Last summer, researchers in Boston announced that they had two patients, men who had battled HIV for years but who now appeared to be virus free. The men had received a treatment similar to that of Timothy Ray Brown, the "Berlin Patient". Like Brown, the men had cancer and had received radiation and chemotherapy treatments followed by bone marrow transplants. But there were some key differences. Brown's radiation and chemo regimes were much harsher, for one thing. For another, his new bone marrow came from a donor with the CCR5-delta32 mutation, which seems to provide natural resistance to HIV infection. The Boston men got their new bone marrow from donors who did not have that mutation.
Nevertheless, both men had seen their viral loads fall to undetectable levels. They hit the news in July after being off of antiretroviral drugs for seven and 15 weeks, respectively, with no return of the virus. Unfortunately, the virus re-emerged in one of the two men the very next month. It re-emerged in the other man in November.
Read the rest