Biomedical engineers prototyped a pill that integrates a syringe to inject insulin into the floor of the stomach. From Science News:
The shape is designed to guide the device to rest, cap down, on the floor of the stomach. There, it sticks a needle tip composed almost entirely of insulin a few millimeters into the mucus membrane lining the stomach. Once the insulin needle tip dissolves, the device passes through the rest of the digestive system.
Thanks to the dearth of sharp pain receptors inside the stomach, the tiny injection "is unlikely to cause any discomfort," says study coauthor Giovanni Traverso, a gastroenterologist and biomedical engineer at Brigham and Women's Hospital in Boston and MIT.
"An ingestible self-orienting system for oral delivery of macromolecules" (Science)