will help you visualize this stuff. Imagine a pearl necklace.&nbsp;</div><div>Natural Grey Freshwater Pearl Necklace ~ Accented with Rhodolite Garnets ~ Pearl Drop NecklaceNaomi King</div><div>Now, imagine that necklace twisted and turned, folded back on itself in a complex pattern.&nbsp;</div><div>Natural Grey Freshwater Pearl Necklace ~ Accented with Rhodolite Garnets ~ Pearl Drop NecklaceNaomi King</div><div>Protein folding is an incredibly complex process that happens in fraction of a second. And must be done perfectly. #banffscienceMaggie Koerth-Baker</div><div>That's what you should be thinking of when you think about proteins. At its most basic, a protein is just a chain of amino acids. But it gets its power -- an individual protein gains specific skills and tools -- because of how that chain is folded. In some ways, that's a great system. It allows you to do more things with the same set of tools, as if your screwdriver could suddenly become a hammer.<br /></div><div>The catch: The same protein can act in very different ways, depending on how it's folded.&nbsp;</div><div>Healthy human brains have &quot;prion proteins&quot; on surface of neurons. Nobody is sure what they do yet. #banffscienceMaggie Koerth-Baker</div><div>Healthy prion protein has a tendency to misfold. When it does, it can touch off infectious process and spread misfolding. #banffscienceMaggie Koerth-Baker</div><div>To demonstrate this, @jayingram throws a sprung mousetrap into a batch of set ones ... so they all spring too. #banffscienceMaggie Koerth-Baker</div><div>So there's a nice, healthy protein that sits on the surface of the neuron cells in your brain. Nobody knows what, exactly, it does. But prions seem to be this same protein, folded up all wrong. And that's the revelatory part.&nbsp;</div><div>All that stuff I told you about proteins is basic biology. Nobody questions that. But as they studied kuru, scientists began to see evidence of something a lot more controversial -- the idea that misfolded proteins could&nbsp;<i>cause</i>&nbsp;deadly disease, and that the disease could be spread by the misfolded proteins, themselves. Somehow, they think, misfolded proteins trigger healthy proteins to also misfold. This idea is way out in left field compared to everything we thought we knew about how disease works. It's still not 100% proven. In fact, there are researchers who think misfolded proteins are only a mere symptom of mad cow and other prion diseases -- not their cause. There's a lot we don't know. But it does seem like, the more scientists study this, the more evidence appears supporting the theory that prions -- misfolded proteins -- can make more of themselves and can, together, make people and animals sick.&nbsp;</div><div>Wow. @jayingram showing 1950s era video of kuru victims. Only affected motor neurons. Still alert. But couldn't move. #banffscienceMaggie Koerth-Baker</div><div>When I say that there's a lot we don't know, I mean A LOT. For instance, we have microscopes that can see healthy proteins, but we can't get a good look at a prion. That's because, when proteins misfold, they seem to immediately start clumping together, like one of those magnetic desk toys. We can't see any of the individual units that make up that mess. Which means that when we talk about prions we are talking about something we have not yet directly observed.&nbsp;<br /></div><div>Here's another example of how little we know when it comes to prions: As I mentioned in the tweet above, the effects of kuru are centered around the&nbsp;control of limbs. Victims jerk and writhe. Slowly, they lose the ability to walk. But they're lucid and cognitively normal right up until the end. Victims of mad cow disease, on the other hand, have severe problems with memory. They experience hallucinations.&nbsp;</div><div>Video of cow with mad cow, terrified of hallucinated threats is heartbreaking. #banffscienceMaggie Koerth-Baker</div><div>Jay Ingram wasn't able to get in touch with the researchers who own this video, so I can't share it with you here. But here's what I saw: A cow running aimlessly around its paddock, stopping short in fear of non-existent terrors&nbsp;and hopping over obstacles that weren't actually there. I've never seen an animal behave this way, and it looks nothing like the video of kuru. But the theory is that both these diseases involve the&nbsp;same protein from the surface of neurons.&nbsp;<br /></div><div>Why would the same misfolded protein cause such very different symptoms? &nbsp;That's a question we don't have an answer for. When I interviewed him after the lecture, Jay Ingram told me that the best guess that the difference has to do with the structure we can't see.&nbsp;</div><div>"They’re all misfolded, but in different ways. That’s the assumption," he said. "Supposedly that also accounts for the so-called species barrier when it happens. People eat sheep meat infected with scrapie all the time&nbsp;and never get ill. Structural differences probably account&nbsp;for that, and also probably account for where in the brain the damage happens. It’s not a great explanation though, because you can't get details yet on the structure, on how they misfold."&nbsp;</div><div>Early #FF to @maggiekb1, because she's scaring the crap out of me with her live tweets right now.Alex Knapp</div><div>Fair enough. I'm scaring myself, too. Now, on to the cannibalism.&nbsp;</div><div>Australian miners and laborers guessed kuru was related to cannibalism before scientists did.#banffscienceMaggie Koerth-Baker</div><div>Of course, those miners weren't prescient or anything. They just got lucky in this prediction. Their prejudices against the Fore happened to overlap with the actual mode of transmission. Or, anyway, with what scientists are pretty sure was the actual mode of transmission.&nbsp;<br /></div><div>Because here's another thing you need to remember about public lectures: They're edited for time and they're edited to tell a compelling story. There are always details that get left out. And you can see this in the difference between Jay Ingram's lecture and his book. In the lecture, he went with the general consensus: Kuru spread among the Fore because they were eating the brains of kuru victims and ingesting prions. But in the book, he explains why this story can't be said to be the unquestionable truth.&nbsp;<br /></div><div>Lots of Western doctors and anthropologists wrote about the Fore eating their dead. But none of those people actually&nbsp;<i>saw</i>&nbsp;them do it. In fact, there's very little direct evidence for cannibalism among the Fore. Scientists believe it happened, though, for two reasons. First, the Fore say it happened. And there's not really an obvious benefit to lying about eating your dead grandmother. Second, it just makes sense. Most prion diseases are not very easy to transmit. Directly eating infected tissue is one of the few ways to do it. Plus, the Fore say they began eating their dead in the early 20th century and that kuru only started killing people after that. And we know that cases of kuru tapered off to almost nothing as soon as the Fore say they&nbsp;stopped eating their dead in the 1950s. But we don't know for sure. It's a story that's never been independently verified.&nbsp;</div><div>Square Cowadrian fu</div><div>British govt suppressed connection between mad cow and scrapie when first noticed. Hid data for four years. #banffscienceMaggie Koerth-Baker</div><div>.@maggiekb1 UK minister at time notoriously fed his young daughter a burger on TV to show editing beef was 'safe'. Not his proudest momentAnsonMackay</div><div>That's true. British scientists noticed that there were similarities between the brains of victims of mad cow disease, the brains of sheep infected with scrapie, and the brains of kuru victims. But the government worried that publishing that information could decimate the beef industry. Because the scientists worked for the government, the government was able to prevent them from publishing their work. You can read all about this in several volumes of The BSE Inquiry Report, published in 2000.&nbsp;</div><div>[ARCHIVED CONTENT] The BSE Inquiry Report: HomeThis site is an archive of the BSE Inquiry. It is no longer being updated and some   links from the site may no longer work. This site co...</div><div>At the peak, in 1993, 45,000 British cows were dying per year. #madcow #banffscienceMaggie Koerth-Baker</div><div>Somewhat reasonable that they didn't suspect risk to humans at first; scrapie has never infected ppl. #madcow #banffscienceMaggie Koerth-Baker</div><div>Cow disease peaked in 1993. Human disease peaked 2001. But incubation period was a decade. #banffscienceMaggie Koerth-Baker</div><div>One woman who died of mad cow had been a vegetarian for 8 years. #banffscienceMaggie Koerth-Baker</div><div>“@maggiekb1: One woman who died of mad cow had been a vegetarian for 8 years. #banffscience”'Splain THAT one!Diana McIntosh</div><div>@dianamcintosh that shows you how long the incubation period is.Maggie Koerth-Baker</div><div>The incubation period for prion diseases is another thing we don't understand very well. I mentioned that kuru cases dropped off to "almost nothing" after the Fore say they stopped practicing cannibalism. I worded it that way for a reason. No Fore born after 1960 has ever developed kuru. But people who were alive during the time when cannibalism happened do still occasionally die from the disease. In his book, Ingram notes that 11 people died from kuru between 1996 and 2004. Assuming they were infected before 1960, that gives them a good 40-odd years of living, symptom-free with an incubating prion disease.&nbsp;<br /></div><div>But why would some people, including children, die within a few years of exposure, while others lived to a ripe old age?