In 1943 Sandoz chemist Albert Hofmann became the first person to synthesize (and take) LSD. He was also the first person to isolate and identify psilocybin, the main psychedelic component in magic mushrooms, almost 60 years ago. "Yet no one has been able to unravel the enzymatic pathway the mushrooms use to make psilocybin, until now," reports Stephen K. Ritter of Chemical and Engineering News.
Janis Fricke, Felix Blei, and Dirk Hoffmeister of Friedrich Schiller University Jena have identified and characterized to the greatest extent so far the four enzymes that the mushrooms use to make psilocybin. The team then developed the first enzymatic synthesis of the compound, setting the stage for its possible commercial production (Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201705489).
Image: Erik Fenderson/Wikipedia
Based on a new study of the safety and abuse potential of psilocybin, the hallucinogenic drug in magic mushrooms, Johns Hopkins University School of Medicine researchers recommend that “psilocybin should be re-categorized from a schedule I drug—one with no known medical potential—to a schedule IV drug such as prescription sleep aids, but with tighter control.”
Pioneering engineer Bill Atkinson was the lead designer/developer of the Apple Lisa graphical user interface, creator of MacPaint and QuickDraw, and part of the original team that developed the Apple Macintosh. In 1985, Atkinson dropped acid and came up with HyperCard, the groundbreaking multimedia authoring program that was really a precursor to the first Web […]
Neuroscience researcher Roland Griffiths at the Johns Hopkins University School of Medicine is leading a scientific study on “the experiences of people who have had encounters with seemingly autonomous beings or entities after taking DMT.” If that’s you, fill out the anonymous survey! Just say know. From the Daily Grail: Dr. Roland R. Griffiths is […]
Just a reminder: Print isn’t dead. And now that printers are becoming as portable as cell phones, it might be around for quite some time. Enter the MEMOBIRD Mobile Thermal Printer, a mini-printer that is versatile, portable – and most importantly, never needs a refill on ink or toner. Measuring just a few inches around, […]
What do Facebook, Twitter, YouTube and Google all have in common? Somewhere in their framework, they all use MySQL, that most versatile (and free!) of database management systems. And they’re not alone. If your company or the one you’d like to work for wrangles data (and who doesn’t?), they’re going to need someone with a […]
There’s a reason you’re hearing about the gig economy in every other business story these days. More than ever, people are finding income from more than one source. And if you find the right one, a side hustle can do more than just pad your pockets – it can allow you to finally get paid […]