Manhattan's aptly named Mondohub is a 28-port USB hub (24 USB 2.0, 4 USB 3.0). The last time I set up a new desk, I went hunting for some $BIGNUM-port hubs and they all seemed to cap out at 10 or 12. As a result, I've got a ton of daisy-chained, impossible-to-debug USB hubs on my desk, running the external HDDs, the cameras and mics, printer/scanner, chargers for various devices, keyboards, pointers, etc. This would make a big difference, though I'd be happy with a 100-port version, too.
(via Red Ferret)