&nbsp;I asked Jay Ingram about this. He told me there are two factors that likely account for the wide variety of incubation periods we see in prion diseases.</div><div>First, it might have to do with how well-adapted the prions are to their host species. Some prion diseases -- like mad cow -- seem to be able to jump from one species to another. Mad cow can infect cows, and humans ... and cats. In fact, Ingram told me that it was the death of a housecat named Max in 1990 that really got people seriously considering the idea that mad cow wasn't limited to <i>cows</i>.&nbsp;<br /></div><div>But it does seem like prions can get better at infecting a specific species over time. You can infect a mouse with mad cow disease from a cow, Ingram told me. And if you take the brain of that mouse and use it to infect more mice, something weird starts to happen.&nbsp;<br /></div><div>"If you continue in the lab and infect mice, and then infect more mice, eventually the incubation period seems to start to shrink," he said. Nobody understands why that happens. But it could be a form of adaptation as the prions "figure out" how to better infect a new species. Basically, it could be a form of natural selection. Remember, we can't see the prion, itself. There's a possibility that every prion disease actually represents a variety of specific types of protein misfoldings. In a new a host, a previously small-potatoes type of misfold could turn out to be a better match for the host's proteins. Over several generations of infection, that type could come to dominate the mix, allowing the infection operate more efficiently.&nbsp;</div><div>Genetics might also affect how long it takes an individual person to develop symptoms of a prion disease. Remember that healthy prion proteins --&nbsp;the ones we all have on the surface of our neurons&nbsp;-- are long chains of amino acids. It seems to be very important to have specific amino acids at a specific place in the chain.&nbsp;<br /></div><div>The place is called position 129. There are two amino acids at this spot and what pairing you get is determined by who your parents are. You can have two&nbsp;methionine amino acids, two valine amino acids, or one of each.&nbsp;<br /></div><div>"That seems to determine resistance to prion diseases," Ingram said. "We know that people who are heterozygous, with a methionine-valine pair, were most resistant for kuru. For instance, a lady who was incubating it for 50 years was methionine-valine."</div><div>Again, we don't know for certain what's going on here, but there seems to be evidence that some people are more susceptible to prion diseases than others. And that has implications for mad cow disease. The peak of human deaths has long since passed. But there's a possibility that that was only the first peak -- as the most susceptible people died. Others could still be carrying the disease.</div><div>&nbsp;"We don’t know whether it will someday pop up again," Ingram said. "And we don't know, if people are carrying it, whether the incubation period will turn out to be long enough that they all die of something else first."</div><div>Today, though, mad cow is no longer the most critical prion disease to pay attention to.&nbsp;</div><div>Elk SculptureInAweofGod'sCreation</div><div>What is the most important prion disease today? @jayingram say chronic wasting disease in deer and moose. #banffscienceMaggie Koerth-Baker</div><div>CWD is different than mad cow. Terrifyingly so. Not just brain is infectious. Saliva, flesh, bones, the soil a deer dies on. #banffscienceMaggie Koerth-Baker</div><div>Normally, it's not easy to get a prion disease. We're talking about something that infects the brain, and passing it on usually requires direct contact. Kuru was probably spread when people ate the infected brains of other people. Mad cow passed from cow to cow via "protein meal" -- a cattle feed made from scrap meat like brain and nervous system tissue. Humans most likely&nbsp;picked up mad cow from nervous system tissue in ground hamburger meat. Creutzfeldt-Jakob disease, which appears spontaneously in humans, is probably linked to unlucky genetics. But it has been spread from person-to-person in the past by surgical transplants of brain dura matter. &nbsp;<br /></div><div>Chronic wasting disease (CWD) is different. It's spreading among wild deer, but they aren't getting invasive brain surgery. They aren't eating each other's brains. And&nbsp;they're dying anyway. It's not exactly clear how this is happening, but researchers have found prions in deer saliva. It's present in urine and feces. And deer have become infected simply by having contact with the bones of a deer that died from CWD, or the ground the bones were lying on. Meanwhile, scrapie, the sheep disease, has been known to hide out in the soil, too. Sheep have been infected by grazing on land that played host to a scrapie outbreak&nbsp;<i>two years</i>&nbsp;before.&nbsp;<br /></div><div>Which, of course, brings up an interesting question: Is CWD transmissible to humans?&nbsp;</div><div>Annnnnd, there goes my love of summer sausage. #banffscienceMaggie Koerth-Baker</div><div>Firefighters in rural New York accidentally served CWD infected deer to 80 ppl. Five yrs gone by. So far, so good. #banffscienceMaggie Koerth-Baker</div><div>.@maggiekb1 eek! 80 people with potentially infectious saliva?Adam Kent</div><div>Another problem with live-tweeting public lectures: Not everything from the lecture makes it to the tweets. I type quickly. But I don't type<i> that </i>quickly. Sometimes, what gets left out ends up being important. This is one of those times.&nbsp;</div><div>On March 13, 2005, more than 200 people attended the Sportsman's Feast, hosted by a fire company in Oneida County, New York. By that point, CWD had already been detected in local deer populations so any deer harvested from a domestic deer farm -- like the ones eaten at the Sportsman's Feast -- had to be tested. Unfortunately, there were no laws preventing the meat from being fed to anyone before the test results came back. People only found out that one of the deer had CWD after the feast was already over.&nbsp;</div><div>Since then, 81 of the people who went to the feast have agreed to participate in long-term monitoring. In 2008, researchers published a study documenting various risk factors: Who ate the deer meat and what parts did they eat; who was involved in cooking; did they wear gloves; that kind of thing. The study also documents any risk factors that happened outside the 2005 feast. For instance, whether or not any of the participants are regular hunters. If, someday, any of these people<i> do</i> start dying of prion diseases, researchers will be able to look back at this data and learn a lot more about whether the prion disease in question is likely to be CWD and, if so, which activities are risky and which aren't.&nbsp;</div><div>Environmental Health | Full text | Risk behaviors in a rural ...... one and can be found online at: http://www.ehjournal.net/content/7/1/31 ... (http:  //creativecommons.org/licenses/by/2.0), which per...</div><div>The really important information is at the end of that paper. Turns out, there's good reason to think that CWD is not transmissible to humans at all.&nbsp;</div><div>The Sportsman's Feast research is an ongoing, observational study. Researchers are watching these people to see what happens to them. But there are other ways you can study something like this. In 2001 and 2006, other scientists published papers that looked backwards in time, to see if they could spot any evidence that CWD is already affecting humans.&nbsp;</div><div>Creutzfeldt-Jakob disease in unusually young patients who consumedArch Neurol. 2001 Oct;58(10):1673-8. Creutzfeldt-Jakob disease in unusually   young patients who consumed venison. Belay ED, Gambetti P, ...</div><div>The first of these two studies looked at three people who died of Creutzfeldt-Jakob disease while extraordinarily young -- all before the age of 31. Dying that young of Creutzfeldt-Jakob can be a sign that the victims acquired their prion disease from another source. (That was the case with mad cow disease.) But it doesn't necessarily mean that. It could just be that these people were extraordinarily unlucky. Their healthy prion proteins just shifted into prions spontaneously.&nbsp;</div><div>In fact, that's what researchers think happened. Even though all three had regularly eaten deer meat during their lives (two were hunters and one was the daughter of a hunter) their illnesses looked more like classic, spontaneous Creutzfeldt-Jakob than any acquired prion disease. For instance, we already talked about how people who die quickly from acquired prion diseases tend to share a particular pairing of amino acids at Position 129 in their prion protein. None of these people had that.&nbsp;</div><div>Human prion disease and relative risk associated with chronic wastingEmerg Infect Dis. 2006 Oct;12(10):1527-35. Human prion disease and relative   risk associated with chronic wasting disease. Mawhinney S, ...</div><div>The second study evaluated 22 years' worth of death certificates from counties in Colorado where CWD is endemic. Looking at hunting licenses, the researchers knew that people who hunted in those counties also tended to live in those counties. So, if people who lived there were more likely to die from from Creutzfeldt-Jakob disease than people who lived in other counties in the state, that might be a sign that hunters and their families were quietly acquiring CWD from the deer they killed and ate.&nbsp;</div><div>But the researchers saw no difference between the people who lived in counties with lots of CWD and those who didn't. What's more, rates of Creutzfeldt-Jakob disease in CWD-infected counties haven't gone up over time. Together, these results suggest that humans can't be infected with CWD. It's not absolute proof. Personally, I'm still feeling a little squeamish about eating venison. But it tells us that there's a pretty good chance all those people in New York (and whoever they've been kissing for the past seven years) are going to be okay.