Brain-zapping implants that change mood and lift depression

Teams of researchers are developing sesame seed-size neuro-implants that detect brain activity that signals depression and then deliver targeted electrical zaps to elevate your mood. It's very early days in the science and technology but recent studies suggest that we're on the path. Links to scientific papers below. Fortunately, the goal is to develop tools and a methodology more precise than the horrifically blunt "shock therapy" of last century. From Science News:

DARPA, a Department of Defense research agency, is funding (Massachusetts General Hospital's research on new brain stimulation methods) plus work at UCLA on targeted brain stimulation. Now in its fifth and final year, the (DARPA) project, called SUBNETS, aims to help veterans with major depression, post-traumatic stress, anxiety and other psychiatric problems. “It is extremely frustrating for patients to not know why they feel the way they do and to not be able to correct it,” Justin Sanchez, the director of DARPA’s Biological Technologies Office, said in a Nov. 30 statement. “We owe them and their families better options.”

These next-generation systems, primarily being developed at UCSF and Massachusetts General Hospital, might ultimately deliver. After detecting altered brain activity that signals a looming problem, these devices, called closed-loop stimulators, would intervene electrically with what their inventors hope is surgical precision.

In contrast to the UCSF group, Widge, who is at the University of Minnesota in Minneapolis, and his collaborators don’t focus explicitly on mood. The researchers want to avoid categorical diagnoses such as depression, which they argue can be imprecise.

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