Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
"My Favorite Museum Exhibit" is a series of posts aimed at giving BoingBoing readers a chance to show off their favorite exhibits and specimens, preferably from museums that might go overlooked in the tourism pantheon. I'll be featuring posts in this series all week. Want to see them all? Check out the archive post. I'll update the full list there every morning.
Sorry. I've got a bit of THE TRIUMPH OF MAN stuck in my head. Actually, this skull belonged to a foal, says Justin Cahill, who sent in the photos. It's part of a long, natural history museum tradition of exhibiting the weird and often grotesque, preserving them as examples of how the natural way isn't always ideal. The same forces that shape evolution can also seriously screw you up. So much of what we call "normal" is based on chance.
Nobody ever actually saw this foal alive, by the way. The skull was found in the Hawkesbury River in 1841. But there have been attempts to reconstruct what the horse might have looked like during it's brief time alive. You can see that photo after the cut:
Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
National Geographic has a really interesting story on what we can learn about human biology and human culture from studying the lives of twins. (Last week, Mark blogged about some of the photos in the story.) The story explains the chance beginnings of the now-massive Minnesota Study of Twins Reared Apart; introduces you to twin girls from China who were adopted by two different Canadian families that now work to keep the girls in each other's lives; and delves into what we know and don't know about why some identical twins are different from each other in very conspicuous ways.
One example of this last bit is the story of Sam and John, identical twin brothers. Both are on the autism spectrum, but they appear to be on entirely different parts of that spectrum, with John experiencing much more severe symptoms that led the boy's parents to enroll him in a special school. Why would identical twins, raised in the same family, have such an obvious difference in the expression of characteristics that are probably mostly inherited? That's where epigenetics comes in.
A study of twins in California last year suggested that experiences in the womb and first year of life can have a major impact. John's parents wonder if that was the case with him. Born with a congenital heart defect, he underwent surgery at three and a half months, then was given powerful drugs to battle an infection. "For the first six months, John's environment was radically different than Sam's," his father says.
Shortly after Sam and John were diagnosed, their parents enrolled them in a study at the Kennedy Krieger Institute in Baltimore. Blood samples from the boys were shared with a team at nearby Johns Hopkins University looking into the connection between autism and epigenetic processes—chemical reactions tied to neither nature nor nurture but representing what researchers have called a "third component." These reactions influence how our genetic code is expressed: how each gene is strengthened or weakened, even turned on or off, to build our bones, brains, and all the other parts of our bodies.
If you think of our DNA as an immense piano keyboard and our genes as keys—each key symbolizing a segment of DNA responsible for a particular note, or trait, and all the keys combining to make us who we are—then epigenetic processes determine when and how each key can be struck, changing the tune being played.
A study at Nanjing University in China found that ingested "microRNA" (very small pieces of ribonucleic acid, or RNA) from plants were able to survive digestion and influence the function of human cells.
Food columnist Ari Levaux has a piece digging into the implications, in The Atlantic. The basic idea: if this research stands up to the rigors of scientific scrutiny, it could prove that when we eat food, we consume not just fuel and nutrients, but information that changes us on a cellular level, and influences health.
Snip:
Monsanto's website states, "There is no need for, or value in testing the safety of GM foods in humans." This viewpoint, while good for business, is built on an understanding of genetics circa 1950. It follows what's called the "Central Dogma" (PDF) of genetics, which postulates a one-way chain of command between DNA and the cells DNA governs.
The Central Dogma resembles the process of ordering a pizza. The DNA knows what kind of pizza it wants, and orders it. The RNA is the order slip, which communicates the specifics of the pizza to the cook. The finished and delivered pizza is analogous to the protein that DNA codes for.
We've known for years that the Central Dogma, though basically correct, is overly simplistic. For example: Pieces of microRNA that don't code for anything, pizza or otherwise, can travel among cells and influence their activities in many other ways. So while the DNA is ordering pizza, it's also bombarding the pizzeria with unrelated RNA messages that can cancel a cheese delivery, pay the dishwasher nine million dollars, or email the secret sauce recipe to WikiLeaks.
Monsanto's claim that human toxicology tests are unwarranted is based on the doctrine of "substantial equivalence." This term is used around the world as the basis of regulations designed to facilitate the rapid commercialization of genetically engineered foods, by sparing them from extensive safety testing.
Did natural selection help African-Americans adapt to the harsh conditions of their new lives as slaves in the Americas? A team of researchers at the Chinese Academy of Sciences in Shanghai report in the journal Genome Research that "certain disease-causing variant genes became more common in African-Americans after their ancestors reached American shores — perhaps because they conferred greater, offsetting benefits." Read more at the New York Times.
Image: The Africans of the slave bark "Wildfire"--The slave deck of the bark "Wildfire," brought into Key West on April 30, 1860. Library of Congress.
Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
Gender isn’t a simple thing. A person can be male, female, both, neither, and more—and that identity doesn’t have to have anything to do with the particular genital plumbing they were born with.
But the plumbing itself—the biological sex, rather than gender or socio-cultural sex—is also a lot more complicated (and interesting) than we often give it credit for. Don’t believe me? Then check out “DMRT1 prevents female reprogramming in the postnatal mammalian testis,” a research letter published in September in the journal Nature.
