Y: The Last Man is a fantastic graphic novel/series of comix that I've been avidly following since the folks at Cambridge, MA's Million Year Picnic comic store (brilliant store!) recommended it to me last December.
It's the story of a mysterious plague that sweeps the earth, instantly killing every man (and male beast) — except one: Yorick, the son of the ranking woman Congresscritter who has become the President of the United States (oh, and his pet monkey). From this fast setup, the story turns into a cracking adventure tale that's thoughtful and exhilerating, funny and sad, mean and joyous. It's one of about five comics I really look forward to every month (others include Warren Ellis's must-read Global Crossing Frequency (thanks, PartTimeSaint) and the Legends book).
This morning, Salon has run a seven-page excerpt from the book, so you can get an idea of what I'm talking about.