&nbsp;</div><div>That's not to say there's no reason to worry about the effects of CWD. We're still talking about a disease that could drive deer and elk in North America to extinction. If that happens, it'll have big impacts on the food chain, human culture, and economic activity -- especially in parts of Canada where people rely on these animals for food. But those are different concerns than a killer disease that can be spread by saliva.&nbsp;</div><div>ποντίκι / μυς, mouse (Mus musculus) by George Shuklindullhunk</div><div>Finally, we need to talk about mice. Lab mice, specifically.&nbsp;</div><div>In Jay Ingram's lecture, I learned that scientists have been using mice to study some interesting connections between exotic prion diseases and far more common illnesses, including&nbsp;Alzheimer's disease. This is a good example of why tweeting a public lecture can be really tricky. The ideas I'm talking about here aren't crazy. They aren't conclusions promoted by fringe scientists who don't know what they're doing. But it's also really, really easy to blow these particular ideas out of proportion. In a space like Twitter, the act of discussing interesting early findings can very quickly turn into accidental fear-mongering. Especially when the tweeter (in this case, me) hasn't heard about the research before.&nbsp;</div><div>ALS, parkinsons, alzheimers are all also related to misfolded proteins, though not prions. Could still be infectious ... #banffscienceMaggie Koerth-Baker</div><div>Brain material from human alzheimer patient injected into healthy mice equals mice with same kind of misfolded proteins #banffscienceMaggie Koerth-Baker</div><div>There is a lot we don't know. But medical world is starting to look at connections between prion disease and alzheimers. #banffscienceMaggie Koerth-Baker</div><div>So, is alzheimers infectious? Researchers say &quot;welll probably not. But might not have done right epidemiology&quot; @jayingram #banffscienceMaggie Koerth-Baker</div><div>@Lewis_Lab @maggiekb1 Suggesting AD is infectious is incredibly dangerous and possibly damaging to patient care. Grammy WILL NOT give you ADDarren Boehning</div><div>Darren Boehning is right. But, at the same time, my tweets (and Jay Ingram's speech) aren't incorrect.&nbsp;</div><div>There really is evidence that Alzheimer's disease (along with a host of other disorders, including, believe it or not, Type 2 diabetes) might be related to protein misfolding, and that these misfolded proteins can create more misfolded proteins and spread through a brain -- just like prions do. In these cases, the proteins being misfolded aren't the same ones as in prion diseases. But the misfolded&nbsp;proteins do seem to be able to spread from one part of a person's brain to another. For instance, in people with Parkinson's disease who received grafts of healthy brain tissue, the misfolded proteins involved in Parkinson's appeared in the donor tissue ten years later. Nobody knows how that could happen, unless the misfolded proteins spread on their own by converting healthy proteins, the same way that prions spread.&nbsp;&nbsp;</div><div>And there have been several animal studies that suggest it might be possible to transmit Alzheimer's from one individual to another by injecting infected brain material into a second animal. These aren't perfect studies. For instance, this research has mostly been done in mice, which aren't the ideal models of human disease. And only one study -- conducted by Claudio Soto at the University of Texas -- has been done in mice that weren't already genetically engineered to be more susceptible to Alzheimer's.&nbsp;<br /></div><div>We need more information. But we have enough information to know that this isn't something we can just brush off. In May 2012, the New England Journal of Medicine published an article that will give you a good overview of this research.&nbsp;</div><div>The Spread of Neurodegenerative Disease — NEJMMay 31, 2012 ... Clinicians who care for patients with neurodegenerative disease often believe   that their patients&amp;#39; diseases are sp...</div><div>Alzheimer's and mad cow might operate in similar ways, but they are two very different things. And, as far as anybody can tell, Alzheimer's disease is not being spread from person to person.</div><div>Jay Ingram said the researchers he spoke with didn't think Alzheimer's was contagious, but they also thought the right kinds of epidemiological studies hadn't been done to really know for sure. That matters, because "as far as anybody can tell" only covers what we can see. If we haven't done the right kinds of studies, we could easily be missing evidence.&nbsp;</div><div>When&nbsp;Ingram&nbsp;that, one of the researchers&nbsp;he had in mind was Neil Cashman, a neurologist and neuroscientist at the University of British Columbia. I spoke with Cashman for this story and asked him what the "right kind" of study would look like.&nbsp;</div><div>For one thing, he said, it would take a long time to do. His ideal scenario would be to look at blood donors and recipients. Researchers could find older donors, who later turned out to have Alzheimer's, and then follow what happened to the people who received that donated blood. You'd have to follow the recipients for 20 years or so, he said, but in the end you'd have the information you need to get an idea of whether receiving blood from an Alzheimer's victim increased your risk of getting it. Without a study like that, we really don't know whether Alzheimer's can spread from person to person or not.&nbsp;</div><div>But what does that mean for caregivers now? We're swimming in a sea of scary studies, none of which are yet telling us enough to know much about real-world risks. It's completely possible that all these little clues could end up not being clues to anything, at all. Sometimes things happen in the lab that don't happen in reality. Sometimes we see patterns where patterns don't actually exist.&nbsp;</div><div>Cashman says it puts researchers, doctors, and (yes) journalists in a difficult position. "We’re trained not to alarm people with unproven possibilities," he said. "One side of me says it’s not a good idea to publish or even discuss the&nbsp;possibility that Alzheimer's&nbsp;is transmissible. But another part of me says there’s a legitimate public health concern here.&nbsp;Where’s the balance between not&nbsp;panicking&nbsp;people, but giving them enough information to know that this is something that really needs to be investigated? Right now, there's not enough evidence to worry about it. But there's not enough evidence to not worry about it, either."&nbsp;</div><div>On the plus side, he said, if Alzheimer's<i> is</i> actually infectious, it's probably nowhere near as infectious as prion diseases like mad cow. You can see that just by looking at the epidemiological data we do have, Cashman said. "You didn't need a lab to tell you that Chronic Wasting Disease and kuru were incredibly contagious. That was clear from the patterns of infection," he said. "With Alzheimer's, if it is contagious it must be much less contagious. Otherwise, we’d see much larger outbreaks of Alzheimer's happening,&nbsp;and it would be clear from day one."</div><div>&nbsp;Basically: Alzheimer's is not like Chronic Wasting Disease. Unfortunately, from reading my twitter posts, it was easy to get the impression that it might be. The information about the two topics just came too close to each other. Implications happened: Whether I meant them to or not.&nbsp;</div><div>Even the best-intentioned live tweets can be misleading.&nbsp;</div><div>I'm not exactly sure what I'm going to do with this realization, myself. I enjoy live-tweeting at conferences and lectures. From my perspective, it seems like the people who read my Twitter stream enjoy it, too. But, clearly, there are downsides I had not previously considered. I'll be thinking about it. But, when you read Twitter, you should think about it, too.&nbsp;</div><div>Read Jay Ingram's book:&nbsp;</div><div>Fatal Flaws: Amazon.ca: Jay Ingram: BooksMost people have never heard of prions. Indeed, most are only barely aware of   the diseases caused by them, except, perhaps, for mad cow...</div><div>Another good story to check out:&nbsp;</div><div>Infectious proteins on the brain: Alzheimer&amp;#39;s and prions | SmartPlanetFeb 21, 2012 ... Scientists seeking to understand the fundamental pathology of Alzheimer&amp;#39;s   disease have long debated the merits of ...</div></noscript></p>]]></content:encoded>
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		<title>How Smokey Bear creates forest&#160;fires</title>
		<link>http://boingboing.net/2012/08/23/how-smokey-bear-creates-forest.html</link>
		<comments>http://boingboing.net/2012/08/23/how-smokey-bear-creates-forest.html#comments</comments>
		<pubDate>Thu, 23 Aug 2012 17:26:43 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Post]]></category>
		<category><![CDATA[climate change]]></category>
		<category><![CDATA[fires]]></category>
		<category><![CDATA[forests]]></category>
		<category><![CDATA[History]]></category>
		<category><![CDATA[humans]]></category>
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		<guid isPermaLink="false">http://boingboing.net/?p=177849</guid>
		<description><![CDATA[<p><a href="http://boingboing.net/wp-content/uploads/2012/08/forestfire.jpeg"><img src="http://boingboing.net/wp-content/uploads/2012/08/forestfire.jpeg" alt="" title="forestfire" width="640" height="581" class="aligncenter size-full wp-image-177867" /></a></p>

