Annalee Newitz has a piece in The New York Times about the "Great Plague" of London (1665-1666)--the last outbreak of bubonic plague in England--which ended up taking the lives of almost a quarter of the city's population.
A lot of English people believed 1666 would be the year of the apocalypse. You can’t really blame them. In late spring 1665, bubonic plague began to eat away at London’s population. By fall, roughly 7,000 people were dying every week in the city. The plague lasted through most of 1666, ultimately killing about 100,000 people in London alone — and possibly as many as three-quarters of a million in England as a whole.
It felt like Armageddon. And yet it was also the beginning of a scientific renaissance in England, when doctors experimented with quarantines, sterilization and social distancing. For those of us living through these stay-at-home days of Covid-19, it’s useful to look back and see how much has changed — and how much hasn’t. Humanity has been guarding against plagues and surviving them for thousands of years, and we have managed to learn a lot along the way.
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It was most likely thanks to his [King Charles II] interest in science that government representatives and doctors quickly used social distancing methods for containing the spread of bubonic plague. Charles II issued a formal order in 1666 that ordered a halt to all public gatherings, including funerals. Already, theaters had been shut down in London, and licensing curtailed for new pubs.