Marilyn sez, "Harvard Medical School researchers have developed an ingenious way to deliver drugs directly to the brain (in order to kill a tumor, for example), that uses the virus that causes rabies, which is extremely effective in infiltrating the blood brain barrier that blocks most other kinds of molecules."
In this study, the drug was injected into the tail of the mice, targeting the blood vessels. Using small interfering RNA (siRNA) as a drug treatment for many diseases has been powerfully successful in other animal models, but the problem has always been the process of making it a practical drug for clinical application. Therefore, this new technology developed by Kumar et al sheds light into a new, non-invasive and feasible way to deliver siRNA specifically to the brain.
siRNA is gaining popularity as a preferred drug treatment method since its early conception in the past seven years. It takes advantage of the cell’s ability to stop its own protein production as soon as a short RNA sequence corresponding to the protein is detected outside of the cell’s nucleus. This triggers a powerful protein synthesis arrest, which can be harnessed to modulate or treat diseases such as diabetes, Hepatitis C, and even transplant rejection.
A few years back, my brother Rick Pescovitz came up with Under The Weather Pods, single-person pop-up shelters. (You may have caught Rick on Shark Tank.) Rick was sick of getting soaked at his kids’ soccer games and was inspired by a portable toilet he saw by the field. Under The Weather Pods are designed […]
Astro Teller is the head of X, the “Moonshot Factory” that first launched as an R&D division of Google. iHeart Radio invited Astro to be part of a fantastic podcast series of virtual commencement speeches for 2020 graduates (and the rest of us) that they collected from the likes of John Legend, Bill & Melinda […]
CeramicSpeed makes bikes that use a drive shaft instead of a chain. Shane Miller got a close look at Eurobike 2018.
Now that the initial furor and shortages have subsided, it’s probably not a bad time to start considering your long-term cleaning and disinfecting plans. Sure, that might seem anywhere from overly cautious to outright ridiculous, but the threat of COVID-19 appears poised to be present for a while and the need for quick travel clean-up […]
With more and more companies moving all their operations into the cloud, the need has never been greater for those with the skills to map exactly how an organization reconstitutes itself in that new environment. Network architects responsible for determining all the communication, storage, and infrastructure needs of an expansive organization are among the most […]
Even after months of working from home, you’d be forgiven for thinking the whole experience still doesn’t quite feel…well, normal. In addition to all the obvious environmental changes of handling your 9 to 5 from your den or dining room table, the technological aids you didn’t realize you loved back at the office probably don’t […]