<p>By now, many of you are probably aware that human behavior is one of the key factors behind some of the massive forest fires we've seen in recent years. The basic story goes like this: Under a natural cycle, periodic small fires sweep through forests, burning through small trees and dry brush.</p>]]></description>
			<content:encoded><![CDATA[<p><a href="http://boingboing.net/wp-content/uploads/2012/08/forestfire.jpeg"><img src="http://boingboing.net/wp-content/uploads/2012/08/forestfire.jpeg" alt="" title="forestfire" width="640" height="581" class="aligncenter size-full wp-image-177867" /></a></p>

<p>By now, many of you are probably aware that human behavior is one of the key factors behind some of the massive forest fires we've seen in recent years. The basic story goes like this: Under a natural cycle, periodic small fires sweep through forests, burning through small trees and dry brush. But if you prevent those fires from happening&mdash;as humans have done for around a century at this point&mdash;all that highly flammable stuff builds up. In the end, you're left with a giant tinderbox of a forest. The next time a fire does happen there, it's almost guaranteed to be much, much bigger and more destructive than the natural fires that forest is adapted to.</p>

<p>NPR has a very nice story about the science and history behind this problem, which forest fire experts call "The Smokey Bear Effect", after the cartoon Ursus the U.S. Forest Service has long used as part of its fire prevention campaign.</p>

