In 1943 Sandoz chemist Albert Hofmann became the first person to synthesize (and take) LSD. He was also the first person to isolate and identify psilocybin, the main psychedelic component in magic mushrooms, almost 60 years ago. "Yet no one has been able to unravel the enzymatic pathway the mushrooms use to make psilocybin, until now," reports Stephen K. Ritter of Chemical and Engineering News.
Janis Fricke, Felix Blei, and Dirk Hoffmeister of Friedrich Schiller University Jena have identified and characterized to the greatest extent so far the four enzymes that the mushrooms use to make psilocybin. The team then developed the first enzymatic synthesis of the compound, setting the stage for its possible commercial production (Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201705489).
Image: Erik Fenderson/Wikipedia
Based on a new study of the safety and abuse potential of psilocybin, the hallucinogenic drug in magic mushrooms, Johns Hopkins University School of Medicine researchers recommend that “psilocybin should be re-categorized from a schedule I drug—one with no known medical potential—to a schedule IV drug such as prescription sleep aids, but with tighter control.”
Pioneering engineer Bill Atkinson was the lead designer/developer of the Apple Lisa graphical user interface, creator of MacPaint and QuickDraw, and part of the original team that developed the Apple Macintosh. In 1985, Atkinson dropped acid and came up with HyperCard, the groundbreaking multimedia authoring program that was really a precursor to the first Web […]
Neuroscience researcher Roland Griffiths at the Johns Hopkins University School of Medicine is leading a scientific study on “the experiences of people who have had encounters with seemingly autonomous beings or entities after taking DMT.” If that’s you, fill out the anonymous survey! Just say know. From the Daily Grail: Dr. Roland R. Griffiths is […]
Anyone can learn piano, but don’t tell that to the bored kids who had to endure hours of “Chopsticks” and similar drills in their music lessons. Today, there’s a better way. Pianoforall lets you jump right in to discover what makes music fun, leaving you eager to learn more. In a simple but innovative approach, […]
There are two times you never want to just “eyeball” it: Conducting brain surgery and matching shades of paint for your walls. Whether you’re painting or repainting, make sure you’re never just “close enough” to the color you want. Not when the Nix Mini Color Sensor can scan and match any color perfectly. Small enough […]
In photography as in film, all the real artistry is in post-production – increasingly so, with the new possibilities cropping up in digital imaging. If you’re ready to get serious about your photography, may we suggest HDR Projects 2018 Pro. As working photographers can tell you, this imaging software can help you re-imagine even the […]