We've talked here before about the importance of the protein CCR5 in HIV/AIDS treatment research. CCR5 is a protein on the surface of immune cells. Some people have a genetic mutation, called Delta-32, which alters how that protein works, how often it appears, or changes its structure. People with the mutation have immunity to some strains of HIV, the virus that causes AIDS.
CCR5 is the key to the Berlin Patient—Timothy Ray Brown—who, until recently, was the only person to ever be cured of AIDS. Brown received bone marrow transplants from people who had the Delta-32 mutation. His body has been HIV-free for five years. And, last week, researchers announced that two other people successfully received the same treatment.
But here's the thing, until today, I didn't totally understand how the connection between CCR5, Delta-32, and HIV worked. There's a story (and some great digital illustrations) on NPR's Shots blog that makes the situation much more clear. HIV, apparently, have little spikes all over its surface. These spikes are how the virus injects itself into cells.
When it bumps into a T cell, a finger-like projection on the cell's surface, called CCR5, pushes down on the spike. This interaction pops open the HIV and releases the infectious genes into the cell. A gene therapy could protect T cells by inactivating the CCR5 gene.
Great "A-ha!" moment for me. Read the rest of the story and look at the illustrations. It'll make some thing make a lot more sense.
Read the rest at NPR's Shots blog
If AIDS Has Been Cured, Why is the Victory Party So Small?
AIDS Research Done by 17-Year-Olds
Joe Karganis writes, "This is the 'Co-Assignment Galaxy' created by David McClure. It maps the top 160K titles in the new Open Syllabus 2.0 dataset, based on the frequency with which those texts are assigned (reflected in the size of the dot) and assigned together (reflected in the location and clustering of the dots). It's […]
The Bank of England has unveiled its new £50 notes, which had been earmarked to honour a distinguished British scientist, and which will feature Alan Turing, the WWII hero who discovered many of the foundational insights to both modern computing and cryptography, and whose work with the codebreakers of Bletchley Park are widely believed to […]
The great science purge, they’ll call it one day. Donald Trump is closing science offices throughout the federal government. ‘As of June, around 85 percent of all scientific posts in the federal government, including an official scientific advisor to the President, were left unfilled,’ write the editors of I F***ing Love Science blog in an […]
Vape technology has been around long enough that vapers are starting to get picky about their gear. Luckily, so are we. From disposable models to cutting-edge touchscreen atomizers, there’s a vaporizer in this roundup to suit every taste. Hera 2 – World’s Most Advanced Dual-Use Vaporizer Choose between dry herb or oil extraction modes – […]
With enough practice and commitment, anyone can be a visual artist. But without the right instruction, that time spent honing your skills could seem like an eternity. If you really want to see where your talent can take you, you need sound fundamentals – and no matter what discipline or genre you lean toward, the […]
Theoretically, there’s never been an easier time for marketers. The ubiquity of social media means a good word – or a good brand – can spread like wildfire with very little effort. But as limitless as the internet is, there’s a lot of competition and noise to contend with. And the vast graveyard of failed […]