<p>Its ill-advised fire prevention campaign.</p>

<blockquote><p>And it was the experts who approved the all-out ban on fires in the Southwest. They got it wrong. That's the view of fire historian Stephen Pyne.</p>

<p>"The irony here is that the argument for setting these areas aside as national forests and parks was, to a large extent, to protect them from fire," Pyne says. "Instead, over time they became the major habitat for free-burning fire."</p>

<p>So instead of a few dozen trees per acre, the Southwestern mountains of New Mexico, Arizona, Colorado and Utah are now choked with trees of all sizes, and grass and shrubs. Essentially, it's fuel.</p>

<p>Over the past several years, even as fewer fires have struck the Southwest, they've burned more land. The U.S. Forest Service now spends about half its budget on firefighting.</p></blockquote>

<p>It's worth noting that this is also a great example of why it's difficult to attribute specific events to global climate change. Increasingly hot, dry summers have certainly been a factor in creating the forest fires we've seen over the last few years. The last decade has been the hottest on record, and that has consequences. But it's not the only thing going on here. Climate change doesn't happen in a vacuum. Its effects interact with the effects of other decisions we make (and other natural events that happen to be taking place). So it's not enough to say what climate change will do. In order to make accurate predictions of risk, we have to think about the bigger picture and how climate change fits into it.</p>

<p><a href="http://www.npr.org/2012/08/23/159373691/how-the-smokey-bear-effect-led-to-raging-wildfires">Read (or listen to) the rest of the story at NPR's website</a></p>

<em><P>Via <a href="https://twitter.com/finnryan">Finn Ryan</a></p></em>

<p><small>Image: <a href="http://www.flickr.com/photos/wandrus/4736578202/">Forest Fire</a>, a Creative Commons <a href="http://creativecommons.org/licenses/by/2.0/deed.en">Attribution (2.0)</a> image from wandrus's photostream</small></p>]]></content:encoded>
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		<title>Wikipedia&#039;s list of infamous software&#160;glitches</title>
		<link>http://boingboing.net/2012/08/06/wikipedias-list-of-infamous.html</link>
		<comments>http://boingboing.net/2012/08/06/wikipedias-list-of-infamous.html#comments</comments>
		<pubDate>Mon, 06 Aug 2012 20:24:10 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Short]]></category>
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		<guid isPermaLink="false">http://boingboing.net/?p=175074</guid>
		<description><![CDATA[Worth noting, especially if you read <a href="http://boingboing.net/2012/08/03/blackout-whats-wrong-with-t.html" title="Blackout: What's wrong with the American grid">my piece last Friday</a> about problems with America's electric infrastructure: <a href="https://en.wikipedia.org/wiki/List_of_software_bugs#Electric_power_transmission">Wikipedia's list of infamous software glitches  </a>includes the problems with General Electric Energy's XA/21 monitoring software that helped make the 2003 East Coast Blackout happen.]]></description>
			<content:encoded><![CDATA[Worth noting, especially if you read <a href="http://boingboing.net/2012/08/03/blackout-whats-wrong-with-t.html" title="Blackout: What's wrong with the American grid">my piece last Friday</a> about problems with America's electric infrastructure: <a href="https://en.wikipedia.org/wiki/List_of_software_bugs#Electric_power_transmission">Wikipedia's list of infamous software glitches  </a>includes the problems with General Electric Energy's XA/21 monitoring software that helped make the 2003 East Coast Blackout happen. <em>(Via <a href="https://twitter.com/kcimc">Kyle McDonald</a>)</em>]]></content:encoded>
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		<title>How early electric experiments destroyed the University of Missouri&#039;s main academic&#160;hall</title>
		<link>http://boingboing.net/2012/06/05/how-early-electric-experiments.html</link>
		<comments>http://boingboing.net/2012/06/05/how-early-electric-experiments.html#comments</comments>
		<pubDate>Tue, 05 Jun 2012 19:58:07 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Post]]></category>
		<category><![CDATA[electricity]]></category>
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		<category><![CDATA[mistakes]]></category>
		<category><![CDATA[oops]]></category>
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		<category><![CDATA[Technology]]></category>

		<guid isPermaLink="false">http://boingboing.net/?p=164840</guid>
		<description><![CDATA[<p><iframe width="600" height="338" src="http://www.youtube.com/embed/-3jkcwMUoqg" frameborder="0" allowfullscreen></iframe></p>

<p>I'm completely fascinated by stories from the early days of electricity ... specifically, stories of experiments that went horribly (and sometimes, comically) wrong.</p>

