Thanks to the tireless efforts of the non-profit Multidisciplinary Association for Psychedelic Studies (MAPS), the US FDA is clearing the way for ten clinics around the United States to treat PTSD patients with MDMA. It's likely that the FDA will grant full approval for the therapy in 2020, reports New Atlas. From the article:

MAPS has previously hypothesized thousands of psychedelic-assisted psychotherapy clinics will open up across the United States. In the near future these clinics may not only administer MDMA for PTSD but also psilocybin, which is currently proving promising for a variety of conditions, including major depression.

The FDA approval for Expanded Access is yet another validation of MDMA-assisted psychotherapy’s safety and efficacy following extraordinarily positive early clinical trial results. Current Phase 3 trials are set to run until 2021 and complete market approval could come as early as 2022.

Image by DMTrott - Own work. Originally published in The Drug Users Bible [ISBN: 978-0995593688]., CC BY-SA 4.0, Link Read the rest

For years a friend has been telling my diet was hurting my general demeanor. Read the rest

If you've decided to investigate treatment options for your mental health, your health insurer will cheerfully refer you to a list of hundreds of providers -- but as STAT's Jack Turban discovered, this "network" of providers is actually a "ghost network," filled with wrong numbers that ring in McDonald's restaurants and jewelers. If you happen to reach an actual mental health professional, they'll probably tell you they're not accepting new patients. Read the rest

Ketamine is a sedative first synthesized in 1962; its patents have long elapsed and it costs pennies; it has many uses and is also sold illegally for use as a recreational drug, but in recent years it has been used with remarkable efficacy as a treatment for a variety of disorders, including depression, anxiety, and chronic pain (I have lifelong chronic pain and my specialist has prescribed very low doses of it for me at bedtime). Read the rest

Earlier today, the FDA approved esketamine (brand name Spravato), a chemical twin of the dissociative psychedelic/anaesthetic ketamine (Special K), as a treatment for depression. Spravato comes in nasal spray form meant to be administered weekly or every other week depending on the severity of the patient's depression.

"There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," said the FDA's acting director of the Division of Psychiatry Products, Dr. Tiffany Farchione, in a press release. "Because of [safety] concerns, the drug will only be available through a restricted distribution system and it must be administered in a certified medical office where the health care provider can monitor the patient."

From National Public Radio:

Many doctors who have become comfortable offering ketamine for depression probably won't switch to esketamine, said Dr. Demitri Papolos, director of research for the Juvenile Bipolar Research Foundation and a clinical associate professor at Albert Einstein College of Medicine.

For the past 10 years, Papolos has been prescribing an intranasal form of ketamine for children and adolescents who have a disorder that includes symptoms of depression.

"I'm very pleased that finally the FDA has approved a form of ketamine for treatment-resistant mood disorders," Papolos said. He said the approval legitimizes the approach he and other doctors have been taking.

But he hopes that doctors who are currently using ketamine continue to do so. "It'll be a lot less expensive and a lot easier for their patients [than esketamine]," he said.

Teams of researchers are developing sesame seed-size neuro-implants that detect brain activity that signals depression and then deliver targeted electrical zaps to elevate your mood. It's very early days in the science and technology but recent studies suggest that we're on the path. Links to scientific papers below. Fortunately, the goal is to develop tools and a methodology more precise than the horrifically blunt "shock therapy" of last century. From Science News:

DARPA, a Department of Defense research agency, is funding (Massachusetts General Hospital's research on new brain stimulation methods) plus work at UCLA on targeted brain stimulation. Now in its fifth and final year, the (DARPA) project, called SUBNETS, aims to help veterans with major depression, post-traumatic stress, anxiety and other psychiatric problems. “It is extremely frustrating for patients to not know why they feel the way they do and to not be able to correct it,” Justin Sanchez, the director of DARPA’s Biological Technologies Office, said in a Nov. 30 statement. “We owe them and their families better options.”

These next-generation systems, primarily being developed at UCSF and Massachusetts General Hospital, might ultimately deliver. After detecting altered brain activity that signals a looming problem, these devices, called closed-loop stimulators, would intervene electrically with what their inventors hope is surgical precision.

In contrast to the UCSF group, Widge, who is at the University of Minnesota in Minneapolis, and his collaborators don’t focus explicitly on mood. The researchers want to avoid categorical diagnoses such as depression, which they argue can be imprecise.

I've played enough of Rockstar Games' Red Dead Redemption 2. Read the rest

I’ve always felt the urge to leave. Any place. No matter how beautiful. I want to go. When I was 18 and finished with high school, I attended my graduation ceremony, for the sake of my family, but I skipped my prom – Canada’s east coast was calling. I’d never been there before. I didn’t know what I’d find. But I was going. I made a life for myself out there, with university, work and music. I traveled up and down the coast. Cape Breton feels like a second home to me. I love the people of Maine. New Brunswick and Prince Edward Island have a place in my heart.