That title is full of typical peer-reviewed paper jargon, but let me break it down for you: There’s a genetic factor, present in male mammals, that is vital to making sure those mammals develop male sex characteristics. But it’s not only important during embryonic development. Oh, no. Turns out, this factor must be active in order for a male’s gonads to stay 100% male. Turn it off, even in an adult male, and the cells in his testes will start to take on more feminine characteristics.
Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
The Archon Genomics X-Prize is offering $10 million to the first research team to sequence the genomes of 100 people who are age 100 or older. The goal: Get a clear view, for the first time, of what makes centenarians different on a genetic level.
That's pretty cool. And will probably be a lost more useful than the usual answer to, "How did you live so long?," which seems to usually involve something about piss, vinegar, and ironically unhealthy lifestyle choices.
But, before the fun can start, the Prize needs to find 100 centenarians willing to donate samples of their DNA to science. That's where you come in. Do you have a friend, grandparent, or great-grandparent who'd be interested in participating in the project? If so, you should nominate them to be one of the "100 Over 100."
Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
I had a great conversation with Christina Agapakis, a science blogger at Scientific American and a scientist studying synthetic biology. In this episode of Bloggingheads.tv's Science Saturday, you'll find out what Christina learned when she traced her allergies on a phylogenetic tree, why she's currently obsessed with symbiotic bacteria, why I think adults need more opportunities for informal science education after they've left school, and how scientists and educators are trying to address clashes between science and culture.
Science Now reports on a project from David Walt (Tufts) and George Whitesides (Harvard) to come up with a steganographic text-encoding scheme that uses bacteria to encode messages and selective antibiotics to reveal them. It was conceived of in response to a DARPA challenge to devise non-electrical text-encoding, but its applications include adding text-based information to GM crops that can be read in the field (or in the market) to determine what's being grown.
The new scheme replaces the fuse with seven colonies of Escherichia coli bacteria, each given a gene for a different fluorescent protein. When, and only when, these genes are turned on do the bacteria make these proteins and light up. The colors, including yellow, green, and red, vary based on which gene is expressed. All are clearly visibly different to the naked eye. With their colorful bacterial colonies in hand, the researchers then created a code using pairs of different colored bacteria. Having seven colors gave them 49 combinations, which they used to encode the 26 different letters and 23 alphanumeric symbols such as "@" and "$." They wrote a message by simply blotting pairs of colored bacteria in rows. To "print" the message, the researchers transferred the bacteria onto a plate containing agar, a bacterial growth medium, into which they pressed a sheet of nitrocellulose "paper" that immobilizes the bacteria.
At this point, the bacteria on the nitrocellulose paper remain invisible. But the message receiver can turn on the key genes and make the colors light up by pressing the nitrocellulose paper into an agar plate containing a chemical trigger that activates expression of the fluorescent proteins. (The proteins chosen to light up are ones the bacteria don't normally use, so unless the researchers activate them, they stay quiescent.) As long as the receiver knows which colors correspond to which characters, the message is revealed. But Walt and his colleagues added one more safeguard as well. Into some bacteria they inserted genes for resistance to particular antibiotics; the idea is that only the antibiotic-resistant bacteria are carrying the real message. If the message fell into the wrong hands, the receiver would see a mix of colors once the genes were activated and be unable to read it. But if the decoder added the right antibiotic, nonresistant bacteria and their colors die away, and the message becomes clear. The first example, reported in today's issue of the Proceedings of the National Academy of Sciences reads "this is a bioencoded message from the walt lab @ tufts university 2010."
Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
James Fallon studies the brain. Then he studied his own, and found out that he has the same brain malfunctions as psychopathic serial killers. What happened next is a fascinating story about the brain, the mind, and the dueling influences of nature and nurture.
Upcoming Appearances • April 2 at Skeptics in the Pub, Boston, Mass.— 7:00 pm at Tommy Doyle's in Harvard Square. Please RSVP. •April 4 at MIT: "Shedding Light, Online", a discussion about how blogging and a dynamic audience helped shape my book, Before the Lights Go Out—4:00 pm in Maseeh Hall. Please RSVP. • April 6 at Carnegie Mellon University: More details to come
• April 9-13 at University of Colorado, Boulder: 64th Annual Conference on World Affairs • April 10 at Colorado State University, Fort Collins: "Putting the Fun Back in Infrastructure"—3:30 pm in the Rocky Mountain Innosphere. • April 19 at The Bakken Museum in Minneapolis: Book Launch Party! Come enjoy snacks, a presentation by me, and some fun with the Bakken's Leyden jar.
• April 21 at Science Museum of Minnesota, St. Paul: Earth Day Tweetup event with Will Steger and Sean Otto—events run 10:00 am to 2:00 pm.
• May 2 at University of California, Berkeley: "Putting the Fun Back in Infrastructure"—6:00 pm, location TBA.
• May 3 at the American Institute of Architects, San Francisco Chapter—Lunchtime lecture, time and location TBA.
• May 3 at Barnes and Noble, El Cerrito, Cali.—7:00 pm.
• May 30 in New York City—Panel on local and DIY energy with the New America Foundation
• June 22-25 in Aspen, Colorado: Aspen Environment Forum • July 5-8 at CONvergence in Minneapolis, Minn.—exact times and dates TBA
