Microfluidic systems that move and mix tiny amounts of liquids are used in laboratories for biotechnology, chemistry, and even the development of inkjet technology. Frequently, microfluidic devices are integrated into a single "lab on a chip" but fabricating such systems can be costly and time-consuming. Now, MIT researchers are using customized LEGO bricks to make a modular microfluidics platform. Their prototype system "could be used to manipulate biological fluids and perform tasks such as sorting cells, filtering fluids, and encapsulating molecules in individual droplets." From MIT:
To demonstrate modularity, (mechanical engineering grad student Crystal) Owens built a prototype onto a standard LEGO baseplate consisting of several bricks, each designed to perform a different operation as fluid is pumped through. In addition to making the fluid mixer and droplet generator, she also outfitted a LEGO brick with a light sensor, precisely positioning the sensor to measure light as fluid passed through a channel at the same location.
Owens says the hardest part of the project was figuring out how to connect the bricks together, without fluid leaking out. While LEGO bricks are designed to snap securely in place, there is nevertheless a small gap between bricks, measuring between 100 and 500 microns. To seal this gap, Owens fabricated a small O-ring around each inlet and outlet in a brick.
“The O-ring fits into a small circle milled into the brick surface. It’s designed to stick out a certain amount, so when another brick is placed beside it, it compresses and creates a reliable fluid seal between the bricks. This works simply by placing one brick next to another,” Owens says. “My goal was to make it straightforward to use.”
I can’t believe I have to write this, but maybe jamming other people’s shit up your ass isn’t a great idea. When done by medical professions, under very specific circumstances, a fecal transplant can mean the difference between life and death: implanting feces containing healthy gut microbiome into a patient’s body has been used by […]
Good news! This week, folks living in as far north as Michigan may get treated to a stunning light show as Auroras will be shining brighter and further away from the planet’s axis than usual. What a rare treat! The bad news: the same phenomenon that causes the Northern Lights to do their thing could […]
In 1990, once NASA’s twin Voyager probes had completed their grand tour of the solar system, it came time to shut off their cameras to preserve power and memory for the other scientific instruments onboard. But before that happened, there was one last photo opportunity not to be missed. Carl Sagan, a member of the […]
Trains may not be the most popular means of conveyance nowadays, but chances are you grew up playing with toy trains or building a model set to wrap around the Christmas tree. In either case, it’s safe to say that locomotives have long carried a unique sense of awe and scale, especially when they’re hundreds […]
When it comes to redesigning or renovating a living space, envisioning changes before they occur can be tricky for most. Thankfully, the web is home to tools that can remove some of the guesswork, like Live Home 3D Pro for Mac. This app lets you create detailed and furnished floor plans for everything from sheds and […]
For many startups and fledgling businesses, web hosting — and the fees associated with it — can take a sizeable chunk out of the company budget and limit growth down the road. But, that’s not to say there aren’t hosts out there who can get your site online while staying within your budget. Arch Hosting is a […]