From Million Dollar Baby to Requiem for a Dream: the most depressing mainstream films

"What is the most depressing mainstream movie?" asks a redditor on r/askreddit. The answers include movies about human suffering, loss, societal issues, and the hopeless situations faced by their characters.

Million Dollar Baby – Soul-crushing story of a boxer's tragic fate.

Grave of the Fireflies – Heartbreaking tale of orphaned children during World War II.

The Deer Hunter – Devastating portrayal of the Vietnam War's impact on soldiers.

Bridge to Terabithia – Unexpected loss of a young friend causes deep grief.

The Wrestler – Depressing portrayal of a washed-up wrestler's struggles.

Manchester by the Sea – Deals with overwhelming grief and guilt.

The Road – Post-apocalyptic survival story with constant bleakness.

Schindler's List – Brutal depiction of the Holocaust.

Requiem for a Dream – Tragic downward spiral of drug addiction.

Marley & Me – Emotional journey of a family's beloved dog, ending in loss.

A.I. Artificial Intelligence – Exploration of loneliness and the search for love.

Threads – Terrifying and bleak portrayal of nuclear war aftermath.

Dancer in the Dark – Tragic story of a woman facing numerous hardships.

Leaving Las Vegas – Depiction of alcoholism and self-destruction.

Boys Don't Cry – true story of transgender man's tragic fate.

I don't think anyone mentioned A Serbian Film (which I didn't see and won't see) and Speak No Evil (which I did see, and I'm sorry that I saw), but that could be because they aren't really main stream. These movies could also be considered more disturbing than depressing, but there's enough overlap between those two ideas that I would add them to the list above.

Previously:
Why Google's CAPTCHA images are 'so unbearably depressing'
Red Dead Redemption 2 is depressing as all get out
Mind-bogglingly depressing women's magazine from 1966
Theme from Friends as a depressing, minor-key ballad