Researchers identified a phytocannabinoid in Cannabis sativa that they say could be 30 times more powerful than THC, at least in their lab results. The scientists from Italy's University of Modena and Reggio Emilia and their colleagues found that in their in vitro tests, tetrahydrocannabiphorol (THCP) showed an attraction to the nervous system's cannabinoid (CB1) receptor that's more than thirty times higher than good ol' THC. From CNN:

CBD has mostly been the focus of studies on the health benefits of cannabis, but because THCP appears to show stronger binding abilities and potency, the authors think there is potential for health benefits.

The findings could enable the production of cannabis extracts for targeted physical effects; more testing with the study's methods could further the discovery and identification of new compounds, the authors said.

"There are other minor cannabinoids and traces in the plant that can be hard to study, but by isolation we can continue to assess the effects they might offer," (said Jane Ishmael, associate professor in Oregon State University's College of Pharmacy, who was not involved in the research.

"Historically, many of our medicines have been derived by or inspired by natural products. By having new compounds that bind with very high affinity, that will give scientists a new probe into biological sciences."

Read the scientific paper: "A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol" (Nature Scientific Reports)

image: Thayne Tuason (CC BY-SA 4.0 Read the rest

Not so dank, dudes. Read the rest

Talk about being irresponsible, Sunset posted an article that suggests serving a "THC-laced turkey gravy" as a way to avoid, or smooth over, uncomfortable conversations with your family at the Thanksgiving table. Read the rest

Suspension of disbelief is real, yo.

WPXI:

“I’m thinking this lady must have vaped this THC oil and got a high level in her system and (it) made her stop breathing, like a respiratory failure,” Montegut, who has served as coroner since 1988, told The Advocate.

However, experts are doubtful. There are no reports of teens or adults dying solely from marijuana, according to the National Institute on Drug Abuse.

“We know from really good survey data that Americans use cannabis products billions of times a year, collectively. Not millions of times, but billions of times a year,” Keith Humphreys, a former senior policy adviser at the White House Office of National Drug Control Policy, told The Advocate. “So, that means that if the risk of death was one in a million, we would have a couple thousand cannabis overdose deaths a year. Let’s assume (that the woman died from THC) is a fact. What do you conclude from that? It doesn’t justify really anything from a policy viewpoint. It’s just so incredibly unlikely.”

Montegut stands by his report.

"I'm 100 percent sure of the readings we've found,” he told WWLT. “I definitely did some research before I came to the conclusion that this was the cause of death."

CBD-infused snacks could soon join the product line that includes Chips Ahoy cookies, Cadbury chocolate, and Nutter Butter cookies. Read the rest

Science will open the floodgates on cheap, reliable high-volume production of THC and CBD. Yeast's rapid growth and ease of culturing will likely enable new stronger-better-faster variants of both.

UC Berkeley College of Chemistry:

UC Berkeley synthetic biologists have engineered brewer’s yeast to produce marijuana’s main ingredients—mind-altering THC and non-psychoactive CBD—as well as novel cannabinoids not found in the plant itself.

Feeding only on sugar, the yeast are an easy and cheap way to produce pure cannabinoids that today are costly to extract from the buds of the marijuana plant, Cannabis sativa.

“For the consumer, the benefits are high-quality, low-cost CBD and THC: you get exactly what you want from yeast,” said Jay Keasling, a UC Berkeley professor of chemical and biomolecular engineering and of bioengineering and a faculty scientist at Lawrence Berkeley National Laboratory. “It is a safer, more environmentally friendly way to produce cannabinoids.”

Today I learned that using cannabis can lower a fella's sperm count: those looking to partake in parenthood should take note. But that's not the only thing that cannabis can do to your swimmers. According to scientists from Duke University, using marijuana can cause genetic changes to sperm cells--something that could have far-reaching consequences for any baby a dude might father.

From The Verge:

For a study published today in the journal Epigenetics, scientists at Duke University compared the sperm of two groups of rats: those who had been given tetrahydrocannabinol (THC), the psychoactive ingredient in cannabis, and those who had not. Then they compared the sperm of 24 human men who smoked marijuana weekly versus a control group who used marijuana no more than 10 times in their life and not at all in the past half-year. In both cases — rats and humans — marijuana changed how genes work in sperm cells.

In both rats and humans, the cannabis affected many different genes involved in two different pathways. (Think of pathways as another set of instructions, this time for regulating various bodily functions.) One is important for organs to reach full size, and one plays a role in cancer and suppressing tumors.

Before anyone loses their shit, this doesn't mean that any kid you conceive while THC is coursing through your body will be more likely to get cancer. A lot more research needs to be conducted before any firm conclusions can be drawn. As The Verge points out, there were no laboratory controls on how much THC was consumed by the test subjects. Read the rest

With weed becoming welcome in more locales every week, a lot of folks may be considering partaking for the first time. If you count yourself among them, chances are that you already know what cannabis can do for you. However, it might also do you some good to understand exactly how it does what it does. This short video will see you sorted out. Read the rest

Something interesting from the world of science: Liverwort contains a psychoactive substance ("perrottetinene" or "PET") that has similar molecular structures to THC. Researchers think might be superior to THC for dampening pain signals and reducing inflammation. It just doesn't produce the same kind of high.

ScienceDaily:

Until now, it was thought that cannabis was the only plant that produces THC. However, as early as 1994, Japanese phytochemist Yoshinori Asakawa had discovered a substance in the liverwort plant Radula perrottetii which was related to THC and had named this natural substance "perrottetinene." In this natural product, the individual atoms are linked together in a manner similar to that of THC, however they differ in their three-dimensional structure and further exhibit an additional benzyl group.

A few year ago, Jürg Gertsch from the Institute of Biochemistry and Molecular Medicine at the University of Bern discovered that liverworts were being advertised as so-called "legal highs" on the internet. At the time, nothing was known about the pharmacological effects of this substance. Together with chemists from Erick Carreira's team from the Department of Chemistry at the ETH Zürich, Gertsch's research team in Bern biochemically and pharmacologically compared THC and perrottetinene.

Using animal models, they were able to demonstrate that perrottetinene reaches the brain very easily and that, once there, it specifically activates cannabinoid receptors. It even demonstrates a stronger anti-inflammatory effect in the brain than THC, something which makes perrottetinene particularly interesting when you consider its potential medical application "It's astonishing that only two species of plants, separated by 300 million years of evolution, produce psychoactive cannabinoids," says Gertsch.

I could not resist a $9 Death Star weed grinder.

It looks like the Death Star and it grinds weed! Mission accomplished. I am not sure I will use it very often, but this grinder will sit next to the headpiece for the Staff of Ra in my living room. Its a cool knickknack for $9.

The 'heavy feeling' zinc alloy feels heavy. You have the choice of leaving a screen in and having the weed all sit in the grinder teeth, and kief falling in a holding cell -- OR you can remove the screen and have the weed all just fall together! Not a lot to this baby.

This item appears to be the same as more expensive variants of the Death Star grinder, down to the packaging. This version does not come with the cleaning tools that I doubt you'll really want.

Formax420 Death Star Grinder Star War Round Grinder 3 Pieces Spice Mill 1.9 inch via Amazon Read the rest