Finally, researchers are again exploring the therapeutic benefits of psychedelics to treat the likes of depression, addiction, and obsessive-compulsive disorder. To provide pharmaceutical-quality compounds for clinical trials, scientists are developing new ways to produce the psychedelics. Chemical engineers at Miami University in Ohio have now genetically engineered E. coli to crank put psilocybin, the psychoactive ingredient in magic mushrooms. From Scientific American:
The modified microbes generated up to 1.16 grams of psilocybin per liter of culture medium—the highest yield to date from any engineered organism and a 10-fold increase over the next best attempt. Scaled up, the new method could produce psilocybin for potential therapeutic use.
“The number-one advantage is it's simply cheaper” than—or at least cost-competitive with—other methods, says lead study author Alexandra Adams, an undergraduate student in chemical engineering at Miami University in Ohio...
Adams and her colleagues engineered E. coli that incorporated three genes from the Psilocybe cubensis mushroom, enabling the bacteria to synthesize psilocybin from the cheap and easily obtainable precursor molecule 4-hydroxyindole, and then they optimized the process to produce the drug on a larger scale.
On Wednesday, Panama’s National Aeronaval Service seized this homemade semi-submersible vessel in territorial waters off Bocas del Toro. Authorities discovered 5 tons of drugs inside and nabbed four Colombian citizens. According to CNN, “the ministry (of public security in Panama) did not specify what type of drugs were seized in the raid, but smugglers have […]
In Florida, sheriff’s officials say a trail of pill bottles stolen from a Florida pharmacy led detectives to a home where they encountered two men who matched descriptions of robbers seen on surveillance video.
Here is another fabulous list of important records, this one organized around the theme of “most drug-addled.” As with the avant-garde list, this author’s choices are ripe for debate. The writing on the entries is also fun. RAMPANT MADNESS, cheap powder, and the whiskey river: below are the 50 most debauched, sodden, and certifiable records […]
As you shiver your way through February, you’re probably thinking about paying your heating bill. But in just a few short months, the summer sun is going to come calling — and the fear of pulling that energy bill out of your mailbox will start becoming very, very real. Air conditioning accounts for about an […]
Despite legalization in 11 states and decriminalization in 15 more, marijuana-based products are still an often tough sell with many Americans. While the psychoactive THC portion of the plant remains controversial, the medicinal impact of the non-altering component of cannibis, CBD, is widely hailed. Many portions of those claims still await medical verification, but for […]
If you remember your Norse mythology (or just watched Marvel’s Thor movies), you’re probably familiar with Heimdal, the god whose ever-watchful eye was entrusted with protecting the home of the gods in Asgard. Back on Earth, Heimdal Thor is also the name of a security package from Heimdal Security, that’s actually dedicated to much the […]