People who suffer from chronic itching say it's more unbearable than pain. I'll never forget a 2008 story called The Itch in The New Yorker. It's about a woman whose scalped itched so much that "She had scratched through her skull during the night—and all the way into her brain."
Chemical and Engineering News reports that a compound in the popular psychedelic plant Salvia divinorum was found to contain a compound that is found to provide itch relief to mice.
Salvinorin A, a hallucinogen produced by the Mexican plant Salvia divinorum, holds promise for treating itch and pain because it activates the κ-opioid receptor while avoiding the μ-opioid receptor, a sister receptor that’s been associated with opioid abuse. Chemists have tried to synthesize salvinorin A so that they could alter the structure to sidestep the compound’s psychoactive effects while preserving its analgesic properties. But salvinorin A’s scaffold has been challenging to recreate.
Now, a team of scientists at the California and Florida branches of Scripps Research Institute, as well as at the University of Southern California, report a 10-step total synthesis of 20-norsalvinorin A (ChemRxiv 2017, DOI: 10.26434/chemrxiv.5318188). The compound differs from salvinorin A by a single methyl group and binds to the κ -opioid receptor with an affinity similar to that of the natural product. When given to mice, it also provides itch relief.
Anil Dash's third law holds that "Three things never work: Voice chat, printers and projectors." But Joshua Rothman's long, fascinating, even poetic profile of the Xerox engineers who work on paper-path process improvements is such a bit of hard-science whimsy that it almost makes me forgive every hour I've spent swearing over jammed paper.
Oil of wintergreen makes for lovely glowsticks, but the secret ingredient is the solvent used to create chemiluminescence.
Lead sponge, like other metal sponges, is a phenomenon where a metal reacts with a solution to create a soft sponge-like material, as YouTuber NileRed found out by accident.
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