Princeton's David Tank just published a paper in Nature describing how he used the open-source Quake 2 engine to power a VR maze that he ran mice through in order to study their neurons while they moved. My wife, who played Quake on the British national team, wants to teach the mouse to rocket-jump.
Tank's team designed an apparatus in which a mouse, its head firmly held in a metal helmet, walks on the surface of a styrofoam ball. The ball is kept aloft by a jet of air, so that it functions like a multidirectional treadmill. Around it are sensors taken from optical computer mice, which read the ball's movement as the mouse runs.
Those readings were the input for the researchers' virtual reality software -- a modified version of the open source Quake 2 videogame engine, tweaked to project an image on a screen surrounding the mouse. Tank called it "a mini-IMAX theater."
Mice in the study ran through a virtual maze designed in the open source Quake game editor, but rather than earning points or power-ups, they were rewarded with sips of water from a head-side nozzle.
Into the hippocampus of each mouse the researchers inserted a glass capillary just one micron wide at its tip and filled with salt water. Known as a whole-cell patch recorder, it detects electrical currents as they pulse through individual cells.
"It is difficult to overstate the importance of understanding how the dynamics of electrical activity within single neurons is related to firing patterns among collections of neurons that accompany the performance of complex tasks," wrote Douglas Nitz, a University of California at San Diego cognitive scientist, in a commentary accompanying the findings.
Researchers successfully revived ancient microbes, some more than 100 million years old, that were buried in the seafloor. During an expedition to the South Pacific Gyre, the scientists from the Japan Agency for Marine-Earth Science and Technology (JAMSTEC) and their colleagues drilled into the ocean sediment almost 6,000 meters below the surface. “Our main question […]
My family stopped wiping down all our groceries to “disinfect” them a couple months ago, mostly because of hygiene exhaustion. Then in May, the Center for Disease Control and Prevention clarified its own Web page about how COVID-19 spreads to state that “based on data from lab studies on COVID-19 and what we know about […]
Creating a fantasy world for a video or role-playing game is tough enough. In addition to all the game framework and functionality that goes into a build of any size, creators invariably sweat over the most minute details of every weapon, outfit, or other distinctive objects in their game. Even if your game is set […]
We get it. You don’t have to go to the office anymore. That’s no excuse for letting your grooming go positively feral. We’re not saying you need to be GQ cover model-ready every Monday through Friday. But at least put in some effort to keep yourself relatively trimmed, clean, and on point. Even if you […]
With everybody cooped up inside right now, it’s no surprise that many houses are starting to get a little bit…well, funky. Yeah…they smell. With everybody running around and sweating and working and cooking and everything else, odors get trapped inside your home. And don’t even get us started on what happens when litter boxes and […]