A small cohort of 31 healthy young men who took 600mg of ibuprofen twice a day for six weeks developed "compensated hypogonadism" (little balls), because the ibuprofen interfered with their testosterone production and their gonads had to work overtime to compensate.
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Purdue cynically created the American opiod epidemic through a combination of bribing medical professionals to overprescribe Oxycontin, publishing junk science, and aggressively lobbying regulators at every level to turn a blind eye to the destruction of the lives of millions of patient; while the company settled a record-setting criminal case, the name of the secretive family of billionaires who run Purdue and profited from the Oxy epidemic is best known for philanthropy, not profiteering: the Sackler family.
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The PainStation is a cocktail-style Pong game that provides "sensory feedback" to players. Which is to say: pain. Physical pain.
During the game, the players place their left hands on the PEU (Pain Execution Unit) which serves as a sensor and feedback instrument. Possible feedback effects are heat impulses, an electric shock and an integrated miniature wire whip. The feedback generated is dependent on the playing process and can increase in its intensity. The respective opponent can try to alter his or her playing style to purposely change the intensity of the feedback.
Painstation is also remarkable in the degree of refinement applied to the basic Pong concept: ball speed, ricochet characteristics, bar length, etc, are all variable and under the influence of bonuses and competitive machinations. But it is the pain bonuses that matter:
Double Pain Execution Time
Quadruple Pain Execution Time
Ease the Pain!
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Shocking the bejeezus out of my lower back led me to the fastest recovery I've experienced yet from periodic bouts of debilitating back pain. For me, this inexpensive TENS unit is a winner, and was as effective as a higher-priced comparison unit I tried.
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Abuses in my youth have left me in a lot of pain. Robin McKenzie's Treat Your Own Back helped me more than any doctor.
I was desperately searching for an option other than letting doctors I do not trust operate on my spine. In response, a friend sent me a copy of this book. Spine, neck and lower back expert Robin McKenzie's Treat Your Own Back delivered enough information to let me hold off on the surgery and return to a fairly functional life.
Treat Your Own Back gives a lot of information about why the pain is happening, and what posture can do to alleviate it. Simple exercises that'll help relieve pressure on nerves, and build core strength. Common sense approaches to dealing with back pain, rather than running right for surgery.
Someday I think I'll end up under the knife. I have some good friends who have had wonderful success with it. Until I find I really need it, and I've run out of self-care options, however, I'm going to keep looking for books like this one.
Treat Your Own Back by Robin McKenzie via Amazon Read the rest
My kids haven't played with Legos in years but somehow the tiny bricks manage to crawl out of the woodwork, waiting for me like caltrops on a dark road. The pain such a tiny colorful piece of plastic can cause for a bare foot is truly indescribable. This episode of "Today I Found Out" explains why.
(via Laughing Squid)
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One of the funny things about Boing Boing is gaining access to the broken ansible in the lair's basement. Due to some as yet untheoretical relativistic cross-wiring, all it can access are random wikipedia articles from the distant future. We've been instructed in no uncertain terms never to use it, and the last editor to do so disappeared in a flash of late 1970s-era BBC special effects, presumably an extremely painful demise. This 24-bit PNG found on their laptop didn't make a lot of sense until lately; here it is for your topical interest. Read the rest
For more than a century, physicians have used music to make patients feel better before, during, and after surgery. A new scientific meta-study looks at the evidence and confirms that yes, listening to music has measurable pain-killing properties and reduces anxiety around surgery. Read the rest
In Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states, a paper in Brain by researchers led from the St Louis University Medical School, scientists document their work in switching off neural pain pathways by activating an adenosine receptor.
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One thing we can agree on: They both hurt an awful lot.
Stanley Milgram's "Obedience to Authority" experiments are infamous classics of psychology and social behavior. Back in the 1960s, Milgram set up a series of tests that showed seemingly normal people would be totally willing to torture another human being if prodded into it by an authority figure.
