In 1943 Sandoz chemist Albert Hofmann became the first person to synthesize (and take) LSD. He was also the first person to isolate and identify psilocybin, the main psychedelic component in magic mushrooms, almost 60 years ago. "Yet no one has been able to unravel the enzymatic pathway the mushrooms use to make psilocybin, until now," reports Stephen K. Ritter of Chemical and Engineering News.
Janis Fricke, Felix Blei, and Dirk Hoffmeister of Friedrich Schiller University Jena have identified and characterized to the greatest extent so far the four enzymes that the mushrooms use to make psilocybin. The team then developed the first enzymatic synthesis of the compound, setting the stage for its possible commercial production (Angew. Chem. Int. Ed. 2017, DOI: 10.1002/anie.201705489).
Image: Erik Fenderson/Wikipedia
Neuroscience researcher Roland Griffiths at the Johns Hopkins University School of Medicine is leading a scientific study on “the experiences of people who have had encounters with seemingly autonomous beings or entities after taking DMT.” If that’s you, fill out the anonymous survey! Just say know. From the Daily Grail: Dr. Roland R. Griffiths is […]
Terence McKenna (1946-2000) was an ethnobotanist, psychedelic pioneer, philosopher, and shamanic scholar who boldly explored the mysteries of consciousness and the fringes of reason with rigor, wit, and generosity. Now, Kevin Whitesides with support of fellow travelers like BB pal Erik Davis are working hard “to collect, digitize, transcribe, store, and preserve the imprint of […]
A friend and I were talking last night about ego dissolution (something we’ve both experienced). I was telling him about this recent Vox article that shares the author’s first-hand account of an ayahuasca trip at Rythmia, a luxury “life advancement” resort in Costa Rica. What really struck me about his tale is how he describes […]
Businesses big and small use Microsoft Excel for everything from data visualization to bookkeeping, and chances are you’ve already had some exposure to this ubiquitous tool. Whether you’re looking to improve your hiring potential or boost your Excel efficiency, the Ultimate All-Level Excel Bootcamp can get you Excel-savvy with nearly 70 hours of training, and it’s […]
The workday is long, and inevitably, you’re going to find yourself needing to take a break from the daily grind. With Mini Materials Miniature Cinder Blocks, you can take some time for yourself and decompress by turning your desk into a miniature construction site. They’re available today in the Boing Boing Store for $22.49. Handmade […]
Handheld radios might seem a bit archaic, but in an emergency situation, few things will keep you as reliably connected to the outside world. This Emergency Multi-Function Radio & Flashlight takes the utility of the tried-and-true radio and combines it with a powerful flashlight and self-sufficient energy system. It’s available in the Boing Boing Store for […]