The Hedonistic Imperative, a post-human, post-suffering manifesto:
The metabolic pathways of pain and malaise evolved because they served the fitness of our genes in the ancestral environment. They will be replaced by a different sort of neural architecture. States of sublime well-being are destined to become the genetically pre-programmed norm of mental health. The world's last unpleasant experience will be a precisely dateable event.
(via The Schism Matrix)