Researchers demonstrated single-molecule nanomachines that can target diseased cells and then kill them by drilling through the cell membrane. Developed by a team at Rice University, Durham University (UK), and North Carolina State University, the single-molecule nanomotors are about one-billionth of a meter wide and spin at 2 to 3 million rotations per second. They're activated by ultraviolet light and could also be used to deliver drug treatment into the cells. From Rice:
“These nanomachines are so small that we could park 50,000 of them across the diameter of a human hair, yet they have the targeting and actuating components combined in that diminutive package to make molecular machines a reality for treating disease,” Tour said...
The researchers found it takes at least a minute for a motor to tunnel through a membrane. “It is highly unlikely that a cell could develop a resistance to molecular mechanical action,” Tour said.
Pal expects nanomachines will help target cancers like breast tumors and melanomas that resist existing chemotherapy. “Once developed, this approach could provide a potential step change in noninvasive cancer treatment and greatly improve survival rates and patient welfare globally,” he said...
The Pal lab at Durham tested motors on live cells, including human prostate cancer cells. Experiments showed that without an ultraviolet trigger, motors could locate specific cells of interest but stayed on the targeted cells’ surface and were unable to drill into the cells. When triggered, however, the motors rapidly drilled through the membranes.
"Molecular machines open cell membranes" (Nature)
Repeating the word “fuck” actually can reduce your experience of pain, according to a new study by Keele University researchers. The psychologists ran an experiment in which subjects underwent a cold pressor test, a common method to pain threshold and tolerance by immersing your hand in freezing cold water for a minute. (See above video […]
Floating out of your body and looking down on it. The story of your life flashing by before your eyes. Seeing a bright light at the end of a dark tunnel. These are just two of the most common experiences that people report after a near-death experience (NDE). For some people, NDEs are a transformative […]
I enjoy the fun science stunts on ScienceBob’s YouTube Channel.
First, they were all about serving a protective necessary function. But now, about 10 weeks after the explosion of the COVID-19 outbreak, face masks are beginning to serve a different role. Just like all the fashion accessories that came before them, face masks are now showing off a little piece of ourselves to the everyday […]
Promoting products is almost nothing like it was back in the Mad Men days. In fact, the digital landscape has changed the ad game so much that it barely even resembles early Grey’s Anatomy days anymore. Marketing a product digitally isn’t about the right ad slogan or color scheme. It’s about crafting the narrative around […]
Every once in a while, we see a new product come along that’s so versatile and elegantly simple that it’s strange no one’s ever gone there before. Portable lights themselves aren’t new, but there’s something about the MOGICS Coconut Light that’s so seamlessly well-designed and adaptable that it feels startlingly original. The Coconut is basically […]