Crux, a sequel to Nexus - bioethical technothriller

I loved Nexus, Ramez Naam's 2012 debut novel about biohackers who produce a nano-based party drug that installs a networked computer inside your brain, and quickly turns into a war-on-drugs bioethics thriller about the free/open transhumanists and mirthless, ruthless drug enforcement agents.

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Life, death, and the people we love the most

Margaret Pabst Battin is a philosopher and right-to-die activist who firmly believes that the concepts of autonomy and mercy demand that we, as a society, allow the sick, the old, and the infirm to decide, for themselves, how and when and where they will die. In 2008, her husband, Brooke Hopkins, barely survived a bicycle accident that left him paralyzed from the neck down, on a pacemaker, and frequently sick. At The New York Times Magazine, Robin Henig tells the moving, beautiful, and sad story of a couple struggling in real life with questions that had, previously, been mostly theoretical. At the heart of it is a big, messy question: What happens if you do, sometimes, really want to die ... but the people who love you aren't ready to let go just yet? Read the rest

Why new cloned mice can help scientists treat lab animals more humanely

This week, scientists cloned a mouse from cells found in a drop of mouse blood. That's different from other cloned mice, whose creation relied on more invasive sampling from the liver, bone marrow, and lymph nodes (read: the original animal was euthanized). Cloning mice is valuable for scientific research — it's handy to have your subjects be as alike one another as possible. Now, scientists have a way to do that without having to kill the original mouse. Read the rest

Necessary Evil - a triumphant end to the Milkweed Triptych where Nazi X-Men fight English warlocks

With Necessary Evil, published today, Ian Tregillis triumphantly concludes his astonishing, brilliant, pulse-pounding debut trilogy, The Milkweed Triptych. Milkweed began in 2010 with Bitter Seeds, an alternate history WWII novel about a Nazi doctor who creates a race of twisted X-Men through a program of brutal experimentation; and of the British counter-strategy: calling up the British warlocks and paying the blood-price to the lurking elder gods who would change the very laws of physics in exchange for the blood of innocents. These elder gods, the Eidolons, hate humanity and wish to annihilate us, but we are so puny that they can only perceive us when we bleed for them. With each conjuration of the Eidolons on Britain's behalf, the warlocks bring closer the day when the Eidolons will break through and wipe humanity's stain off the universe.

Book two, The Coldest War, came out last summer -- a too-long hiatus! -- and jumped forward to the 1960s, where the struggle continued in a Europe divided among the Soviets -- who seized the Nazi technology at the end of the war and used it to breed their own supermen -- and the British, whose warlock reserves have become an everyday instrument of foreign policy. Coldest War was half James Bond, half Cthulhu, and was every bit as painstakingly researched, beautifully described, blisterlingly plotted and utterly engrossing as the first.

Now, with book three, Necessary Evil, Tregillis draws the series to a close with a time travel story that goes back to the beginning of the tale, a desperate mission to stop the use of magick and the use of the Nazi "Will to Power" from ever gaining hold, to keep the elder gods at bay. Read the rest

MacLeod's dystopian masterpiece Intrusion in paperback

Ken Macleod's amazing dystopian novel Intrusion is out in paperback today. Here's my review from last March:

Ken MacLeod's new novel Intrusion is a new kind of dystopian novel: a vision of a near future "benevolent dictatorship" run by Tony Blair-style technocrats who believe freedom isn't the right to choose, it's the right to have the government decide what you would choose, if only you knew what they knew.

Set in North London, Intrusion begins with the story of Hope, a mother who has become a pariah because she won't take "the fix," a pill that repairs known defects in a gestating fetus's genome. Hope has a "natural" toddler and is pregnant with her second, and England is in the midst of a transition from the fix being optional to being mandatory for anyone who doesn't have a "faith-based" objection. Hope's objection isn't based on religion, and she refuses to profess a belief she doesn't have, and so the net of social services and laws begins to close around her.

MacLeod widens the story from Hope, and her husband Hugh (a carpenter working with carbon-sequestering, self-forming "New Wood") who has moved to London from an independent Scotland, and whose childhood hides a series of vivid hallucinations of ancient people from the Ice Age-locked past. Soon we're learning about the bioscientists who toil to improve the world's genomes, the academics who study their work, the refuseniks who defy the system in small and large ways, and the Naxals, city-burning wreckers who would obliterate all of society.

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