Here is Atlas Obscura's list of places to explore in the Midwest. If you have an adventurous spirit and enjoy ghost towns, abandoned hospitals, and overgrown ruins of buildings, then this list might come in handy during a road trip through the Midwest.
Some of the most intriguing abandoned places on this list include a dilapidated resort in Sturgeon Bay, Wisconsin, an abandoned airport in Chicago, and spooky-looking grain silos, also located in Chicago.
If given the opportunity, I would visit any of the places mentioned on this list. Just remember to proceed with caution and be aware that not all places are open to the public.
See also: List of the largest roadside attractions in the Midwest.