Study: THC in cannabis linked to genetic mutations in sperm

Today I learned that using cannabis can lower a fella's sperm count: those looking to partake in parenthood should take note. But that's not the only thing that cannabis can do to your swimmers. According to scientists from Duke University, using marijuana can cause genetic changes to sperm cells--something that could have far-reaching consequences for any baby a dude might father.

From The Verge:

For a study published today in the journal Epigenetics, scientists at Duke University compared the sperm of two groups of rats: those who had been given tetrahydrocannabinol (THC), the psychoactive ingredient in cannabis, and those who had not. Then they compared the sperm of 24 human men who smoked marijuana weekly versus a control group who used marijuana no more than 10 times in their life and not at all in the past half-year. In both cases — rats and humans — marijuana changed how genes work in sperm cells.

In both rats and humans, the cannabis affected many different genes involved in two different pathways. (Think of pathways as another set of instructions, this time for regulating various bodily functions.) One is important for organs to reach full size, and one plays a role in cancer and suppressing tumors.

Before anyone loses their shit, this doesn't mean that any kid you conceive while THC is coursing through your body will be more likely to get cancer. A lot more research needs to be conducted before any firm conclusions can be drawn. As The Verge points out, there were no laboratory controls on how much THC was consumed by the test subjects. Read the rest

The difference between CBD and THC in cannabis, explained

With weed becoming welcome in more locales every week, a lot of folks may be considering partaking for the first time. If you count yourself among them, chances are that you already know what cannabis can do for you. However, it might also do you some good to understand exactly how it does what it does. This short video will see you sorted out. Read the rest

This mossy plant may be 'more medically effective than cannabis'

Something interesting from the world of science: Liverwort contains a psychoactive substance ("perrottetinene" or "PET") that has similar molecular structures to THC. Researchers think might be superior to THC for dampening pain signals and reducing inflammation. It just doesn't produce the same kind of high.

ScienceDaily:

Until now, it was thought that cannabis was the only plant that produces THC. However, as early as 1994, Japanese phytochemist Yoshinori Asakawa had discovered a substance in the liverwort plant Radula perrottetii which was related to THC and had named this natural substance "perrottetinene." In this natural product, the individual atoms are linked together in a manner similar to that of THC, however they differ in their three-dimensional structure and further exhibit an additional benzyl group.

A few year ago, Jürg Gertsch from the Institute of Biochemistry and Molecular Medicine at the University of Bern discovered that liverworts were being advertised as so-called "legal highs" on the internet. At the time, nothing was known about the pharmacological effects of this substance. Together with chemists from Erick Carreira's team from the Department of Chemistry at the ETH Zürich, Gertsch's research team in Bern biochemically and pharmacologically compared THC and perrottetinene.

Using animal models, they were able to demonstrate that perrottetinene reaches the brain very easily and that, once there, it specifically activates cannabinoid receptors. It even demonstrates a stronger anti-inflammatory effect in the brain than THC, something which makes perrottetinene particularly interesting when you consider its potential medical application "It's astonishing that only two species of plants, separated by 300 million years of evolution, produce psychoactive cannabinoids," says Gertsch.

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The DEATH STAR, an armored weed grinder with enough power to grind weed

I could not resist a $9 Death Star weed grinder.

It looks like the Death Star and it grinds weed! Mission accomplished. I am not sure I will use it very often, but this grinder will sit next to the headpiece for the Staff of Ra in my living room. Its a cool knickknack for $9.

The 'heavy feeling' zinc alloy feels heavy. You have the choice of leaving a screen in and having the weed all sit in the grinder teeth, and kief falling in a holding cell -- OR you can remove the screen and have the weed all just fall together! Not a lot to this baby.

This item appears to be the same as more expensive variants of the Death Star grinder, down to the packaging. This version does not come with the cleaning tools that I doubt you'll really want.

Formax420 Death Star Grinder Star War Round Grinder 3 Pieces Spice Mill 1.9 inch via Amazon Read the rest