But eventually, I left the east. Rage, the self-entitlement that sometimes comes from surviving a shitty childhood and a need for control left me very much out of control. I destroyed a fine long-term relationship looking for who I was. I burned bridges. I did terrible things to myself and others. It was time to move on. My travels took me back home to Ontario. My father was dying. I loved and hated him for who he was and what he had done to our family. Coming home was a terror.

Uneasily settled back into my hometown, I fought to push the dogs of my recent past down into the cellar of my soul where their bark did not seem so loud. I’d gone to university for journalism, but felt too shattered by life to write. I took on a job I despised and worked it for years. Read the rest

Child psychologists have observed an increasing trend in which teens cyberbully themselves, creating anonymous accounts in which they post vicious insults and slurs that seem to be directed to them by strangers. Read the rest

Wil Wheaton has publicly discussed his anxiety and depression before; I know several people whose lives were improved by reading what he had to say. Read the rest

Being medicated is the best and the absolute worst.

I take a cocktail of anti-anxiety and anti-depressive drugs on a daily basis to help me deal with the symptoms that come with my PTSD. Most of the time, I'm grateful for them: They've helped to numb me, just enough so that I can use the techniques I've learned in therapy to help ground myself during a flashback or panic attack. Now that I'm medicated – I refused treatment for years – I'm able to maintain a healthy relationship.

The rage and detachment I've experienced these past 20 years have been tamped down far enough that I can empathize, fully, with my wife, friends and colleagues. It's hard work, sometimes! But I feel healthier than I have in years. A lot of the time, I'm even able to sleep through the night. The paranoia I deal with and the thoughts that refuse to stop tumbling around in my head give way to slumber, most evenings. It's still a frequent thing for me to wake up, sweat-drenched and alert in the dead of night, but it feels manageable. Before, it was just exhausting and sad.

But then, on occasion, a doctor decides that maybe I should be on something new; something different. This happened two days ago. I'm not digging it.

I was warned: when starting on these new pills (no, I'm not going to tell you what they are) I'd experience more anxiety for the next few weeks as the old drugs leave my system and my new pharmaceutical hotness takes hold. Read the rest

Since the earliest days of Facebook, social scientists have sent up warnings saying that the ability to maintain separate "contexts" (where you reveal different aspects of yourself to different people) was key to creating and maintaining meaningful relationships, but Mark Zuckerberg ignored this advice, insisting that everyone be identified only by their real names and present a single identity to everyone in their lives, because anything else was "two-faced." Read the rest

The prohibition on psychedelics was memorably described as "the worst case of scientific censorship since the Catholic Church banned the works of Copernicus and Galileo" by former UK Drugs Czar David Nutt, and despite the ban, there has been a consistent, determined, very promising (sometimes surprising) drumbeat of scientific papers about the use of psilocybin ("magic mushrooms") and other psychedelics in treating a range of chronic illnesses, including mental illnesses. Read the rest

A newly-published overview of self-reported ayahuasca experiences indicates that the hallucinogen can help alleviate eating disorders and reduce alcohol consumption. Now, more scientists are pushing to make it easier to study the drug legally. Read the rest

In High intelligence: A risk factor for psychological and physiological overexcitabilities, a group of academic and industry neuroscientists survey a self-selected group of 3,715 MENSA members about their mental health history and find a correlation between high IQ and clinical anxiety and depression disorders, an effect they attribute to "overexitabilities" -- "the same heightened awareness that inspires an intellectually gifted artist to create can also potentially drive that same individual to withdraw into a deep depression." Read the rest

John Brownlee lost his father to a heart attack. But it was Bruce Brownlee's depression that slowly killed him: My Father The Werewolf.

"I think about my father’s generosity a lot. My father was generous, but he was also depressed, and the nature of depression is to be selfish: to starve those who love you of the best of you, in the relentless feeding of that which can never be nourished. In that, he—the most depressed person I ever met—was also the most selfish. For my entire life, he would give me anything I asked for, as long as it was a movie or a book. But when my mother and I begged him half a dozen times to go see a doctor if he loved us, he wouldn’t lift a finger. How do generosity and selfishness co-exist like that in a person without destroying him?

I don’t know. And, of course, it did eventually destroy him. But that was my father: a lycanthrope of contrasts. Whatever he was, he was also the opposite."

I met Bruce just once and it struck me that every path to him was gated with thorns, and I thought it grew from the reading. But I'm struck more by his son's effort to break through, to finish a story that couldn't be written until the last word was said.

My Father The Werewolf [Pillpack] Read the rest