The basic set-up is probably familiar to you. Milgram told his test subjects that they were part of a study on learning. They were tasked with asking questions to another person, who was rigged up to an electric shock generator. When the other person got the questions wrong, the subject was supposed to zap them and then turn up the voltage. The catch was that the person getting "zapped" was actually an actor. So was the authority figure, whose job it was to tell the test subject that they must continue the experiment, no matter how much the other person pleaded for them to stop. In Milgram's original study, 65% of the subjects continued to the end of the session, eventually "administering" 450-volt shocks.
But they weren't doing it calmly. If you read Milgram's paper, you find that these people were trembling, and digging nails into their own flesh. Some of them even had seizure-like fits. Which is interesting to know when you sit down to read about Michael Shermer's recent attempt to replicate the Milgram experiments for a Dateline segment. Told they were trying out for a new reality show, the six subjects were set up to "shock" an actor, just like in Milgram's experiments. Read the rest
The biology of itching and the biology of pain are intertwined in interesting ways, writes graduate student and science blogger Aatish Bhatia. Understanding itching can help us better understand how to treat pain. I'd not seen Bhatia's blog before, but I'm really liking his style. He does a great job of breaking down the science in a clear way.
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... In the last decade, researchers have learned about receptors in the nerves under our skin that react specifically to itchy substances. When these receptors fire, they send a signal racing up our spinal cord, headed to our brain where it creates an urge to scratch. Scientists now have a basic map of the roads that an itch takes on its way to our brain. And they have even been able to block some of these roads in mice, essentially preventing them from feeling an itch.
...The picture that is emerging is a complex one, where pain and itch signals are distinct yet subtly intertwined. Of the nerve cells under our skin, some are involved only in signalling pain, and they have pain receptors. Others are responsible for signalling different types of itches, and they have both itch and pain receptors. If the same cell has both receptors, how do we distinguish itch from ouch?
... As the biology of itching becomes better understood, the benefits are making their way from the lab to the clinic. The drug morphine is a powerful painkiller, but has a common side effect of itchiness.
Someone stubs her toe. Where is the pain? In her mind ... or in the toe?
In a recent study, laypeople indicated that they thought the pain was in the toe. (Via Scientific American Mind
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A Norwegian study published in the Journal of the American Medical Association
showed that glucosamine has no effect on relieving lower back pain. Six million Americans take glucosamine supplements.
For six months, he and his colleagues gave 250 adults with chronic lower back pain and degenerative osteoarthritis either 2,500 mg daily of glucosamine sulfate or a placebo. At the six-month and one-year marks, there weren't any significant differences among patients in the two groups. Both groups did seem to be helped by the placebo effect, which is common in pain patients, in which people apparently feel better simply because they are receiving treatment.
Glucosamine No Remedy for Lower Back Pain, Says Study
A short, illustrated guide to tsubo
Quack back massager from 1930
Back pain costs $90 billion/year
Carpal Tunnel Syndrome exercises that really work
Map of prescribed psychiatric drugs in America Read the rest
A transatlantic team of scientists have discovered a secondary sensory system, independent of the well-understood nervous system, hidden in the skin. These may be at the root of inexplicable chronic pain syndromes like fibromyalgia.
"It's almost like hearing the subtle sound of a single instrument in the midst of a symphony," said senior author Frank Rice, PhD, a Neuroscience Professor at Albany Medical College (AMC), who is a leading authority on the nerve supply to the skin. "It is only when we shift focus away from the nerve endings associated with normal skin sensation that we can appreciate the sensation hidden in the background."
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The research team discovered this hidden sensory system by studying two unique patients who were diagnosed with a previously unknown abnormality by lead author David Bowsher, M.D., Honorary Senior Research Fellow at the University of Liverpool's Pain Research Institute. These patients had an extremely rare condition called congenital insensitivity to pain, meaning that they were born with very little ability to feel pain. Other rare individuals with this condition have excessively dry skin, often mutilate themselves accidentally and usually have severe mental handicaps...
The answer appeared to be in the presence of sensory nerve endings on the small blood vessels and sweat glands embedded in the skin. "For many years, my colleagues and I have detected different types of nerve endings on tiny blood vessels and sweat glands, which we assumed were simply regulating blood flow and sweating. We didn't think they could contribute to conscious sensation.