Finally, researchers are again exploring the therapeutic benefits of psychedelics to treat the likes of depression, addiction, and obsessive-compulsive disorder. To provide pharmaceutical-quality compounds for clinical trials, scientists are developing new ways to produce the psychedelics. Chemical engineers at Miami University in Ohio have now genetically engineered E. coli to crank put psilocybin, the psychoactive ingredient in magic mushrooms. From Scientific American:
The modified microbes generated up to 1.16 grams of psilocybin per liter of culture medium—the highest yield to date from any engineered organism and a 10-fold increase over the next best attempt. Scaled up, the new method could produce psilocybin for potential therapeutic use.
“The number-one advantage is it's simply cheaper” than—or at least cost-competitive with—other methods, says lead study author Alexandra Adams, an undergraduate student in chemical engineering at Miami University in Ohio...
Adams and her colleagues engineered E. coli that incorporated three genes from the Psilocybe cubensis mushroom, enabling the bacteria to synthesize psilocybin from the cheap and easily obtainable precursor molecule 4-hydroxyindole, and then they optimized the process to produce the drug on a larger scale.
Police in Salerno, Italy made the largest drug seizure in history: 15.4 tons of amphetamines valued at US$1.12 billion. The Guardia di Finanza say that the pills—found inside three shipping containers at the port—were produced by ISIS in Syria. Scanners didn’t detect the haul but police knew to expect them. From CNN: “We weren’t able […]
On June 12th, 1970, Dock Ellis pitched a no-hitter for the Pittsburgh Pirates against the San Diego Padres while he was high out of his god damn gourd on LSD. As he told the Ottawa Citizen: I can only remember bits and pieces of the game. I was psyched. I had a feeling of euphoria. […]
Spanish police arrested Nacho Vidal — a porn star with a side hustle making penis candles — for suspected manslaughter following a “mystic ritual” in which participants smoked the psychedelic venom of the Colorado River Toad. According to Vidal’s attorney Daniel Salvador, the fellow who died, photographer Jose Luis Abad, had “previously tried that substance […]
“I probably use my chef’s knives more than any other tool in the kitchen.” – Bobby Flay, celebrity chef Cooking at home has taken on a whole new life in the wake of COVID-19, and even with restaurants slowly reopening across the US, there’s heavy reason to suspect that more of us preparing more meals […]
More than half of you think the best way to manage your passwords is to just keep ‘em safely stashed away in your own noggin. Meanwhile, there are also bunches of you that favor saving passwords in your browser, putting them in a spreadsheet or just writing them down on a piece of paper or […]
With all the website builders on the market, it can feel overwhelming to choose the best one for your needs. The most important things to look for are usability, flexibility and a professional look and feel. That’s why over 180 million people use Wix to create the website of their dreams. Here are the top […]