Ketamine, a tranquilizer/anesthetic and recreational drug, can relieve symptoms of depression for up to a couple of weeks, writes psychiatrist Emily Deans.
In a recent paper, researchers described how they used a noncompetitive inhibitor of the NMDA receptor and partial dopamine receptor agonist, ketamine to rapidly reverse the symptoms of anhedonia in depressed patients. Ketamine has been featured on CBS news for its ability to quickly relieve depression unlike any other pharmacologic agent we have. It is typically used intravenously, and can cause hallucinations and dissociation (in fact it is also known as the club drug “Special K"). However, it seems to be able to reverse damage to the synapses caused by chronic stress, and relieve the symptoms of depression very quickly, within 30-40 minutes.
The down side to ketamine (besides lack of FDA approval for depression, the hallucinations, and lack of general availability) is that the effects don’t last. If you are lucky, you get a couple of weeks, then the depression comes back. Researchers and doctors, however, are hoping ketamine could be used as a bridging agent in seriously depressed, hospitalized patients, allowing them to feel better immediately while other, longer acting but much slower onset agents have a chance to get into the system and do their work. The immediate reversal of the key symptom of anhedonia [inability to experience pleasure] may be an even more important lesson we can learn from the use of ketamine.
The Ketamine Key: The horse tranquilizer helps depressed patients experience pleasure again
EndeavorRx is a first-person racing videogame designed to help children with ADHD and this summer, the FDA approved it as a “prescription treatment.” Meanwhile, other researchers are developing videogames that can help lift depression and reduce anxiety by interrupting the feedback loops of negativity and fear. “It’s a well-known fact that so many mobile games […]
Thanks to the tireless efforts of the non-profit Multidisciplinary Association for Psychedelic Studies (MAPS), the US FDA is clearing the way for ten clinics around the United States to treat PTSD patients with MDMA. It’s likely that the FDA will grant full approval for the therapy in 2020, reports New Atlas. From the article: MAPS […]
For years a friend has been telling my diet was hurting my general demeanor.
If the last 50 years of education have taught us nothing else, it’s that it often requires different tactics to best reach different learners. To pick up a foreign language, some students take best to the old-school high school language lab method, using heavy repetition, verb conjugation and grammar emphasis to embed a new language. […]
For those who want a career in video games, there’s no reason to sit around and wait. EA and Rockstar Games probably aren’t going to seek you out and knock on your door with a job opportunity. But if you’re an indie developer with a good idea and some passion, you can create a really […]
Nobody is happy about the current state of our COVID-ravaged education system. With a new school year fast approaching, plans for teaching students still in flux, and political in-fighting driving more fear and confusion about whether or not to re-open campuses, teachers and parents are concerned. Meanwhile, most kids are just fine with spending less […]