In his inaugural column, Munroe answers: "If I Touched the Moon, What Would It Feel Like?"
Touching lunar rocks inside a spacecraft, or in a museum, is one thing; removing a glove and exposing yourself to the vacuum of space is another. In science fiction, terrible things befall such astronauts: their blood boils away, their insides get sucked out.
But removing a glove wouldn't necessarily be instantly fatal. For the most part, human skin is tough enough to handle brief exposure to a vacuum. If you had a custom spacesuit with a seal around your forearm, you could probably remove your glove during a moonwalk without suffering permanent damage.
It definitely wouldn't be comfortable. In 1960, during a high-altitude balloon test, Air Force Col. Joe Kittinger's pressure glove sprang a leak, exposing his right hand to near-vacuum conditions for several hours. His hand swelled up and went numb, but he suffered no permanent damage.
If I Touched the Moon, What Would It Feel Like? [Randall Munroe/New York Times]