In 1943 Sandoz chemist Albert Hofmann became the first person to synthesize (and take) LSD. He was also the first person to isolate and identify psilocybin, the main psychedelic component in magic mushrooms, almost 60 years ago. "Yet no one has been able to unravel the enzymatic pathway the mushrooms use to make psilocybin, until now," reports Stephen K. Ritter of Chemical and Engineering News.
Janis Fricke, Felix Blei, and Dirk Hoffmeister of Friedrich Schiller University Jena have identified and characterized to the greatest extent so far the four enzymes that the mushrooms use to make psilocybin. The team then developed the first enzymatic synthesis of the compound, setting the stage for its possible commercial production (Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201705489).
Finally, researchers are again exploring the therapeutic benefits of psychedelics to treat the likes of depression, addiction, and obsessive-compulsive disorder. To provide pharmaceutical-quality compounds for clinical trials, scientists are developing new ways to produce the psychedelics. Chemical engineers at Miami University in Ohio have now genetically engineered E. coli to crank put psilocybin, the psychoactive […]
Ram Dass — counterculture icon, psychedelic pioneer, and spiritual guide — has died at age 88. After turning on with his Harvard psychology colleague Timothy Leary in the early 1960s, Ram Dass (formerly Richard Alpert) became an intrepid explorer of higher consciousness and dedicated his life to teaching what he learned to the world. From […]
One fantastic and wonderful origin theory of Santa Claus involves psychedelic mushrooms and shamanic rituals of the indigenous Sámi people who live in northern Finland. Paul Devereux wrote about this incredible hidden history in his fascinating 2008 book The Long Trip: A Prehistory of Psychedelia. Then, Brooklyn filmmaker Matthew Salton blew mainstream minds with this […]
The latest iPhone cameras are undeniably impressive, but they’re still no match for a professional camera when it comes to taking clear, wide-angle shots. These six accessories will transform your iPhone into a pro-level camera in seconds, thanks to powerful and easy-to-attach lenses. 1. Lemuro 18MM iPhone Wide Lens MSRP: $100 | Sale Price: $80 […]
Few things in life are more universally dreaded than going to the gym, which is unfortunate since a new year usually means making new resolutions to get in shape. Thankfully, this BodyBoss 2.0: Portable Home Gym has everything you need to burn fat and build muscle in the comfort of your own home. With just […]
If one of your New Year’s resolutions is to travel more, you owe it to yourself to learn the language of the place you’re visiting. If you’re not sure where to start, give these resources a look. From mobile apps to online courses, these products can get you conversant in a new language before you […]