Finally, researchers are again exploring the therapeutic benefits of psychedelics to treat the likes of depression, addiction, and obsessive-compulsive disorder. To provide pharmaceutical-quality compounds for clinical trials, scientists are developing new ways to produce the psychedelics. Chemical engineers at Miami University in Ohio have now genetically engineered E. coli to crank put psilocybin, the psychoactive ingredient in magic mushrooms. From Scientific American:
The modified microbes generated up to 1.16 grams of psilocybin per liter of culture medium—the highest yield to date from any engineered organism and a 10-fold increase over the next best attempt. Scaled up, the new method could produce psilocybin for potential therapeutic use.
“The number-one advantage is it's simply cheaper” than—or at least cost-competitive with—other methods, says lead study author Alexandra Adams, an undergraduate student in chemical engineering at Miami University in Ohio...
Adams and her colleagues engineered E. coli that incorporated three genes from the Psilocybe cubensis mushroom, enabling the bacteria to synthesize psilocybin from the cheap and easily obtainable precursor molecule 4-hydroxyindole, and then they optimized the process to produce the drug on a larger scale.
Karl Rock, a YouTuber who posts tourist tips for travelers to India, uses a hidden camera to film people running recreational drug operations in their restaurants. Rock says: For some reason, drug dealers think I look like a drug user, so I often get approached in India and asked if I want to buy drugs. […]
Please enjoy the underground classic “Rabbit Habit” by Steve Peck, who writes: This is an animated cartoon I produced myself in 1975 to show what Bugs, Daffy and Elmer would be doing in Central Park 12 years after WB stopped making Looney Tunes…..I showed it to Tex Avery in 1975 when he was 80 and […]
In Ashland, Louisiana, a woman has been arrested on drug charges when police decided the $5,000 cash she used to post an inmate’s bail carried the “strong odor of marijuana.” The Terrebonne Parish Sheriff’s Office started nosing around Stormy Lynn Parfait, 33, last Friday after she showed up to pay bond for an inmate jailed […]
If you’re routinely prone to being stressed out, hurried or generally made out-of-sorts by the hectic pace of the world and life changes, then…yikes. We don’t envy what you must be going through these days. Right about now, even the most zen and centered among us are bound to be feeling some level of anxiety […]
So…exactly how many times a day are you singing Happy Birthday to your sink? Unless you’re among the most germaphobic among us, it’s unlikely you ever thought the simple act of handwashing would start to take on such a central role in our daily lives. Of course, with all the touching and such, bar soap […]
Paralysis by analysis. It’s the phenomenon that happens when you’re so stuck on thinking through all the ramifications of your actions that you don’t actually take action in the first place. That can happen with all this free time you’re spending stuck inside your house. With literally every home-bound option available to you, it’s easy […]