Bruce Schneier's latest column is a good primer on getting your laptop through US (and other) customs without having your data vacuumed up by the DHS.
Encrypting your entire hard drive, something you should certainly do for security in case your computer is lost or stolen, won't work here. The border agent is likely to start this whole process with a "please type in your password". Of course you can refuse, but the agent can search you further, detain you longer, refuse you entry into the country and otherwise ruin your day.
You're going to have to hide your data. Set a portion of your hard drive to be encrypted with a different key – even if you also encrypt your entire hard drive – and keep your sensitive data there. Lots of programs allow you to do this. I use PGP Disk (from pgp.com). TrueCrypt (truecrypt.org) is also good, and free.
While customs agents might poke around on your laptop, they're unlikely to find the encrypted partition. (You can make the icon invisible, for some added protection.) And if they download the contents of your hard drive to examine later, you won't care.