Microfluidic systems that move and mix tiny amounts of liquids are used in laboratories for biotechnology, chemistry, and even the development of inkjet technology. Frequently, microfluidic devices are integrated into a single "lab on a chip" but fabricating such systems can be costly and time-consuming. Now, MIT researchers are using customized LEGO bricks to make a modular microfluidics platform. Their prototype system "could be used to manipulate biological fluids and perform tasks such as sorting cells, filtering fluids, and encapsulating molecules in individual droplets." From MIT:
To demonstrate modularity, (mechanical engineering grad student Crystal) Owens built a prototype onto a standard LEGO baseplate consisting of several bricks, each designed to perform a different operation as fluid is pumped through. In addition to making the fluid mixer and droplet generator, she also outfitted a LEGO brick with a light sensor, precisely positioning the sensor to measure light as fluid passed through a channel at the same location.
Owens says the hardest part of the project was figuring out how to connect the bricks together, without fluid leaking out. While LEGO bricks are designed to snap securely in place, there is nevertheless a small gap between bricks, measuring between 100 and 500 microns. To seal this gap, Owens fabricated a small O-ring around each inlet and outlet in a brick.
“The O-ring fits into a small circle milled into the brick surface. It’s designed to stick out a certain amount, so when another brick is placed beside it, it compresses and creates a reliable fluid seal between the bricks. This works simply by placing one brick next to another,” Owens says. “My goal was to make it straightforward to use.”
In the early 20th century, Arthur Earland and Edward Heron-Allen volunteered at what’s now called the Natural History Museum, London (NHM). The two men spent their time researching fossils of single-celled organisms with shells, called Foraminifera, cataloging the various species, and creating microscope slides of the specimens. But each year when Christmas came around, they […]
Michael Nielsen was a Fulbright Scholar who got his Ph.D. in Physics at 24. He was already tenured when he decided just three years later to shift his attention to helping democratize Science. He’s published three books, most recently Reinventing Discovery: The New Era of Networked Science. Currently, he’s a Research Fellow at YC Research […]
In the year 2,000, Susan Potter, then 72, donated her body to medicine. After Potter died, scientists froze her corpse, sliced it into 27,000 slivers thinner than a human hair, photographed each slice, and created “the world’s most advanced virtual cadaver using the highest-quality imagery of an entire human body in existence.” Not only is […]
For the true audio enthusiast, there’s a lot of difference between putting on some songs “for background music” and a true listening experience. For the latter, there’s nothing like a pair of sturdy headphones and the powerful speakers that come with them. And the wireless variety doesn’t get much more powerful than the TREBLAB Z2 […]
Digital or analog, there’s a path of least resistance for any project. Finding that path is what the Agile methodology is all about, which is why proficiency in it is a must for any project management position – and the paycheck that comes with it. And the quickest path to learning Agile? The Agile Project […]
Everybody’s flown a paper airplane. But what if you could fly on a paper airplane? Until we invent shrink-ray technology, the PowerUp X FPV Video Paper Airplane Kit will have to do – but it’s as fun as that sounds and more. The original version of this creative toy added drone tech to the old, […]