People who suffer from chronic itching say it's more unbearable than pain. I'll never forget a 2008 story called The Itch in The New Yorker. It's about a woman whose scalped itched so much that "She had scratched through her skull during the night—and all the way into her brain."
Chemical and Engineering News reports that a compound in the popular psychedelic plant Salvia divinorum was found to contain a compound that is found to provide itch relief to mice.
Salvinorin A, a hallucinogen produced by the Mexican plant Salvia divinorum, holds promise for treating itch and pain because it activates the κ-opioid receptor while avoiding the μ-opioid receptor, a sister receptor that’s been associated with opioid abuse. Chemists have tried to synthesize salvinorin A so that they could alter the structure to sidestep the compound’s psychoactive effects while preserving its analgesic properties. But salvinorin A’s scaffold has been challenging to recreate.
Now, a team of scientists at the California and Florida branches of Scripps Research Institute, as well as at the University of Southern California, report a 10-step total synthesis of 20-norsalvinorin A (ChemRxiv 2017, DOI: 10.26434/chemrxiv.5318188). The compound differs from salvinorin A by a single methyl group and binds to the κ -opioid receptor with an affinity similar to that of the natural product. When given to mice, it also provides itch relief.
At Chemistry Blog, Nick Uhlig explores the chemistry of William Gibson’s classic novel Neuromancer. Apart from inventing the term “cyberspace” and predicting virtual reality long before it became commonplace, Neuromancer also contains some interesting tidbits of chemistry. Being a chemist myself, specifically one in the pharma industry, these little nuggets of scientific prose jump out […]
YouTuber NileRed was curious about how lactose-free milk is made, so he did a little research and came up with this helpful explainer.
I found out about Shit Ghost from this Reddit thread: “My seemingly normal project manager abruptly quit his nice paying job a couple years ago for unknown reasons. I facebooked him today out of curiosity to discover he is now dresses up in costume as a character he calls “Shit Ghost” and makes really obscure […]
The human eye is a powerful thing, but it’s not so great at seeing in the dark or around tight spaces, which is partially why most of us struggle with unplugging drains, cleaning under the fridge, and other hard-to-reach jobs. This 1080p HD Waterproof WiFi Wireless Endoscopic Camera, however, gives you the flexibility necessary to get […]
Macs are undeniably some of the most versatile computers on the market, but they can do so much more than what their stock apps allow. For those looking to get the most out of their Mac hardware, the Pay What You Want 2018 Super Mac Bundle features 10 of the industry’s top apps, including photo editors and […]
Salesforce has reinvented the way companies manage customer information, close deals, and ultimately drive revenue, so it should come as no surprise that it’s one of the more valuable skills you can list on your resume today. In fact, according to research from Burning Glass, this platform is now the 7th most in-demand software skill, beating out […]