<p>For me, it's a great reminder that, no matter how much of a sure-thing a technology like electricity seems in retrospect, there was always a point in history where the future was uncertain, where mistakes were made, and where even the "experts" didn't totally know what they were doing.</p>]]></description>
			<content:encoded><![CDATA[<p><iframe width="600" height="338" src="http://www.youtube.com/embed/-3jkcwMUoqg" frameborder="0" allowfullscreen></iframe></p>

<p>I'm completely fascinated by stories from the early days of electricity ... specifically, stories of experiments that went horribly (and sometimes, comically) wrong.</p>

<p>For me, it's a great reminder that, no matter how much of a sure-thing a technology like electricity seems in retrospect, there was always a point in history where the future was uncertain, where mistakes were made, and where even the "experts" didn't totally know what they were doing. In general, I think it's good to remind ourselves that the real history of innovation is a lot messier than high-school level textbooks make it out to be.</p>

<p>In this short video, retired University of Missouri engineering professor Michael Devaney tells the tale of how a group of engineering students&mdash;armed with an early-model Edison electric generator&mdash;burned  their school's main academic building to the ground. At the heart of the disaster: An attempt to see how many light bulbs the generator could light at once. To paraphrase Devaney, everything was going okay until the fire reached the ROTC's supply of cannon powder.</p>

<p>Read about <a href="http://boingboing.net/2010/03/25/how-thomas-edison-se.html">how Thomas Edison himself set W.H. Vanderbilt's living room on fire</a>.</p>

<p>Read about <a href="http://boingboing.net/2010/03/26/the-ongoing-mis-adve.html">Thomas Edison and his staff accidentally turning a New York City intersection into a giant joy buzzer</a>.</p>

<p>Read more on <a href="http://www.nytimes.com/interactive/2012/06/03/magazine/innovations-issue.html">my thoughts about the messy history of innovation</a>, published in last weekend's <em>New York Times Magazine</em>.</p>

<em><p>Thanks to Robert Solorzano and <a href="http://web.missouri.edu/~zhwc6/quad/engineering.html">The Missourian</a> for the tip on this story!</p></em>]]></content:encoded>
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		<slash:comments>13</slash:comments>
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		<title>Car heads down subway&#160;stairs</title>
		<link>http://boingboing.net/2012/04/24/car-heads-down-subway-stairs.html</link>
		<comments>http://boingboing.net/2012/04/24/car-heads-down-subway-stairs.html#comments</comments>
		<pubDate>Tue, 24 Apr 2012 15:04:39 +0000</pubDate>
		<dc:creator>Rob Beschizza</dc:creator>
				<category><![CDATA[Wide]]></category>
		<category><![CDATA[cars]]></category>
		<category><![CDATA[mistakes]]></category>
		<category><![CDATA[paris]]></category>

		<guid isPermaLink="false">http://boingboing.net/?p=156366</guid>
		<description><![CDATA[<p><img src="http://boingboing.net/wp-content/uploads/2012/04/RTR3155X.jpg" alt="" title="RTR3155X" class="alignnone bordered size-full wp-image-156367" />

<br />A driver tried to drive into the Chaussee d'Antin La Fayette Metro station in Paris on Tuesday, reportedly having mistaken it for a subterranean parking garage. The driver, who gave his name as Johan, told AFP: "There's a sign saying 'Haussmann Parking' right in front (of the Metro entrance), and ...</p>]]></description>
			<content:encoded><![CDATA[<p><img src="http://boingboing.net/wp-content/uploads/2012/04/RTR3155X.jpg" alt="" title="RTR3155X" class="alignnone bordered size-full wp-image-156367" />

<br />A driver tried to drive into the Chaussee d'Antin La Fayette Metro station in Paris on Tuesday, reportedly having mistaken it for a subterranean parking garage. The driver, who gave his name as Johan, told AFP: "There's a sign saying 'Haussmann Parking' right in front (of the Metro entrance), and ... I made a mistake."

<p><a href="http://www.france24.com/en/20120424-parisian-drives-car-down-metro-stairs">Parisian drives car down Metro stairs</a> [AFP. <em>Photo: REUTERS/Jacky Naegelen</em>]
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		<slash:comments>42</slash:comments>
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		<title>Thought-provoking essay on cause and correlation in modern&#160;science</title>
		<link>http://boingboing.net/2012/01/04/thought-provoking-essay-on-cau.html</link>
		<comments>http://boingboing.net/2012/01/04/thought-provoking-essay-on-cau.html#comments</comments>
		<pubDate>Wed, 04 Jan 2012 18:23:23 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Post]]></category>
		<category><![CDATA[causation]]></category>
		<category><![CDATA[correlation]]></category>
		<category><![CDATA[criticism]]></category>
		<category><![CDATA[evidence-based medicine]]></category>
		<category><![CDATA[method]]></category>
		<category><![CDATA[mistakes]]></category>
		<category><![CDATA[Science]]></category>

		<guid isPermaLink="false">http://boingboing.net/?p=137266</guid>
		<description><![CDATA[<p>Science is the best method we have for understanding the world. That doesn't mean that everything scientists ever think they've figured out is correct. And it doesn't mean that we're doing science in the best way possible right now.</p>

<p>For a great illustration of this, I recommend reading <a href="http://www.wired.com/magazine/2011/12/ff_causation/all/1">Jonah Lehrer's new piece in WIRED</a>, about the problems we run into as we learn more about individual parts of complex systems and then assume that we understand the big picture of how those parts work together.</p>]]></description>
			<content:encoded><![CDATA[
<p>Science is the best method we have for understanding the world. That doesn't mean that everything scientists ever think they've figured out is correct. And it doesn't mean that we're doing science in the best way possible right now.</p>

<p>For a great illustration of this, I recommend reading <a href="http://www.wired.com/magazine/2011/12/ff_causation/all/1">Jonah Lehrer's new piece in WIRED</a>, about the problems we run into as we learn more about individual parts of complex systems and then assume that we understand the big picture of how those parts work together. A lot of scientific research, particularly in medicine, operates off assumptions like this and it can lead to big mistakes. Case in point: Back pain. In this excerpt, Lehrer explains how MRI technology that allowed doctors to get a better look at the spines of people with back pain led them to make inaccurate conclusions about what was causing the back pain.</p>

<blockquote><p>The lower back is an exquisitely complicated area of the body, full of small bones, ligaments, spinal discs, and minor muscles. Then there’s the spinal cord itself, a thick cable of nerves that can be easily disturbed. There are so many moving parts in the back that doctors had difficulty figuring out what, exactly, was causing a person’s pain. As a result, patients were typically sent home with a prescription for bed rest.</p>

<p>This treatment plan, though simple, was still extremely effective. Even when nothing was done to the lower back, about 90 percent of people with back pain got better within six weeks. The body healed itself, the inflammation subsided, the nerve relaxed.</p>

<p>Over the next few decades, this hands-off approach to back pain remained the standard medical treatment. That all changed, however, with the introduction of magnetic resonance imaging in the late 1970s. These diagnostic machines use powerful magnets to generate stunningly detailed images of the body’s interior. Within a few years, the MRI machine became a crucial diagnostic tool.</p>

<p>The view afforded by MRI led to a new causal story: Back pain was the result of abnormalities in the spinal discs, those supple buffers between the vertebrae. The MRIs certainly supplied bleak evidence: Back pain was strongly correlated with seriously degenerated discs, which were in turn thought to cause inflammation of the local nerves. Consequently, doctors began administering epidurals to quiet the pain, and if it persisted they would surgically remove the damaged disc tissue.</p>

<p>But the vivid images were misleading. It turns out that disc abnormalities are typically not the cause of chronic back pain. The presence of such abnormalities is just as likely to be correlated with the absence of back problems, as a 1994 study published in The New England Journal of Medicine showed. The researchers imaged the spinal regions of 98 people with no back pain. The results were shocking: Two-thirds of normal patients exhibited “serious problems” like bulging or protruding tissue. In 38 percent of these patients, the MRI revealed multiple damaged discs. Nevertheless, none of these people were in pain. The study concluded that, in most cases, “the discovery of a bulge or protrusion on an MRI scan in a patient with low back pain may frequently be coincidental.”</p></blockquote>

<p>This is a complicated problem without a clear solution right now. But we definitely need to have discussions like this so that we can work toward making science and medicine better.</p>

<p>Via Espen in <a href="http://submit.boingboing.net/2012/01/the-reliance-on-correlations-has-entered-an-age-of-diminishing-returns.html">Submitterator</a></p>]]></content:encoded>
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		<item>
		<title>Three common mistakes in medical&#160;journalism</title>
		<link>http://boingboing.net/2011/10/24/three-common-mistakes-in-medical-journalism.html</link>
		<comments>http://boingboing.net/2011/10/24/three-common-mistakes-in-medical-journalism.html#comments</comments>
		<pubDate>Mon, 24 Oct 2011 16:49:11 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Post]]></category>
		<category><![CDATA[DIY]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[Journalism]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[mistakes]]></category>
		<category><![CDATA[Science]]></category>
		<category><![CDATA[skepticism]]></category>

		<guid isPermaLink="false">http://boingboing.net/?p=125596</guid>
		<description><![CDATA[<p>I love Gary Schwitzer, a former journalism professor at the University of Minnesota and a key advocate for <a href="http://www.healthnewsreview.org/blog/">better health and medical reporting at HealthNewsReview.org</a>. Schwitzer has a quick list of the most common mistakes reporters make when writing about medical science, and I think it's something that everybody should take a look at.</p>]]></description>
			<content:encoded><![CDATA[<p>I love Gary Schwitzer, a former journalism professor at the University of Minnesota and a key advocate for <a href="http://www.healthnewsreview.org/blog/">better health and medical reporting at HealthNewsReview.org</a>. Schwitzer has a quick list of the most common mistakes reporters make when writing about medical science, and I think it's something that everybody should take a look at.</p>
<p>Why does this bit of journalism inside-baseball matter to you? Simple. If you know how journalists are most likely to screw up, you'll be less likely to be led astray by those mistakes. And that matters a lot, especially when it comes to health science, where people are likely to make important decisions based partly on what they read in the media.</p>
<p><a href="http://engagingthepatient.com/2011/10/17/how-the-news-media-may-hurt-not-help-health-literacy-efforts/">The three mistakes:</a></p>
<blockquote><p><strong>Absolute versus relative risk/benefit data</strong><br />
<br />Many stories use relative risk reduction or benefit estimates without providing the absolute data. So, in other words, a drug is said to reduce the risk of hip fracture by 50% (relative risk reduction), without ever explaining that it’s a reduction from 2 fractures in 100 untreated women down to 1 fracture in 100 treated women.  Yes, that’s 50%, but in order to understand the true scope of the potential benefit, people need to know that it’s only a 1% absolute risk reduction (and that all the other 99 who didn’t benefit still had to pay and still ran the risk of side effects).</br></p>
<p><strong>Association does not equal causation</strong><br />
<br />A second key observation is that journalists often fail to explain the inherent limitations in observational studies – especially that they can not establish cause and effect.  They can point to a strong statistical association but they can’t prove that A causes B, or that if you do A you’ll be protected from B. But over and over we see news stories suggesting causal links.  They use active verbs in inaccurately suggesting established benefits.</br></p>
<p><strong>How we discuss screening tests</strong><br />
<br />The third recurring problem I see in health news stories involves screening tests. ... “Screening,” I believe, should only be used to refer to looking for problems in people who don’t have signs or symptoms or a family history. So it’s like going into Yankee Stadium filled with 50,000 people about whom you know very little and looking for disease in all of them. ... I have heard women with breast cancer argue, for example, that mammograms saved their lives because they were found to have cancer just as their mothers did. I think that using “screening” in this context distorts the discussion because such a woman was obviously at higher risk because of her family history. She’s not just one of the 50,000 in the general population in the stadium. There were special reasons to look more closely in her. There may not be reasons to look more closely in the 49,999 others.</br></p>
</blockquote>
<p>Via <a href="http://ksjtracker.mit.edu/2011/10/24/gary-schwitzer-three-common-errors-in-medical-reporting/?utm_source=rss&#038;utm_medium=rss&#038;utm_campaign=gary-schwitzer-three-common-errors-in-medical-reporting">The Knight Science Journalism Tracker</a></p>
]]></content:encoded>
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		<title>After (arsenic) life: Great profile of Felisa&#160;Wolfe-Simon</title>
		<link>http://boingboing.net/2011/09/29/after-arsenic-life-great-profile-of-felisa-wolfe-simon.html</link>
		<comments>http://boingboing.net/2011/09/29/after-arsenic-life-great-profile-of-felisa-wolfe-simon.html#comments</comments>
		<pubDate>Thu, 29 Sep 2011 16:34:54 +0000</pubDate>
		<dc:creator>Maggie Koerth-Baker</dc:creator>
				<category><![CDATA[Post]]></category>
		<category><![CDATA[arsenic life]]></category>
		<category><![CDATA[controversy]]></category>
		<category><![CDATA[media]]></category>
		<category><![CDATA[mistakes]]></category>
		<category><![CDATA[mono lake]]></category>
		<category><![CDATA[profile]]></category>
		<category><![CDATA[research]]></category>
		<category><![CDATA[Science]]></category>
		<category><![CDATA[villain]]></category>

		<guid isPermaLink="false">http://boingboing.net/?p=120892</guid>
		<description><![CDATA[<p><a href="http://boingboing.net/2011/09/29/after-arsenic-life-great-profile-of-felisa-wolfe-simon.html/monolake" rel="attachment wp-att-120919"><img src="http://boingboing.net/wp-content/uploads/2011/09/monolake.jpg" alt="" title="monolake" width="640" height="366" class="aligncenter size-full wp-image-120919" /></a></p>

<p>In early 2011, Felisa Wolfe-Simon published a scientific paper purporting to show evidence that bacteria from California's Mono Lake could, if pressed, live without the essential element phosphorous, and use arsenic, instead.</p>

<p>The story was wildly misconstrued in the press. (No, nobody ever found alien life happening naturally in Lake Mono.) And the evidence and methodology of Wolfe-Simon's research was roundly trounced, not just in academic journals, but also in blogs.</p>]]></description>
			<content:encoded><![CDATA[<p><a href="http://boingboing.net/2011/09/29/after-arsenic-life-great-profile-of-felisa-wolfe-simon.html/monolake" rel="attachment wp-att-120919"><img src="http://boingboing.net/wp-content/uploads/2011/09/monolake.jpg" alt="" title="monolake" width="640" height="366" class="aligncenter size-full wp-image-120919" /></a></p>

<p>In early 2011, Felisa Wolfe-Simon published a scientific paper purporting to show evidence that bacteria from California's Mono Lake could, if pressed, live without the essential element phosphorous, and use arsenic, instead.</p>

<p>The story was wildly misconstrued in the press. (No, nobody ever found alien life happening naturally in Lake Mono.) And the evidence and methodology of Wolfe-Simon's research was roundly trounced, not just in academic journals, but also in blogs.</p>

<p>And that's all left Wolfe-Simon in a very weird position. She's certainly not the first scientist to publish a high-profile paper that other researchers tore to shreds. But, because the "arsenic life" story was so high-profile, she's now worried her career might be over. Is that fair? In Popular Science, <a href="http://www.popsci.com/science/article/2011-09/scientist-strange-land">Tom Clynes presents a nuanced profile of Felisa Wolfe-Simon</a> that doesn't really answer that question definitively. Frankly, there probably isn't a really clear black/white answer out there. But Clynes does do a really good job of introducing us to Wolfe-Simon as a person, and her story exposes flaws in the peer-review process and the traditional avenues of scientific debate, indicts the media and PR professionals for creating the very sensational story that led to such a harsh response, and shows what can happen when a scientist is unprepared to deal with the public presentation of their own work.</p>

<p>In other words, this story is about lots of people making mistakes, including, but not limited to, Felisa Wolfe-Simon.</p>

<blockquote><p>
In June, Science reported that Wolfe-Simon had left Oremland’s USGS laboratory to look for a location with better molecular and genetic research facilities. “Actually,” Wolfe-Simon says, “I didn’t leave out of choice. Ron basically evicted me from the group. It was a political decision on his part that I don’t understand, and I didn’t see it coming.” Although she received a NASA fellowship in 2010 that provides support through 2013, she is still seeking a new home for her work.</p>
<p>I find it hard not to feel sympathy for her. In a matter of weeks she was catapulted to fame, then singled out and assaulted with professional and personal criticism, some of which resulted from missteps beyond her control. Wolfe-Simon is an early-career researcher in a field dominated by older men. Few scientists, no matter how established, would have the skills to navigate the situation that she found herself in. What made the level of criticism so extraordinary is that the paper, in itself, is not so flawed that it should not have been published. The argument was compelling, the conclusions were measured, the data was thorough, and the paper made it through the same peer-review process as other articles in Science.</p>

<p>It will take a few years to better answer the questions surrounding GFAJ-1. In the meantime, Benner—who says he would be “more than astonished” if arsenic replaces phosphorus in any genetically relevant molecule in GFAJ-1—says Wolfe-Simon’s hypothesis is ultimately useful if it motivates people to look in new places and ask bigger questions.</p>
<p>Wolfe-Simon says the paper’s publicity attracted new collaborators who she wouldn’t have otherwise met, some of whom are already analyzing GFAJ-1. And her fame has played out in surprising ways. Recently, her husband, Jonathan, an engineer, was speaking with a colleague who asked if he happened to be married to Felisa Wolfe-Simon. When he said yes, the colleague said, “My seven-year-old daughter dressed up as Felisa for her school’s science day!” The girl wore a sun hat, with her pants rolled up and flip-flops on her feet, dressed for a day wading the waters of Mono Lake in search of bacteria.</p></blockquote>

<em><p>Image: <a href="http://www.flickr.com/photos/kidsloveanimals/4128987968/">Mono Lake</a>, a Creative Commons <a href="http://creativecommons.org/licenses/by/2.0/deed.en">Attribution (2.0)</a> image from kidsloveanimals's photostream</p></em>

<div class='contextly_see_also'><span class='contextly_title'></span><div class='contextly_around_site'><div class='contextly_previous'><ul><li><a href='http://boingboing.contextly.com/redirect/?id=rKVm43KaYe'>Meanwhile, scientists are still debating arsenic-based life</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=8XoA9PMi9i'>Weird life found on Earth—kind of, maybe</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=pQz0q70Um0'>Probiotics and "Science by Product Release"</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=F6ure7AIl'>ETs on Earth?</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=ED5iFGDYC8'>Microbiologist turns a skeptical eye on Mono Lake arsenic eaters</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=n6eiWeRL3k'>Meet Science: What is "peer review"?</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=aUasYy0iQa'>Meet Science: What is "peer review"?</a></li><li><a href='http://boingboing.contextly.com/redirect/?id=Sn3cR5viVH'>Science and press conferences: Seeing our own shadow</a></li></ul></div></div></div>
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